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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 1994 Volume 4 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 1994 Volume 4 Issue 6

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Article

THE EFFECT OF FGF-3 INT-2 ON GROWTH AND TRANSFORMATION OF MCF-10A NORMAL HUMAN MAMMARY EPITHELIAL-CELLS IS DISTINCT FROM FGF-1 AND FGF-2

  • Authors:
    • F BASOLO
    • T VENESIO
    • S CALVO
    • L FIORE
    • G FONTANINI
    • F CIARDIELLO
    • A TONIOLO
    • DS LISCIA
    • GR MERLO

  • View Affiliations / Copyright

    Affiliations: S GIOVANNI HOSP, ANAT PATHOL SECT, I-10123 TURIN, ITALY. UNIV NAPOLI FEDERICO II, CATTEDRA ONCOL MED, I-80131 NAPLES, ITALY. UNIV PAVIA, SCH MED, INST MED & PUBL HLTH, I-21100 VARESE, ITALY. FRIEDRICH MIESCHER INST, CH-4002 BASEL, SWITZERLAND.
  • Pages: 1365-1370
    |
    Published online on: June 1, 1994
       https://doi.org/10.3892/ijo.4.6.1365
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Abstract

Fibroblast growth factors (FGFs) are related polypeptides with mitogenic activity on cells of mesodermal and neuroectodermal origin. The Fgf-3 gene shares high homology with FGF-2 and its protein product can substitute FGF-2 as a growth factor. Other observations, however, indicate that Fgf-3 has specialized functions. We have investigated the effect of the expression and secretion of Fgf-3 on the growth and transformation of the human breast epithelial cell line MCF-10A. Overexpression of Fgf-3 stimulates proliferation of these cells in serum-free medium and induces anchorage-independent colony formation in soft agar. In contrast, these effects were not observed with purified FGF-1 and FGF-2 on either the parental or the Fgf-3-MCF-10A cells. Thus, Fgf-3 is distinct from FGF-1 and FGF-2 for its ability to induce cell proliferation and transformation of MCF-10A cells. This difference could be due, at least in part, to the expression of a specific set of FGF receptors with higher affinity for FGF-3 than FGF-1 or FGF-2.

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Copy and paste a formatted citation
Spandidos Publications style
BASOLO F, VENESIO T, CALVO S, FIORE L, FONTANINI G, CIARDIELLO F, TONIOLO A, LISCIA D and MERLO G: THE EFFECT OF FGF-3 INT-2 ON GROWTH AND TRANSFORMATION OF MCF-10A NORMAL HUMAN MAMMARY EPITHELIAL-CELLS IS DISTINCT FROM FGF-1 AND FGF-2. Int J Oncol 4: 1365-1370, 1994.
APA
BASOLO, F., VENESIO, T., CALVO, S., FIORE, L., FONTANINI, G., CIARDIELLO, F. ... MERLO, G. (1994). THE EFFECT OF FGF-3 INT-2 ON GROWTH AND TRANSFORMATION OF MCF-10A NORMAL HUMAN MAMMARY EPITHELIAL-CELLS IS DISTINCT FROM FGF-1 AND FGF-2. International Journal of Oncology, 4, 1365-1370. https://doi.org/10.3892/ijo.4.6.1365
MLA
BASOLO, F., VENESIO, T., CALVO, S., FIORE, L., FONTANINI, G., CIARDIELLO, F., TONIOLO, A., LISCIA, D., MERLO, G."THE EFFECT OF FGF-3 INT-2 ON GROWTH AND TRANSFORMATION OF MCF-10A NORMAL HUMAN MAMMARY EPITHELIAL-CELLS IS DISTINCT FROM FGF-1 AND FGF-2". International Journal of Oncology 4.6 (1994): 1365-1370.
Chicago
BASOLO, F., VENESIO, T., CALVO, S., FIORE, L., FONTANINI, G., CIARDIELLO, F., TONIOLO, A., LISCIA, D., MERLO, G."THE EFFECT OF FGF-3 INT-2 ON GROWTH AND TRANSFORMATION OF MCF-10A NORMAL HUMAN MAMMARY EPITHELIAL-CELLS IS DISTINCT FROM FGF-1 AND FGF-2". International Journal of Oncology 4, no. 6 (1994): 1365-1370. https://doi.org/10.3892/ijo.4.6.1365
Copy and paste a formatted citation
x
Spandidos Publications style
BASOLO F, VENESIO T, CALVO S, FIORE L, FONTANINI G, CIARDIELLO F, TONIOLO A, LISCIA D and MERLO G: THE EFFECT OF FGF-3 INT-2 ON GROWTH AND TRANSFORMATION OF MCF-10A NORMAL HUMAN MAMMARY EPITHELIAL-CELLS IS DISTINCT FROM FGF-1 AND FGF-2. Int J Oncol 4: 1365-1370, 1994.
APA
BASOLO, F., VENESIO, T., CALVO, S., FIORE, L., FONTANINI, G., CIARDIELLO, F. ... MERLO, G. (1994). THE EFFECT OF FGF-3 INT-2 ON GROWTH AND TRANSFORMATION OF MCF-10A NORMAL HUMAN MAMMARY EPITHELIAL-CELLS IS DISTINCT FROM FGF-1 AND FGF-2. International Journal of Oncology, 4, 1365-1370. https://doi.org/10.3892/ijo.4.6.1365
MLA
BASOLO, F., VENESIO, T., CALVO, S., FIORE, L., FONTANINI, G., CIARDIELLO, F., TONIOLO, A., LISCIA, D., MERLO, G."THE EFFECT OF FGF-3 INT-2 ON GROWTH AND TRANSFORMATION OF MCF-10A NORMAL HUMAN MAMMARY EPITHELIAL-CELLS IS DISTINCT FROM FGF-1 AND FGF-2". International Journal of Oncology 4.6 (1994): 1365-1370.
Chicago
BASOLO, F., VENESIO, T., CALVO, S., FIORE, L., FONTANINI, G., CIARDIELLO, F., TONIOLO, A., LISCIA, D., MERLO, G."THE EFFECT OF FGF-3 INT-2 ON GROWTH AND TRANSFORMATION OF MCF-10A NORMAL HUMAN MAMMARY EPITHELIAL-CELLS IS DISTINCT FROM FGF-1 AND FGF-2". International Journal of Oncology 4, no. 6 (1994): 1365-1370. https://doi.org/10.3892/ijo.4.6.1365
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