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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 1994 Volume 5 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July 1994 Volume 5 Issue 1

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Article

NM23 EXPRESSION IN HUMAN GASTRIC CANCERS - POSSIBLE CORRELATION OF NM23 WITH LYMPH-NODE METASTASIS

  • Authors:
    • H MUTA
    • H IGUCHI
    • A KONO
    • Y SEO
    • H TOMODA
    • H NAWATA
  • View Affiliations / Copyright

    Affiliations: NATL KYUSHU CANC CTR,DEPT GASTROENTEROL,MINAMI KU,FUKUOKA 815,JAPAN. KYUSHU UNIV,FAC MED,DEPT INTERNAL MED 3,HIGASHI KU,FUKUOKA 812,JAPAN.
  • Pages: 93-96
    |
    Published online on: July 1, 1994
       https://doi.org/10.3892/ijo.5.1.93
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Abstract

In order to elucidate the relationship between nm23 and metastasis in human gastric cancers, we analyzed gene and protein expression of nm23-H1 using Northern blot and immunohistochemical techniques. nm23-H1 gene expression was identified in 17 out of 19 gastric cancer tissues. The signals in the tumor tissues presenting regional lymph node metastasis seem to be lower than those in the tumor tissues without regional lymph node metastasis, suggesting a role of nm23-H1 in the regional lymph node metastasis in the gastric cancers. However, the protein expression detected immunohistochemically was not correlated to the gene expression, partly because of difficulty in quantifying the amount of protein. Expression of the nm23-H1 gene as well as the nm23-H1 protein in the tumor tissues was higher than those in the corresponding normal mucosae. This suggests a linkage of nm23-H1 in the process of the gastric cancer progression. We also analyzed the sequence abnormalities of the nm23-H1 gene in the gastric cancer tissues using a direct sequencing technique, no mutations were observed.

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Copy and paste a formatted citation
Spandidos Publications style
MUTA H, IGUCHI H, KONO A, SEO Y, TOMODA H and NAWATA H: NM23 EXPRESSION IN HUMAN GASTRIC CANCERS - POSSIBLE CORRELATION OF NM23 WITH LYMPH-NODE METASTASIS. Int J Oncol 5: 93-96, 1994.
APA
MUTA, H., IGUCHI, H., KONO, A., SEO, Y., TOMODA, H., & NAWATA, H. (1994). NM23 EXPRESSION IN HUMAN GASTRIC CANCERS - POSSIBLE CORRELATION OF NM23 WITH LYMPH-NODE METASTASIS. International Journal of Oncology, 5, 93-96. https://doi.org/10.3892/ijo.5.1.93
MLA
MUTA, H., IGUCHI, H., KONO, A., SEO, Y., TOMODA, H., NAWATA, H."NM23 EXPRESSION IN HUMAN GASTRIC CANCERS - POSSIBLE CORRELATION OF NM23 WITH LYMPH-NODE METASTASIS". International Journal of Oncology 5.1 (1994): 93-96.
Chicago
MUTA, H., IGUCHI, H., KONO, A., SEO, Y., TOMODA, H., NAWATA, H."NM23 EXPRESSION IN HUMAN GASTRIC CANCERS - POSSIBLE CORRELATION OF NM23 WITH LYMPH-NODE METASTASIS". International Journal of Oncology 5, no. 1 (1994): 93-96. https://doi.org/10.3892/ijo.5.1.93
Copy and paste a formatted citation
x
Spandidos Publications style
MUTA H, IGUCHI H, KONO A, SEO Y, TOMODA H and NAWATA H: NM23 EXPRESSION IN HUMAN GASTRIC CANCERS - POSSIBLE CORRELATION OF NM23 WITH LYMPH-NODE METASTASIS. Int J Oncol 5: 93-96, 1994.
APA
MUTA, H., IGUCHI, H., KONO, A., SEO, Y., TOMODA, H., & NAWATA, H. (1994). NM23 EXPRESSION IN HUMAN GASTRIC CANCERS - POSSIBLE CORRELATION OF NM23 WITH LYMPH-NODE METASTASIS. International Journal of Oncology, 5, 93-96. https://doi.org/10.3892/ijo.5.1.93
MLA
MUTA, H., IGUCHI, H., KONO, A., SEO, Y., TOMODA, H., NAWATA, H."NM23 EXPRESSION IN HUMAN GASTRIC CANCERS - POSSIBLE CORRELATION OF NM23 WITH LYMPH-NODE METASTASIS". International Journal of Oncology 5.1 (1994): 93-96.
Chicago
MUTA, H., IGUCHI, H., KONO, A., SEO, Y., TOMODA, H., NAWATA, H."NM23 EXPRESSION IN HUMAN GASTRIC CANCERS - POSSIBLE CORRELATION OF NM23 WITH LYMPH-NODE METASTASIS". International Journal of Oncology 5, no. 1 (1994): 93-96. https://doi.org/10.3892/ijo.5.1.93
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