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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 1994 Volume 4 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 1994 Volume 4 Issue 3

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Article

MECHANISMS OF DEREGULATED HER2/NEU EXPRESSION IN BREAST-CANCER CELL-LINES

  • Authors:
    • SJ MILLER
    • TC SUEN
    • TB SEXTON
    • MC HUNG

  • View Affiliations / Copyright

    Affiliations: UNIV TEXAS,MD ANDERSON CANC CTR,DEPT TUMOR BIOL,BOX 79,1515 HOLCOMBE BLVD,HOUSTON,TX 77030.
  • Pages: 599-608
    |
    Published online on: March 1, 1994
       https://doi.org/10.3892/ijo.4.3.599
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Abstract

Mechanisms that result in HER2/neu over-expression in breast cancer were examined by studying breast cancer cell lines that express much higher levels of HER2/neu mRNA than normal breast tissue while maintaining a near normal HER2/neu gene copy number. Nuclear run-on experiments indicate that the breast cancer cell lines MDA-MB453, BT483 and BT474 have an increased HER2/neu gene transcription rate. By using HER2/neu promoter-CAT constructs, we show that the enhanced HER2/neu transcription rate in MDA-MB453 is due to activation of the gene in trans. We have localized a 13-bp element on the gene promoter that is required for the increased transcription rate and have demonstrated sequence specific interaction of this fragment with a nuclear protein complex. We have also shown that in BT474 cells, transcriptional upregulation is mainly due to gene amplification and does not fully account for the levels of HER2/neu mRNA, demonstrating that deregulation of HER2/neu expression at the post-transcriptional level significantly contributes to HER2/neu overexpression in BT474 cells. Our results suggest that multiple activations of the HER2/neu gene are involved in HER2/neu over-expression in breast cancer lines and that multiple mechanisms may function simultaneously within a single cell line.

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Copy and paste a formatted citation
Spandidos Publications style
MILLER S, SUEN T, SEXTON T and HUNG M: MECHANISMS OF DEREGULATED HER2/NEU EXPRESSION IN BREAST-CANCER CELL-LINES. Int J Oncol 4: 599-608, 1994.
APA
MILLER, S., SUEN, T., SEXTON, T., & HUNG, M. (1994). MECHANISMS OF DEREGULATED HER2/NEU EXPRESSION IN BREAST-CANCER CELL-LINES. International Journal of Oncology, 4, 599-608. https://doi.org/10.3892/ijo.4.3.599
MLA
MILLER, S., SUEN, T., SEXTON, T., HUNG, M."MECHANISMS OF DEREGULATED HER2/NEU EXPRESSION IN BREAST-CANCER CELL-LINES". International Journal of Oncology 4.3 (1994): 599-608.
Chicago
MILLER, S., SUEN, T., SEXTON, T., HUNG, M."MECHANISMS OF DEREGULATED HER2/NEU EXPRESSION IN BREAST-CANCER CELL-LINES". International Journal of Oncology 4, no. 3 (1994): 599-608. https://doi.org/10.3892/ijo.4.3.599
Copy and paste a formatted citation
x
Spandidos Publications style
MILLER S, SUEN T, SEXTON T and HUNG M: MECHANISMS OF DEREGULATED HER2/NEU EXPRESSION IN BREAST-CANCER CELL-LINES. Int J Oncol 4: 599-608, 1994.
APA
MILLER, S., SUEN, T., SEXTON, T., & HUNG, M. (1994). MECHANISMS OF DEREGULATED HER2/NEU EXPRESSION IN BREAST-CANCER CELL-LINES. International Journal of Oncology, 4, 599-608. https://doi.org/10.3892/ijo.4.3.599
MLA
MILLER, S., SUEN, T., SEXTON, T., HUNG, M."MECHANISMS OF DEREGULATED HER2/NEU EXPRESSION IN BREAST-CANCER CELL-LINES". International Journal of Oncology 4.3 (1994): 599-608.
Chicago
MILLER, S., SUEN, T., SEXTON, T., HUNG, M."MECHANISMS OF DEREGULATED HER2/NEU EXPRESSION IN BREAST-CANCER CELL-LINES". International Journal of Oncology 4, no. 3 (1994): 599-608. https://doi.org/10.3892/ijo.4.3.599
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