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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 1994 Volume 5 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 1994 Volume 5 Issue 2

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ADOPTIVE TRANSFER OF PROTECTIVE IMMUNITY AGAINST A HIGH METASTATIC TUMOR-CELL VARIANT BY SMALL NUMBERS OF TUMOR-SPECIFIC IN-SITU ACTIVATED PERITONEAL EFFECTOR T-CELLS

  • Authors:
    • V SCHIRRMACHER
    • A GRIESBACH
    • V UMANSKY
    • M ROCHA

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    Affiliations: Affliations not specified
  • Pages: 141-151
    |
    Published online on: August 1, 1994
       https://doi.org/10.3892/ijo.5.2.141
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Abstract

We describe the generation and immunotherapeutic properties of syngeneic immune T cells activated in situ against the lymphoma variant ESb which metastasizes to multiple organs (liver, lung, spleen, bone) and can develop sophisticated immune escape mechanisms. Peritoneal effector cells (PEC) generated from intra-pinna tumor immunized and i.p. restimulated mice were able to transfer protective immunity in the absence of exogenous cytokines into normal or 5Gy irradiated or SCID mice which had been injected either s.c. or i.v. with 5x10(3) to 10(5) metastatic ESb tumor cells. Protective immunity was specific for ESb cells and could be followed by growth retardation of s.c. tumors as well as by prevention or retardation of death from metastases. Expression of protective immunity was independent of host T cells since it was similarly expressed in SCID-mice and sublethally irradiated mice. Preincubation in vitro for 24 h of the PEC before adoptive transfer led to pronounced decrease of protective immunity while the tumor specific cytotoxic T lymphocyte (CTL) activity was maintained or even enhanced. These results demonstrate i) that protective immunity in vivo requires more than tumor specific cytotoxic activity and ii) that in vitro culture of immune cells can change their in vivo functional properties.

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Copy and paste a formatted citation
Spandidos Publications style
SCHIRRMACHER V, GRIESBACH A, UMANSKY V and ROCHA M: ADOPTIVE TRANSFER OF PROTECTIVE IMMUNITY AGAINST A HIGH METASTATIC TUMOR-CELL VARIANT BY SMALL NUMBERS OF TUMOR-SPECIFIC IN-SITU ACTIVATED PERITONEAL EFFECTOR T-CELLS. Int J Oncol 5: 141-151, 1994.
APA
SCHIRRMACHER, V., GRIESBACH, A., UMANSKY, V., & ROCHA, M. (1994). ADOPTIVE TRANSFER OF PROTECTIVE IMMUNITY AGAINST A HIGH METASTATIC TUMOR-CELL VARIANT BY SMALL NUMBERS OF TUMOR-SPECIFIC IN-SITU ACTIVATED PERITONEAL EFFECTOR T-CELLS. International Journal of Oncology, 5, 141-151. https://doi.org/10.3892/ijo.5.2.141
MLA
SCHIRRMACHER, V., GRIESBACH, A., UMANSKY, V., ROCHA, M."ADOPTIVE TRANSFER OF PROTECTIVE IMMUNITY AGAINST A HIGH METASTATIC TUMOR-CELL VARIANT BY SMALL NUMBERS OF TUMOR-SPECIFIC IN-SITU ACTIVATED PERITONEAL EFFECTOR T-CELLS". International Journal of Oncology 5.2 (1994): 141-151.
Chicago
SCHIRRMACHER, V., GRIESBACH, A., UMANSKY, V., ROCHA, M."ADOPTIVE TRANSFER OF PROTECTIVE IMMUNITY AGAINST A HIGH METASTATIC TUMOR-CELL VARIANT BY SMALL NUMBERS OF TUMOR-SPECIFIC IN-SITU ACTIVATED PERITONEAL EFFECTOR T-CELLS". International Journal of Oncology 5, no. 2 (1994): 141-151. https://doi.org/10.3892/ijo.5.2.141
Copy and paste a formatted citation
x
Spandidos Publications style
SCHIRRMACHER V, GRIESBACH A, UMANSKY V and ROCHA M: ADOPTIVE TRANSFER OF PROTECTIVE IMMUNITY AGAINST A HIGH METASTATIC TUMOR-CELL VARIANT BY SMALL NUMBERS OF TUMOR-SPECIFIC IN-SITU ACTIVATED PERITONEAL EFFECTOR T-CELLS. Int J Oncol 5: 141-151, 1994.
APA
SCHIRRMACHER, V., GRIESBACH, A., UMANSKY, V., & ROCHA, M. (1994). ADOPTIVE TRANSFER OF PROTECTIVE IMMUNITY AGAINST A HIGH METASTATIC TUMOR-CELL VARIANT BY SMALL NUMBERS OF TUMOR-SPECIFIC IN-SITU ACTIVATED PERITONEAL EFFECTOR T-CELLS. International Journal of Oncology, 5, 141-151. https://doi.org/10.3892/ijo.5.2.141
MLA
SCHIRRMACHER, V., GRIESBACH, A., UMANSKY, V., ROCHA, M."ADOPTIVE TRANSFER OF PROTECTIVE IMMUNITY AGAINST A HIGH METASTATIC TUMOR-CELL VARIANT BY SMALL NUMBERS OF TUMOR-SPECIFIC IN-SITU ACTIVATED PERITONEAL EFFECTOR T-CELLS". International Journal of Oncology 5.2 (1994): 141-151.
Chicago
SCHIRRMACHER, V., GRIESBACH, A., UMANSKY, V., ROCHA, M."ADOPTIVE TRANSFER OF PROTECTIVE IMMUNITY AGAINST A HIGH METASTATIC TUMOR-CELL VARIANT BY SMALL NUMBERS OF TUMOR-SPECIFIC IN-SITU ACTIVATED PERITONEAL EFFECTOR T-CELLS". International Journal of Oncology 5, no. 2 (1994): 141-151. https://doi.org/10.3892/ijo.5.2.141
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