6Q(-) AS THE ONLY CYTOGENETIC ABERRATION - LOSS OF 6Q23 AND SURVIVAL IN HEMATOLOGIC MALIGNANCIES

  • Authors:
    • B PEDERSEN
    • SAF HAMMOUDAH
    • PD JENSEN
  • View Affiliations

  • Published online on: August 1, 1994     https://doi.org/10.3892/ijo.5.2.321
  • Pages: 321-327
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Abstract

Deletion of a segment of the long arm of chromosome 6 (6q-) is relatively frequent in lymphoid leukemias and malignant lymphomas, but rare in myeloid leukemias and myelodysplastic syndromes. The possible clinical consequences of 6q deletions are unknown. We hav approached this problem by looking for relations between loss of 6q bands and clinical as well as hematological parameters in patients with hematological malignancies. We found that survival was significantly shorter and the 6-q-metaphase prevalences significantly higher when 6q23 had been deleted. No other 6q band showed non-random associations. A candidate tumor suppressor gene may be encoded in 6q23.

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August 1994
Volume 5 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
PEDERSEN B, HAMMOUDAH S and JENSEN P: 6Q(-) AS THE ONLY CYTOGENETIC ABERRATION - LOSS OF 6Q23 AND SURVIVAL IN HEMATOLOGIC MALIGNANCIES. Int J Oncol 5: 321-327, 1994
APA
PEDERSEN, B., HAMMOUDAH, S., & JENSEN, P. (1994). 6Q(-) AS THE ONLY CYTOGENETIC ABERRATION - LOSS OF 6Q23 AND SURVIVAL IN HEMATOLOGIC MALIGNANCIES. International Journal of Oncology, 5, 321-327. https://doi.org/10.3892/ijo.5.2.321
MLA
PEDERSEN, B., HAMMOUDAH, S., JENSEN, P."6Q(-) AS THE ONLY CYTOGENETIC ABERRATION - LOSS OF 6Q23 AND SURVIVAL IN HEMATOLOGIC MALIGNANCIES". International Journal of Oncology 5.2 (1994): 321-327.
Chicago
PEDERSEN, B., HAMMOUDAH, S., JENSEN, P."6Q(-) AS THE ONLY CYTOGENETIC ABERRATION - LOSS OF 6Q23 AND SURVIVAL IN HEMATOLOGIC MALIGNANCIES". International Journal of Oncology 5, no. 2 (1994): 321-327. https://doi.org/10.3892/ijo.5.2.321