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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 1994 Volume 4 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 1994 Volume 4 Issue 1

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Article

THE ROLE OF HISTOPATHOLOGIC SUBTYPING IN PREDICTING NEUROLOGIC COMPLICATIONS IN SMALL-CELL LUNG-CANCER

  • Authors:
    • AGM VANOOSTERHOUT
    • FBJM THUNNISSEN
    • A VOLOVICS
    • M VANDENPOL
    • GPM TENVELDE
    • A TWIJNSTRA

  • View Affiliations / Copyright

    Affiliations: UNIV LIMBURG HOSP,DEPT NEUROL,POB 5800,6202 AZ MAASTRICHT,NETHERLANDS. UNIV LIMBURG HOSP,DEPT PULMONOL,6202 AZ MAASTRICHT,NETHERLANDS. UNIV LIMBURG HOSP,DEPT PATHOL,6202 AZ MAASTRICHT,NETHERLANDS. UNIV LIMBURG HOSP,DEPT MED STAT,6202 AZ MAASTRICHT,NETHERLANDS.
  • Pages: 201-205
    |
    Published online on: January 1, 1994
       https://doi.org/10.3892/ijo.4.1.201
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Abstract

We examined the significance of histologic subtyping of small cell lung cancer (SCLC) as a prognostic factor for neurologic complications and in particular central nervous system (CNS) metastases. Pretreatment material of 239 consecutive patients with SCLC was retrospectively reexamined according to the histologic subclassification of the Pathology Panel of the International Association for the Study of Lung Cancer. Besides the classic small cell type (n=178), this subclassification distinguishes two variant cell types: mixed (n=31) and combined (n=1), which were treated as one group in the further statistical analysis. Twenty nine cases were not classified, for the following reasons: autopsy material only (n=14), slides missing (n=7), and initial SCLC diagnosis changed (n=8). The results showed that neurologic complications registered in a prospective neurologic follow-up were common in both subtypes and predominantly metastatic in nature. The data did not reveal any significant difference between histologic subtypes with regard to CNS metastases and brain metastatic-free survival. Paraneoplastic syndromes tended to occur more frequently in patients with classic small cell type. However, this relationship needs further study. It was concluded that no prognostic relevance exists for histologic subtyping with respect to neurologic complications.

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Copy and paste a formatted citation
Spandidos Publications style
VANOOSTERHOUT A, THUNNISSEN F, VOLOVICS A, VANDENPOL M, TENVELDE G and TWIJNSTRA A: THE ROLE OF HISTOPATHOLOGIC SUBTYPING IN PREDICTING NEUROLOGIC COMPLICATIONS IN SMALL-CELL LUNG-CANCER. Int J Oncol 4: 201-205, 1994.
APA
VANOOSTERHOUT, A., THUNNISSEN, F., VOLOVICS, A., VANDENPOL, M., TENVELDE, G., & TWIJNSTRA, A. (1994). THE ROLE OF HISTOPATHOLOGIC SUBTYPING IN PREDICTING NEUROLOGIC COMPLICATIONS IN SMALL-CELL LUNG-CANCER. International Journal of Oncology, 4, 201-205. https://doi.org/10.3892/ijo.4.1.201
MLA
VANOOSTERHOUT, A., THUNNISSEN, F., VOLOVICS, A., VANDENPOL, M., TENVELDE, G., TWIJNSTRA, A."THE ROLE OF HISTOPATHOLOGIC SUBTYPING IN PREDICTING NEUROLOGIC COMPLICATIONS IN SMALL-CELL LUNG-CANCER". International Journal of Oncology 4.1 (1994): 201-205.
Chicago
VANOOSTERHOUT, A., THUNNISSEN, F., VOLOVICS, A., VANDENPOL, M., TENVELDE, G., TWIJNSTRA, A."THE ROLE OF HISTOPATHOLOGIC SUBTYPING IN PREDICTING NEUROLOGIC COMPLICATIONS IN SMALL-CELL LUNG-CANCER". International Journal of Oncology 4, no. 1 (1994): 201-205. https://doi.org/10.3892/ijo.4.1.201
Copy and paste a formatted citation
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Spandidos Publications style
VANOOSTERHOUT A, THUNNISSEN F, VOLOVICS A, VANDENPOL M, TENVELDE G and TWIJNSTRA A: THE ROLE OF HISTOPATHOLOGIC SUBTYPING IN PREDICTING NEUROLOGIC COMPLICATIONS IN SMALL-CELL LUNG-CANCER. Int J Oncol 4: 201-205, 1994.
APA
VANOOSTERHOUT, A., THUNNISSEN, F., VOLOVICS, A., VANDENPOL, M., TENVELDE, G., & TWIJNSTRA, A. (1994). THE ROLE OF HISTOPATHOLOGIC SUBTYPING IN PREDICTING NEUROLOGIC COMPLICATIONS IN SMALL-CELL LUNG-CANCER. International Journal of Oncology, 4, 201-205. https://doi.org/10.3892/ijo.4.1.201
MLA
VANOOSTERHOUT, A., THUNNISSEN, F., VOLOVICS, A., VANDENPOL, M., TENVELDE, G., TWIJNSTRA, A."THE ROLE OF HISTOPATHOLOGIC SUBTYPING IN PREDICTING NEUROLOGIC COMPLICATIONS IN SMALL-CELL LUNG-CANCER". International Journal of Oncology 4.1 (1994): 201-205.
Chicago
VANOOSTERHOUT, A., THUNNISSEN, F., VOLOVICS, A., VANDENPOL, M., TENVELDE, G., TWIJNSTRA, A."THE ROLE OF HISTOPATHOLOGIC SUBTYPING IN PREDICTING NEUROLOGIC COMPLICATIONS IN SMALL-CELL LUNG-CANCER". International Journal of Oncology 4, no. 1 (1994): 201-205. https://doi.org/10.3892/ijo.4.1.201
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