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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 1994 Volume 5 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 1994 Volume 5 Issue 5

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Article

DISTRIBUTION OF RETINOIC ACID RECEPTOR-ALPHA, RECEPTOR-BETA AND RECEPTOR-GAMMA MESSENGER-RNAS IN NEUROBLASTOMA-DERIVED CELL-LINES AND IN FRESH TUMORS

  • Authors:
    • N FERRARI
    • GP TONINI
    • A BRIATA
    • F BOTTINI
    • G VIDALI

  • View Affiliations / Copyright

    Affiliations: IST NAZL RIC CANC,MOLEC BIOL LAB,I-16132 GENOA,ITALY. G GASLINI CHILDRENS HOSP,ONCOL LAB,I-16132 GENOA,ITALY. G GASLINI CHILDRENS HOSP,DEPT HEMATOL & ONCOL,I-16132 GENOA,ITALY.
  • Pages: 1019-1022
    |
    Published online on: November 1, 1994
       https://doi.org/10.3892/ijo.5.5.1019
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Abstract

The expression of alpha, beta and gamma retinoic acid receptors (RAR) was analyzed by reverse transcription polymerase chain reaction (RT/PCR) in several neuroblastoma derived cell lines before and after exposure to 10 nM retinoic acid. Each cell line shows a different receptor pattern: RAR alpha mRNA is ubiquitously present, whereas RAR beta and RAR gamma mRNAs are not always expressed. After retinoic acid treatment at physiological concentration, the majority of cell lines shows expression of all three receptors but two are resistant to the retinoid in expressing RAR beta mRNA. These data suggest that each NB cell line follows a particular retinoic acid-dependent differentiation route, at least with regard to the expression of RAR alpha, beta and gamma receptors. In an attempt to develop a biochemical classification of neuroblastomas, which could also be useful in the prognosis of the disease, we have screened biopsies belonging to patients in different clinical stages for the distribution of RAR receptors. The results show that the pattern of RAR alpha, beta and gamma mRNAs expression is rather variable in fresh tumors even if they are classified at the same stage. This may account for heterogeneous tumor cell composition which has in turn its own complement of RA receptors.

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Copy and paste a formatted citation
Spandidos Publications style
FERRARI N, TONINI G, BRIATA A, BOTTINI F and VIDALI G: DISTRIBUTION OF RETINOIC ACID RECEPTOR-ALPHA, RECEPTOR-BETA AND RECEPTOR-GAMMA MESSENGER-RNAS IN NEUROBLASTOMA-DERIVED CELL-LINES AND IN FRESH TUMORS. Int J Oncol 5: 1019-1022, 1994.
APA
FERRARI, N., TONINI, G., BRIATA, A., BOTTINI, F., & VIDALI, G. (1994). DISTRIBUTION OF RETINOIC ACID RECEPTOR-ALPHA, RECEPTOR-BETA AND RECEPTOR-GAMMA MESSENGER-RNAS IN NEUROBLASTOMA-DERIVED CELL-LINES AND IN FRESH TUMORS. International Journal of Oncology, 5, 1019-1022. https://doi.org/10.3892/ijo.5.5.1019
MLA
FERRARI, N., TONINI, G., BRIATA, A., BOTTINI, F., VIDALI, G."DISTRIBUTION OF RETINOIC ACID RECEPTOR-ALPHA, RECEPTOR-BETA AND RECEPTOR-GAMMA MESSENGER-RNAS IN NEUROBLASTOMA-DERIVED CELL-LINES AND IN FRESH TUMORS". International Journal of Oncology 5.5 (1994): 1019-1022.
Chicago
FERRARI, N., TONINI, G., BRIATA, A., BOTTINI, F., VIDALI, G."DISTRIBUTION OF RETINOIC ACID RECEPTOR-ALPHA, RECEPTOR-BETA AND RECEPTOR-GAMMA MESSENGER-RNAS IN NEUROBLASTOMA-DERIVED CELL-LINES AND IN FRESH TUMORS". International Journal of Oncology 5, no. 5 (1994): 1019-1022. https://doi.org/10.3892/ijo.5.5.1019
Copy and paste a formatted citation
x
Spandidos Publications style
FERRARI N, TONINI G, BRIATA A, BOTTINI F and VIDALI G: DISTRIBUTION OF RETINOIC ACID RECEPTOR-ALPHA, RECEPTOR-BETA AND RECEPTOR-GAMMA MESSENGER-RNAS IN NEUROBLASTOMA-DERIVED CELL-LINES AND IN FRESH TUMORS. Int J Oncol 5: 1019-1022, 1994.
APA
FERRARI, N., TONINI, G., BRIATA, A., BOTTINI, F., & VIDALI, G. (1994). DISTRIBUTION OF RETINOIC ACID RECEPTOR-ALPHA, RECEPTOR-BETA AND RECEPTOR-GAMMA MESSENGER-RNAS IN NEUROBLASTOMA-DERIVED CELL-LINES AND IN FRESH TUMORS. International Journal of Oncology, 5, 1019-1022. https://doi.org/10.3892/ijo.5.5.1019
MLA
FERRARI, N., TONINI, G., BRIATA, A., BOTTINI, F., VIDALI, G."DISTRIBUTION OF RETINOIC ACID RECEPTOR-ALPHA, RECEPTOR-BETA AND RECEPTOR-GAMMA MESSENGER-RNAS IN NEUROBLASTOMA-DERIVED CELL-LINES AND IN FRESH TUMORS". International Journal of Oncology 5.5 (1994): 1019-1022.
Chicago
FERRARI, N., TONINI, G., BRIATA, A., BOTTINI, F., VIDALI, G."DISTRIBUTION OF RETINOIC ACID RECEPTOR-ALPHA, RECEPTOR-BETA AND RECEPTOR-GAMMA MESSENGER-RNAS IN NEUROBLASTOMA-DERIVED CELL-LINES AND IN FRESH TUMORS". International Journal of Oncology 5, no. 5 (1994): 1019-1022. https://doi.org/10.3892/ijo.5.5.1019
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