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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 1994 Volume 4 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 1994 Volume 4 Issue 6

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MULTIDRUG-RESISTANCE CIRCUMVENTION AND INHIBITION OF [H-3] AZIDOPINE PHOTOLABELING OF P-GLYCOPROTEIN BY NEW DIHYDROPYRIDINE DERIVATIVES DISPLAYING A LOW-AFFINITY FOR CALCIUM CHANNELS

  • Authors:
    • S LEONCE
    • A PIERRE
    • V PEREZ
    • N GUILBAUD
    • L KRAUS-BERTHIER
    • A GENTON
    • A LOMBET
    • JL PEGLION
    • G ATASSI

  • View Affiliations / Copyright

    Affiliations: INST RECH SERV,DIV RECH CANCEROL,11 RUE MOULINEAUX,F-92150 SURESNES,FRANCE. INST RECH SERV,DIV CHIM B,F-92150 SURESNES,FRANCE. INST RECH SERV,DIV BIOL MOLEC & CELLULAIRE,F-92150 SURESNES,FRANCE.
  • Pages: 1243-1250
    |
    Published online on: June 1, 1994
       https://doi.org/10.3892/ijo.4.6.1243
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Abstract

This study was aimed to characterize the reversing activity of S16209 and S16317, two new dihydropyridines with low affinity for calcium channels. In vivo, S16209 (75 mg/kg) and S16317 (25 mg/kg) potentiate the antitumor activity of vincristine (VCR) in VCR-resistant leukemia bearing mice. In vitro, a complete sensitization to adriamycin (ADR) or VCR is obtained with 2.5 muM of S16209 in S1/tMDR and KB-A1 cells and with 2.5 muM of S16317 in S1/tMDR and P388/ADR-10 cells. These two compounds are also more potent than verapamil and cyclosporin A in increasing actinomycin-D cytotoxicity in DC-3F/AD cells. In the presence of ADR or VCR, a 4 h co-incubation followed by a post-incubation of 20 h with 2.5 muM S16209 is sufficient to completely overcome the resistance of human KB-A1 and S1/tMDR cells to these cytotoxic drugs. S16209 and S16317 increase ADR accumulation in resistant cells, and completely inhibit the photolabeling of P-gp by [H-3]azidopine at 100 and 10 muM, respectively, suggesting that the reversing activity of these two compounds is mainly due to a specific inhibition of the P-gp mediated efflux of cytotoxic drugs.

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Copy and paste a formatted citation
Spandidos Publications style
LEONCE S, PIERRE A, PEREZ V, GUILBAUD N, KRAUS-BERTHIER L, GENTON A, LOMBET A, PEGLION J and ATASSI G: MULTIDRUG-RESISTANCE CIRCUMVENTION AND INHIBITION OF [H-3] AZIDOPINE PHOTOLABELING OF P-GLYCOPROTEIN BY NEW DIHYDROPYRIDINE DERIVATIVES DISPLAYING A LOW-AFFINITY FOR CALCIUM CHANNELS. Int J Oncol 4: 1243-1250, 1994.
APA
LEONCE, S., PIERRE, A., PEREZ, V., GUILBAUD, N., KRAUS-BERTHIER, L., GENTON, A. ... ATASSI, G. (1994). MULTIDRUG-RESISTANCE CIRCUMVENTION AND INHIBITION OF [H-3] AZIDOPINE PHOTOLABELING OF P-GLYCOPROTEIN BY NEW DIHYDROPYRIDINE DERIVATIVES DISPLAYING A LOW-AFFINITY FOR CALCIUM CHANNELS. International Journal of Oncology, 4, 1243-1250. https://doi.org/10.3892/ijo.4.6.1243
MLA
LEONCE, S., PIERRE, A., PEREZ, V., GUILBAUD, N., KRAUS-BERTHIER, L., GENTON, A., LOMBET, A., PEGLION, J., ATASSI, G."MULTIDRUG-RESISTANCE CIRCUMVENTION AND INHIBITION OF [H-3] AZIDOPINE PHOTOLABELING OF P-GLYCOPROTEIN BY NEW DIHYDROPYRIDINE DERIVATIVES DISPLAYING A LOW-AFFINITY FOR CALCIUM CHANNELS". International Journal of Oncology 4.6 (1994): 1243-1250.
Chicago
LEONCE, S., PIERRE, A., PEREZ, V., GUILBAUD, N., KRAUS-BERTHIER, L., GENTON, A., LOMBET, A., PEGLION, J., ATASSI, G."MULTIDRUG-RESISTANCE CIRCUMVENTION AND INHIBITION OF [H-3] AZIDOPINE PHOTOLABELING OF P-GLYCOPROTEIN BY NEW DIHYDROPYRIDINE DERIVATIVES DISPLAYING A LOW-AFFINITY FOR CALCIUM CHANNELS". International Journal of Oncology 4, no. 6 (1994): 1243-1250. https://doi.org/10.3892/ijo.4.6.1243
Copy and paste a formatted citation
x
Spandidos Publications style
LEONCE S, PIERRE A, PEREZ V, GUILBAUD N, KRAUS-BERTHIER L, GENTON A, LOMBET A, PEGLION J and ATASSI G: MULTIDRUG-RESISTANCE CIRCUMVENTION AND INHIBITION OF [H-3] AZIDOPINE PHOTOLABELING OF P-GLYCOPROTEIN BY NEW DIHYDROPYRIDINE DERIVATIVES DISPLAYING A LOW-AFFINITY FOR CALCIUM CHANNELS. Int J Oncol 4: 1243-1250, 1994.
APA
LEONCE, S., PIERRE, A., PEREZ, V., GUILBAUD, N., KRAUS-BERTHIER, L., GENTON, A. ... ATASSI, G. (1994). MULTIDRUG-RESISTANCE CIRCUMVENTION AND INHIBITION OF [H-3] AZIDOPINE PHOTOLABELING OF P-GLYCOPROTEIN BY NEW DIHYDROPYRIDINE DERIVATIVES DISPLAYING A LOW-AFFINITY FOR CALCIUM CHANNELS. International Journal of Oncology, 4, 1243-1250. https://doi.org/10.3892/ijo.4.6.1243
MLA
LEONCE, S., PIERRE, A., PEREZ, V., GUILBAUD, N., KRAUS-BERTHIER, L., GENTON, A., LOMBET, A., PEGLION, J., ATASSI, G."MULTIDRUG-RESISTANCE CIRCUMVENTION AND INHIBITION OF [H-3] AZIDOPINE PHOTOLABELING OF P-GLYCOPROTEIN BY NEW DIHYDROPYRIDINE DERIVATIVES DISPLAYING A LOW-AFFINITY FOR CALCIUM CHANNELS". International Journal of Oncology 4.6 (1994): 1243-1250.
Chicago
LEONCE, S., PIERRE, A., PEREZ, V., GUILBAUD, N., KRAUS-BERTHIER, L., GENTON, A., LOMBET, A., PEGLION, J., ATASSI, G."MULTIDRUG-RESISTANCE CIRCUMVENTION AND INHIBITION OF [H-3] AZIDOPINE PHOTOLABELING OF P-GLYCOPROTEIN BY NEW DIHYDROPYRIDINE DERIVATIVES DISPLAYING A LOW-AFFINITY FOR CALCIUM CHANNELS". International Journal of Oncology 4, no. 6 (1994): 1243-1250. https://doi.org/10.3892/ijo.4.6.1243
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