THE ROLE OF NATURAL-KILLER-CELLS IN THE PATHOGENESIS OF EPSTEIN-BARR VIRUS-ASSOCIATED BURKITT-LYMPHOMA IN A SCID MOUSE MODEL
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- Published online on: January 1, 1994 https://doi.org/10.3892/ijo.4.1.225
- Pages: 225-229
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Abstract
Epstein-Barr virus (EBV) is associated with both benign and malignant lymphoproliferative processes. Recently, mice with severe combined immunodeficiency (SCID) have been described that develop EBV-induced lymphomas when inoculated with peripheral blood lymphocytes from EBV-seropositive individuals. To investigate the pathogenesis of EBV-associated Burkitt lymphomas, we intraperitoneally inoculated SCID mice with cells from EBV-infected Burkitt lymphoma (BL) cell lines. In general, cells from BL lines developed into BL-like tumors. Certain BL cell lines, however, were not particularly tumorigenic in these animals. Antibody capable of depleting mice of natural killer cells (anti-asialo GM1) favored the development of these Burkitt lymphomas. The pathogenetic implications of this animal model for human disease is discussed.