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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 1994 Volume 4 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March 1994 Volume 4 Issue 3

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Article

MOLECULAR ASPECTS OF HEPATOCARCINOGENESIS AND THEIR CLINICAL IMPLICATIONS - REVIEW

  • Authors:
    • N NISHIDA
    • Y FUKUDA
    • K ISHIZAKI

  • View Affiliations / Copyright

    Affiliations: KYOTO UNIV,CTR RADIAT BIOL,YOSHIDA KONOECHO,SAKYO KU,KYOTO 606,JAPAN. KYOTO UNIV,FAC MED,DEPT INTERNAL MED 2,SAKYO KU,KYOTO 606,JAPAN.
  • Pages: 615-622
    |
    Published online on: March 1, 1994
       https://doi.org/10.3892/ijo.4.3.615
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Abstract

The formation and development of cancer is associated with various genetic abnormalities. Recent progress in the study of genetic changes in hepatocellular carcinoma (HCC) have clarified the aberrations of oncogenes and tumor suppressor genes, as well as the role of the hepatitis virus in hepatocarcinogenesis. Overexpression of the c-myc gene, inactivation of the p53 and RB genes, and the loss of heterozygosity (LOH) of some chromosomes where tumor suppressor genes may be located have been reported in association with the progression of HCC. However, genetic abnormalities of HCC at the early stages have yet to be elucidated. On the other hand, the association between HCC and chronic infection with the hepatitis virus also shows the relevance of the oncogenic potential of the hepatitis virus to HCC formation. Some regions of HBV genome, especially the HBV X gene, stimulate the various cellular activities related to tumor promotion and contribute to hepatocarcinogenesis. The knowledge of genetic abnormalities is helpful in the elucidation of pathogenesis and probably in the diagnosis, prognosis and therapy of HCC. Further studies of these genetic changes will apparently promote molecular diagnosis and gene therapy in HCC.

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Copy and paste a formatted citation
Spandidos Publications style
NISHIDA N, FUKUDA Y and ISHIZAKI K: MOLECULAR ASPECTS OF HEPATOCARCINOGENESIS AND THEIR CLINICAL IMPLICATIONS - REVIEW. Int J Oncol 4: 615-622, 1994.
APA
NISHIDA, N., FUKUDA, Y., & ISHIZAKI, K. (1994). MOLECULAR ASPECTS OF HEPATOCARCINOGENESIS AND THEIR CLINICAL IMPLICATIONS - REVIEW. International Journal of Oncology, 4, 615-622. https://doi.org/10.3892/ijo.4.3.615
MLA
NISHIDA, N., FUKUDA, Y., ISHIZAKI, K."MOLECULAR ASPECTS OF HEPATOCARCINOGENESIS AND THEIR CLINICAL IMPLICATIONS - REVIEW". International Journal of Oncology 4.3 (1994): 615-622.
Chicago
NISHIDA, N., FUKUDA, Y., ISHIZAKI, K."MOLECULAR ASPECTS OF HEPATOCARCINOGENESIS AND THEIR CLINICAL IMPLICATIONS - REVIEW". International Journal of Oncology 4, no. 3 (1994): 615-622. https://doi.org/10.3892/ijo.4.3.615
Copy and paste a formatted citation
x
Spandidos Publications style
NISHIDA N, FUKUDA Y and ISHIZAKI K: MOLECULAR ASPECTS OF HEPATOCARCINOGENESIS AND THEIR CLINICAL IMPLICATIONS - REVIEW. Int J Oncol 4: 615-622, 1994.
APA
NISHIDA, N., FUKUDA, Y., & ISHIZAKI, K. (1994). MOLECULAR ASPECTS OF HEPATOCARCINOGENESIS AND THEIR CLINICAL IMPLICATIONS - REVIEW. International Journal of Oncology, 4, 615-622. https://doi.org/10.3892/ijo.4.3.615
MLA
NISHIDA, N., FUKUDA, Y., ISHIZAKI, K."MOLECULAR ASPECTS OF HEPATOCARCINOGENESIS AND THEIR CLINICAL IMPLICATIONS - REVIEW". International Journal of Oncology 4.3 (1994): 615-622.
Chicago
NISHIDA, N., FUKUDA, Y., ISHIZAKI, K."MOLECULAR ASPECTS OF HEPATOCARCINOGENESIS AND THEIR CLINICAL IMPLICATIONS - REVIEW". International Journal of Oncology 4, no. 3 (1994): 615-622. https://doi.org/10.3892/ijo.4.3.615
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