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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 1994 Volume 5 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 1994 Volume 5 Issue 4

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Article

EFFECT OF RHG-CSF (FILGRASTIM) ON LEUKOCYTE KINETICS AND IMMUNE FUNCTION IN CYTOTOXIC CHEMOTHERAPY FOR GYNECOLOGIC MALIGNANCIES

  • Authors:
    • N TAKESHIMA
    • S UMEZAWA
    • Y SHIMIZU
    • M FUKUDA
    • M KIMURA
    • K HASUMI

  • View Affiliations / Copyright

    Affiliations: KIRIN BREWERY CO LTD,DIV PHARMACEUT,TOKYO,JAPAN. SANKYO CO LTD,DIV SCI,TOKYO 140,JAPAN.
  • Pages: 827-831
    |
    Published online on: October 1, 1994
       https://doi.org/10.3892/ijo.5.4.827
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Abstract

The effects of human recombinant granulocyte colony-stimulating factor (rhG-CSF) on leukocyte kinetics and immune function were assessed in patients with gynecologic malignancies receiving cytotoxic chemotherapy. Five day-rhG-CSF administration (50 mu g/m(2)/day) increased leukocyte counts in most of the chemotherapy courses. There was a significant difference in the leukocyte increase between the previously irradiated group and the nonirradiated group. An appreciable increase in LAK activity owing to an increased IL-2 production was noted after rhG-CSF administration. Despite a remarkable increase in the neutrophils observed, the CD57(+) cell count and NK activity in peripheral blood mononuclear cells were unexpectedly reduced.

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Copy and paste a formatted citation
Spandidos Publications style
TAKESHIMA N, UMEZAWA S, SHIMIZU Y, FUKUDA M, KIMURA M and HASUMI K: EFFECT OF RHG-CSF (FILGRASTIM) ON LEUKOCYTE KINETICS AND IMMUNE FUNCTION IN CYTOTOXIC CHEMOTHERAPY FOR GYNECOLOGIC MALIGNANCIES. Int J Oncol 5: 827-831, 1994.
APA
TAKESHIMA, N., UMEZAWA, S., SHIMIZU, Y., FUKUDA, M., KIMURA, M., & HASUMI, K. (1994). EFFECT OF RHG-CSF (FILGRASTIM) ON LEUKOCYTE KINETICS AND IMMUNE FUNCTION IN CYTOTOXIC CHEMOTHERAPY FOR GYNECOLOGIC MALIGNANCIES. International Journal of Oncology, 5, 827-831. https://doi.org/10.3892/ijo.5.4.827
MLA
TAKESHIMA, N., UMEZAWA, S., SHIMIZU, Y., FUKUDA, M., KIMURA, M., HASUMI, K."EFFECT OF RHG-CSF (FILGRASTIM) ON LEUKOCYTE KINETICS AND IMMUNE FUNCTION IN CYTOTOXIC CHEMOTHERAPY FOR GYNECOLOGIC MALIGNANCIES". International Journal of Oncology 5.4 (1994): 827-831.
Chicago
TAKESHIMA, N., UMEZAWA, S., SHIMIZU, Y., FUKUDA, M., KIMURA, M., HASUMI, K."EFFECT OF RHG-CSF (FILGRASTIM) ON LEUKOCYTE KINETICS AND IMMUNE FUNCTION IN CYTOTOXIC CHEMOTHERAPY FOR GYNECOLOGIC MALIGNANCIES". International Journal of Oncology 5, no. 4 (1994): 827-831. https://doi.org/10.3892/ijo.5.4.827
Copy and paste a formatted citation
x
Spandidos Publications style
TAKESHIMA N, UMEZAWA S, SHIMIZU Y, FUKUDA M, KIMURA M and HASUMI K: EFFECT OF RHG-CSF (FILGRASTIM) ON LEUKOCYTE KINETICS AND IMMUNE FUNCTION IN CYTOTOXIC CHEMOTHERAPY FOR GYNECOLOGIC MALIGNANCIES. Int J Oncol 5: 827-831, 1994.
APA
TAKESHIMA, N., UMEZAWA, S., SHIMIZU, Y., FUKUDA, M., KIMURA, M., & HASUMI, K. (1994). EFFECT OF RHG-CSF (FILGRASTIM) ON LEUKOCYTE KINETICS AND IMMUNE FUNCTION IN CYTOTOXIC CHEMOTHERAPY FOR GYNECOLOGIC MALIGNANCIES. International Journal of Oncology, 5, 827-831. https://doi.org/10.3892/ijo.5.4.827
MLA
TAKESHIMA, N., UMEZAWA, S., SHIMIZU, Y., FUKUDA, M., KIMURA, M., HASUMI, K."EFFECT OF RHG-CSF (FILGRASTIM) ON LEUKOCYTE KINETICS AND IMMUNE FUNCTION IN CYTOTOXIC CHEMOTHERAPY FOR GYNECOLOGIC MALIGNANCIES". International Journal of Oncology 5.4 (1994): 827-831.
Chicago
TAKESHIMA, N., UMEZAWA, S., SHIMIZU, Y., FUKUDA, M., KIMURA, M., HASUMI, K."EFFECT OF RHG-CSF (FILGRASTIM) ON LEUKOCYTE KINETICS AND IMMUNE FUNCTION IN CYTOTOXIC CHEMOTHERAPY FOR GYNECOLOGIC MALIGNANCIES". International Journal of Oncology 5, no. 4 (1994): 827-831. https://doi.org/10.3892/ijo.5.4.827
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