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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 1994 Volume 4 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 1994 Volume 4 Issue 6

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Article

DETECTION OF FOS, JUN AND RAS IN NEWLY-DIAGNOSED CHILDHOOD ACUTE LYMPHOBLASTIC-LEUKEMIA BY IMMUNOCYTOCHEMISTRY AND PCR

  • Authors:
    • M VOLM
    • A SAUERBREY
    • G STAMMLER
    • F ZINTL

  • View Affiliations / Copyright

    Affiliations: FRIEDRICH SCHILLER UNIV,CHILDRENS HOSP,O-6900 JENA,GERMANY.
  • Pages: 1251-1256
    |
    Published online on: June 1, 1994
       https://doi.org/10.3892/ijo.4.6.1251
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Abstract

The expression of the oncogenes c-fos, c-jun and c-pan-ras was analyzed at the protein level in newly diagnosed cases of acute lymphoblastic leukemia (ALL) in children. Blast cells obtained from 104 children with untreated ALL were determined by the streptavidin-biotin-peroxidase method and specific antibodies. Of the ALL 52 cases were positive for Fos (50%), 65 for Jun (63%), and 22 for Ras (21%). Fos-positive ALL had a significantly higher relapse frequency (p=0.0002). A similar trend was found for Jun-positive ALL (p=0.073). In contrast, the expression of Ras showed no significant correlation with the relapse rate (p=0.98). Corresponding results were obtained for the relapse-free intervals. The relapse-free intervals were higher in patients with Fos- and Jun-positive leukemic cells than in patients with negative tumor cells (Fos: p<0.001; Jun: p=0.09; Ras: p=NS, log-rank test). In order to substantiate the significant correlation of c-fos-protein expression with the relapse rate the c-fos-mRNA expression was investigated in a collective of 20 patients by semi-quantitative PCR. The PCR-assay and immunocytochemistry corresponded in 14 of 20 cases (70%). The results of the PCR-assay demonstrated also a trend for increased c-fos-mRNA expression and higher relapse rate.

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Copy and paste a formatted citation
Spandidos Publications style
VOLM M, SAUERBREY A, STAMMLER G and ZINTL F: DETECTION OF FOS, JUN AND RAS IN NEWLY-DIAGNOSED CHILDHOOD ACUTE LYMPHOBLASTIC-LEUKEMIA BY IMMUNOCYTOCHEMISTRY AND PCR. Int J Oncol 4: 1251-1256, 1994.
APA
VOLM, M., SAUERBREY, A., STAMMLER, G., & ZINTL, F. (1994). DETECTION OF FOS, JUN AND RAS IN NEWLY-DIAGNOSED CHILDHOOD ACUTE LYMPHOBLASTIC-LEUKEMIA BY IMMUNOCYTOCHEMISTRY AND PCR. International Journal of Oncology, 4, 1251-1256. https://doi.org/10.3892/ijo.4.6.1251
MLA
VOLM, M., SAUERBREY, A., STAMMLER, G., ZINTL, F."DETECTION OF FOS, JUN AND RAS IN NEWLY-DIAGNOSED CHILDHOOD ACUTE LYMPHOBLASTIC-LEUKEMIA BY IMMUNOCYTOCHEMISTRY AND PCR". International Journal of Oncology 4.6 (1994): 1251-1256.
Chicago
VOLM, M., SAUERBREY, A., STAMMLER, G., ZINTL, F."DETECTION OF FOS, JUN AND RAS IN NEWLY-DIAGNOSED CHILDHOOD ACUTE LYMPHOBLASTIC-LEUKEMIA BY IMMUNOCYTOCHEMISTRY AND PCR". International Journal of Oncology 4, no. 6 (1994): 1251-1256. https://doi.org/10.3892/ijo.4.6.1251
Copy and paste a formatted citation
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Spandidos Publications style
VOLM M, SAUERBREY A, STAMMLER G and ZINTL F: DETECTION OF FOS, JUN AND RAS IN NEWLY-DIAGNOSED CHILDHOOD ACUTE LYMPHOBLASTIC-LEUKEMIA BY IMMUNOCYTOCHEMISTRY AND PCR. Int J Oncol 4: 1251-1256, 1994.
APA
VOLM, M., SAUERBREY, A., STAMMLER, G., & ZINTL, F. (1994). DETECTION OF FOS, JUN AND RAS IN NEWLY-DIAGNOSED CHILDHOOD ACUTE LYMPHOBLASTIC-LEUKEMIA BY IMMUNOCYTOCHEMISTRY AND PCR. International Journal of Oncology, 4, 1251-1256. https://doi.org/10.3892/ijo.4.6.1251
MLA
VOLM, M., SAUERBREY, A., STAMMLER, G., ZINTL, F."DETECTION OF FOS, JUN AND RAS IN NEWLY-DIAGNOSED CHILDHOOD ACUTE LYMPHOBLASTIC-LEUKEMIA BY IMMUNOCYTOCHEMISTRY AND PCR". International Journal of Oncology 4.6 (1994): 1251-1256.
Chicago
VOLM, M., SAUERBREY, A., STAMMLER, G., ZINTL, F."DETECTION OF FOS, JUN AND RAS IN NEWLY-DIAGNOSED CHILDHOOD ACUTE LYMPHOBLASTIC-LEUKEMIA BY IMMUNOCYTOCHEMISTRY AND PCR". International Journal of Oncology 4, no. 6 (1994): 1251-1256. https://doi.org/10.3892/ijo.4.6.1251
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