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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 1994 Volume 4 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 1994 Volume 4 Issue 6

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Article

LOCALIZATION OF EXPRESSION OF FIBROBLAST GROWTH-FACTORS AND THEIR RECEPTORS IN PANCREATIC ADENOCARCINOMA BY IN-SITU HYBRIDIZATION

  • Authors:
    • HY LEUNG
    • CM HUGHES
    • G KLOPPEL
    • RCN WILLIAMSON
    • NR LEMOINE

  • View Affiliations / Copyright

    Affiliations: HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,ICRF ONCOL UNIT,LONDON W12 0NN,ENGLAND. ACAD HOSP JETTE,DEPT PATHOL,B-1090 BRUSSELS,BELGIUM. HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT SURG,LONDON W12 0NN,ENGLAND.
  • Pages: 1219-1223
    |
    Published online on: June 1, 1994
       https://doi.org/10.3892/ijo.4.6.1219
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Abstract

Growth factors may play a role in autocrine or paracrine growth control of tumour cells. We have now examined the expression pattern in vivo by in situ hybridization (ISH) on a series of 13 ductal adenocarcinomas of the pancreas using the non-radioactive digoxigenin system to generate specific antisense orientated riboprobes for FGF-1 and FGF-2, and the four FGFRs (FGFR-1, -2, -3 and -4). We confirmed the expression of both FGF/FGFR by tumour cells, with the potential of a potential autocrine loops in 46% of the cases studied. FGF-2 and FGFR-3 were the most commonly expressed ligand and receptor (46% and 76% respectively). Endothelial cells lining vessels within an around invasive tumours were frequently positive for expression of FGFR-1 and/or FGFR-3. In the normal pancreas remote from the tumour, the acinar cells were found to have a heterogeneous expression pattern for FGFRs while duct cells, islet cells and stromal components including nerves and vascular endothelium were negative. The data suggest a role for FGFs and their high affinity receptors in the control of growth of human pancreatic adenocarcinoma and its supporting stroma.

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Copy and paste a formatted citation
Spandidos Publications style
LEUNG H, HUGHES C, KLOPPEL G, WILLIAMSON R and LEMOINE N: LOCALIZATION OF EXPRESSION OF FIBROBLAST GROWTH-FACTORS AND THEIR RECEPTORS IN PANCREATIC ADENOCARCINOMA BY IN-SITU HYBRIDIZATION. Int J Oncol 4: 1219-1223, 1994.
APA
LEUNG, H., HUGHES, C., KLOPPEL, G., WILLIAMSON, R., & LEMOINE, N. (1994). LOCALIZATION OF EXPRESSION OF FIBROBLAST GROWTH-FACTORS AND THEIR RECEPTORS IN PANCREATIC ADENOCARCINOMA BY IN-SITU HYBRIDIZATION. International Journal of Oncology, 4, 1219-1223. https://doi.org/10.3892/ijo.4.6.1219
MLA
LEUNG, H., HUGHES, C., KLOPPEL, G., WILLIAMSON, R., LEMOINE, N."LOCALIZATION OF EXPRESSION OF FIBROBLAST GROWTH-FACTORS AND THEIR RECEPTORS IN PANCREATIC ADENOCARCINOMA BY IN-SITU HYBRIDIZATION". International Journal of Oncology 4.6 (1994): 1219-1223.
Chicago
LEUNG, H., HUGHES, C., KLOPPEL, G., WILLIAMSON, R., LEMOINE, N."LOCALIZATION OF EXPRESSION OF FIBROBLAST GROWTH-FACTORS AND THEIR RECEPTORS IN PANCREATIC ADENOCARCINOMA BY IN-SITU HYBRIDIZATION". International Journal of Oncology 4, no. 6 (1994): 1219-1223. https://doi.org/10.3892/ijo.4.6.1219
Copy and paste a formatted citation
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Spandidos Publications style
LEUNG H, HUGHES C, KLOPPEL G, WILLIAMSON R and LEMOINE N: LOCALIZATION OF EXPRESSION OF FIBROBLAST GROWTH-FACTORS AND THEIR RECEPTORS IN PANCREATIC ADENOCARCINOMA BY IN-SITU HYBRIDIZATION. Int J Oncol 4: 1219-1223, 1994.
APA
LEUNG, H., HUGHES, C., KLOPPEL, G., WILLIAMSON, R., & LEMOINE, N. (1994). LOCALIZATION OF EXPRESSION OF FIBROBLAST GROWTH-FACTORS AND THEIR RECEPTORS IN PANCREATIC ADENOCARCINOMA BY IN-SITU HYBRIDIZATION. International Journal of Oncology, 4, 1219-1223. https://doi.org/10.3892/ijo.4.6.1219
MLA
LEUNG, H., HUGHES, C., KLOPPEL, G., WILLIAMSON, R., LEMOINE, N."LOCALIZATION OF EXPRESSION OF FIBROBLAST GROWTH-FACTORS AND THEIR RECEPTORS IN PANCREATIC ADENOCARCINOMA BY IN-SITU HYBRIDIZATION". International Journal of Oncology 4.6 (1994): 1219-1223.
Chicago
LEUNG, H., HUGHES, C., KLOPPEL, G., WILLIAMSON, R., LEMOINE, N."LOCALIZATION OF EXPRESSION OF FIBROBLAST GROWTH-FACTORS AND THEIR RECEPTORS IN PANCREATIC ADENOCARCINOMA BY IN-SITU HYBRIDIZATION". International Journal of Oncology 4, no. 6 (1994): 1219-1223. https://doi.org/10.3892/ijo.4.6.1219
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