ADOPTIVE IMMUNOTHERAPY OF EXPERIMENTAL OVARIAN-CANCER USING ACTIVATED HUMAN MONOCYTES AND THE HUMAN MONOCLONAL-ANTIBODY, ANTI-14C1

  • Authors:
    • G GALLAGHER
    • F ALAZZAWI
  • View Affiliations

  • Published online on: August 1, 1994     https://doi.org/10.3892/ijo.5.2.253
  • Pages: 253-258
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Abstract

We have examined the ability of the ovarian cancer cell-line OWmM1 to grow intraperitoneally in athymic ('nude') mice. The cell-line was tumorigenic and metastatic in a manner that paralleled the human disease; the metastatic nodules implanted onto the peritoneal surface, the diaphragm and the mesentery. The resulting tumour formed a clear ascitic fluid and peritoneal carcinomatosis. Adoptive transfer of activated human monocytes to the peritoneal cavity of tumour-bearing animals showed no increase in survival, while antibody alone produced a modest survival benefit (2-4 days). Administration of the human monoclonal antibody anti-14C1 and monocyte therapy together increased the benefit further and resulted in approximately 30% of the animals surviving until the end of the experiment (100 days).

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August 1994
Volume 5 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
GALLAGHER G and GALLAGHER G: ADOPTIVE IMMUNOTHERAPY OF EXPERIMENTAL OVARIAN-CANCER USING ACTIVATED HUMAN MONOCYTES AND THE HUMAN MONOCLONAL-ANTIBODY, ANTI-14C1. Int J Oncol 5: 253-258, 1994
APA
GALLAGHER, G., & GALLAGHER, G. (1994). ADOPTIVE IMMUNOTHERAPY OF EXPERIMENTAL OVARIAN-CANCER USING ACTIVATED HUMAN MONOCYTES AND THE HUMAN MONOCLONAL-ANTIBODY, ANTI-14C1. International Journal of Oncology, 5, 253-258. https://doi.org/10.3892/ijo.5.2.253
MLA
GALLAGHER, G., ALAZZAWI, F."ADOPTIVE IMMUNOTHERAPY OF EXPERIMENTAL OVARIAN-CANCER USING ACTIVATED HUMAN MONOCYTES AND THE HUMAN MONOCLONAL-ANTIBODY, ANTI-14C1". International Journal of Oncology 5.2 (1994): 253-258.
Chicago
GALLAGHER, G., ALAZZAWI, F."ADOPTIVE IMMUNOTHERAPY OF EXPERIMENTAL OVARIAN-CANCER USING ACTIVATED HUMAN MONOCYTES AND THE HUMAN MONOCLONAL-ANTIBODY, ANTI-14C1". International Journal of Oncology 5, no. 2 (1994): 253-258. https://doi.org/10.3892/ijo.5.2.253