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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 1994 Volume 4 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 1994 Volume 4 Issue 4

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Article

ALTERATIONS IN INTEGRIN AND BASEMENT-MEMBRANE PROTEIN EXPRESSION BY MALIGNANT BREAST CELLS

  • Authors:
    • LM BERGSTRAESSER
    • SA WEITZMAN

  • View Affiliations / Copyright

    Affiliations: NORTHWESTERN UNIV,CTR CANC,SCH MED,DEPT MED,DIV HEMATOL ONCOL,CHICAGO,IL 60611.
  • Pages: 915-930
    |
    Published online on: April 1, 1994
       https://doi.org/10.3892/ijo.4.4.915
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Abstract

We investigated expression of eight integrin subunits and four basement membrane proteins by normal and malignant human mammary epithelial cells (HMEC) in culture and in tissue sections. Normal HMEC expressed the same six integrin subunits in culture and in vivo. Expression of some of these was altered in vivo in breast carcinomas: alpha1 was not observed and beta4 was missing from some cells-changes that were not genetic, as malignant cells in primary culture could express these subunits. Nor was expression of these subunits related to expression of their basement membrane protein ligands. Other integrin subunits were reduced in culture, and expression of basement membrane proteins differed between normal and malignant cells and cells in vivo and in culture. Our results suggest that breast carcinoma cells have altered regulation of expression of adhesion receptors and their ligands, and these alterations can be manipulated in culture for further study.

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Copy and paste a formatted citation
Spandidos Publications style
BERGSTRAESSER L and WEITZMAN S: ALTERATIONS IN INTEGRIN AND BASEMENT-MEMBRANE PROTEIN EXPRESSION BY MALIGNANT BREAST CELLS. Int J Oncol 4: 915-930, 1994.
APA
BERGSTRAESSER, L., & WEITZMAN, S. (1994). ALTERATIONS IN INTEGRIN AND BASEMENT-MEMBRANE PROTEIN EXPRESSION BY MALIGNANT BREAST CELLS. International Journal of Oncology, 4, 915-930. https://doi.org/10.3892/ijo.4.4.915
MLA
BERGSTRAESSER, L., WEITZMAN, S."ALTERATIONS IN INTEGRIN AND BASEMENT-MEMBRANE PROTEIN EXPRESSION BY MALIGNANT BREAST CELLS". International Journal of Oncology 4.4 (1994): 915-930.
Chicago
BERGSTRAESSER, L., WEITZMAN, S."ALTERATIONS IN INTEGRIN AND BASEMENT-MEMBRANE PROTEIN EXPRESSION BY MALIGNANT BREAST CELLS". International Journal of Oncology 4, no. 4 (1994): 915-930. https://doi.org/10.3892/ijo.4.4.915
Copy and paste a formatted citation
x
Spandidos Publications style
BERGSTRAESSER L and WEITZMAN S: ALTERATIONS IN INTEGRIN AND BASEMENT-MEMBRANE PROTEIN EXPRESSION BY MALIGNANT BREAST CELLS. Int J Oncol 4: 915-930, 1994.
APA
BERGSTRAESSER, L., & WEITZMAN, S. (1994). ALTERATIONS IN INTEGRIN AND BASEMENT-MEMBRANE PROTEIN EXPRESSION BY MALIGNANT BREAST CELLS. International Journal of Oncology, 4, 915-930. https://doi.org/10.3892/ijo.4.4.915
MLA
BERGSTRAESSER, L., WEITZMAN, S."ALTERATIONS IN INTEGRIN AND BASEMENT-MEMBRANE PROTEIN EXPRESSION BY MALIGNANT BREAST CELLS". International Journal of Oncology 4.4 (1994): 915-930.
Chicago
BERGSTRAESSER, L., WEITZMAN, S."ALTERATIONS IN INTEGRIN AND BASEMENT-MEMBRANE PROTEIN EXPRESSION BY MALIGNANT BREAST CELLS". International Journal of Oncology 4, no. 4 (1994): 915-930. https://doi.org/10.3892/ijo.4.4.915
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