Proteases have been widely implicated in tumor invasion and metastases. Likewise, receptors for MMP-2, alpha(2)M, UA and tPA may play a critical regulatory role in modulation protease activity and invasion. These studies have been largely based on in vitro assays with various tumor lines. More recently in situ studies have indicated that metalloproteinases (e.g. MMP-2, UA, tPA) may serve as useful diagnostic or prognostic indicators of tumor progression and metastatic potential. The development of in vitro diagnostic procedures utilizing primary epithelial prostate cultures is considered. Also the potential role of growth factors (PDGF, EGF, TGFB) in the regulation of metalloprotease production is considered. Finally, approaches to drug design and development of chemotherapy regimens are considered which selectively block invasive behavior of metastatically aggressive tumors.

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