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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 1994 Volume 4 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March 1994 Volume 4 Issue 3

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Article

ORAL VERSUS INTRAVENOUS CMF IN METASTATIC BREAST-CANCER - A RANDOMIZED STUDY

  • Authors:
    • M BRANDI
    • A DEMITRIO
    • P DITONNO
    • A CATINO
    • V LORUSSO
    • M DELENA

  • View Affiliations / Copyright

    Affiliations: ONCOL INST,DIV MED ONCOL,VIA AMENDOLA 209,I-70126 BARI,ITALY.
  • Pages: 559-565
    |
    Published online on: March 1, 1994
       https://doi.org/10.3892/ijo.4.3.559
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Abstract

Sixty-eight patients with previously untreated metastatic breast cancer were randomly assigned to receive either 'classical CMF' (orally administered cyclophosphamide) or new intravenous administration of all drugs every 3 weeks. Overall response rates of 44.5% (95% CI: 28-62%) and 39% (95% CI:24-54%) were observed with classical and new CMF, respectively. The time to progression and overall survival were also similar: hematologic toxicity was mild in both groups, but the tolerance and patient compliance was generally better for the new CMF. The patients treated with classical CMF received a significantly higher drug intensity; dose intensity, however, had no impact on clinical results. In conclusion, our data suggest that the new CMF schedule has comparable activity to classical CMF but better patient compliance. A brief review of recent clinical studies regarding dose-effect relationships in breast cancer is included.

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Copy and paste a formatted citation
Spandidos Publications style
BRANDI M, DEMITRIO A, DITONNO P, CATINO A, LORUSSO V and DELENA M: ORAL VERSUS INTRAVENOUS CMF IN METASTATIC BREAST-CANCER - A RANDOMIZED STUDY. Int J Oncol 4: 559-565, 1994.
APA
BRANDI, M., DEMITRIO, A., DITONNO, P., CATINO, A., LORUSSO, V., & DELENA, M. (1994). ORAL VERSUS INTRAVENOUS CMF IN METASTATIC BREAST-CANCER - A RANDOMIZED STUDY. International Journal of Oncology, 4, 559-565. https://doi.org/10.3892/ijo.4.3.559
MLA
BRANDI, M., DEMITRIO, A., DITONNO, P., CATINO, A., LORUSSO, V., DELENA, M."ORAL VERSUS INTRAVENOUS CMF IN METASTATIC BREAST-CANCER - A RANDOMIZED STUDY". International Journal of Oncology 4.3 (1994): 559-565.
Chicago
BRANDI, M., DEMITRIO, A., DITONNO, P., CATINO, A., LORUSSO, V., DELENA, M."ORAL VERSUS INTRAVENOUS CMF IN METASTATIC BREAST-CANCER - A RANDOMIZED STUDY". International Journal of Oncology 4, no. 3 (1994): 559-565. https://doi.org/10.3892/ijo.4.3.559
Copy and paste a formatted citation
x
Spandidos Publications style
BRANDI M, DEMITRIO A, DITONNO P, CATINO A, LORUSSO V and DELENA M: ORAL VERSUS INTRAVENOUS CMF IN METASTATIC BREAST-CANCER - A RANDOMIZED STUDY. Int J Oncol 4: 559-565, 1994.
APA
BRANDI, M., DEMITRIO, A., DITONNO, P., CATINO, A., LORUSSO, V., & DELENA, M. (1994). ORAL VERSUS INTRAVENOUS CMF IN METASTATIC BREAST-CANCER - A RANDOMIZED STUDY. International Journal of Oncology, 4, 559-565. https://doi.org/10.3892/ijo.4.3.559
MLA
BRANDI, M., DEMITRIO, A., DITONNO, P., CATINO, A., LORUSSO, V., DELENA, M."ORAL VERSUS INTRAVENOUS CMF IN METASTATIC BREAST-CANCER - A RANDOMIZED STUDY". International Journal of Oncology 4.3 (1994): 559-565.
Chicago
BRANDI, M., DEMITRIO, A., DITONNO, P., CATINO, A., LORUSSO, V., DELENA, M."ORAL VERSUS INTRAVENOUS CMF IN METASTATIC BREAST-CANCER - A RANDOMIZED STUDY". International Journal of Oncology 4, no. 3 (1994): 559-565. https://doi.org/10.3892/ijo.4.3.559
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