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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 1994 Volume 5 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 1994 Volume 5 Issue 5

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REVERSION OF P-GLYCOPROTEIN MEDIATED MULTIDRUG-RESISTANCE TO VINCRISTINE AND ADRIAMYCIN BY PSC-833, A CYCLOSPORINE DERIVATIVE IN HUMAN NEUROBLASTOMA CELL-LINES

  • Authors:
    • C HELSON
    • Z ZAHN
    • L HELSON

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    Affiliations: NCI,BETHESDA,MD 20892.
  • Pages: 1037-1042
    |
    Published online on: November 1, 1994
       https://doi.org/10.3892/ijo.5.5.1037
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Abstract

We evaluated the effect of PSC-833 a cyclosporine derivative for its MDR1 reversing activity on vincristine and adriamycin resistance in human neuroblastoma cell lines. The cell lines have high, intermittent and low MDR1 expression. Resistance to vincristine and adriamycin was inverse to the degree of MDR1 expression. Resistance could be lowered with longer exposures to drug in all three cell lines. PSC-833 was able to reverse resistance in the SK-N-FI cells to a greater degree than in the two cell lines with lower expression of MDR1. These data suggest that MDR1 may play a protective role against vincristine and adriamycin in human neuroblastoma cells, and PSC-833 can reverse this protection. The duration of exposure to drug alters the response and the effect of PSC-833 on reversal of resistance. Where MDR1 is minimally expressed, PSC-833 is ineffective. Overall activity of vincristine and its modulation by PSC-833 were more consistent than that of adriamycin. Multiple drug resistance mechanisms are complex and vary among different cell lines when challenged with MDR1 drugs and reversing agents.

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Copy and paste a formatted citation
Spandidos Publications style
HELSON C, ZAHN Z and HELSON L: REVERSION OF P-GLYCOPROTEIN MEDIATED MULTIDRUG-RESISTANCE TO VINCRISTINE AND ADRIAMYCIN BY PSC-833, A CYCLOSPORINE DERIVATIVE IN HUMAN NEUROBLASTOMA CELL-LINES. Int J Oncol 5: 1037-1042, 1994.
APA
HELSON, C., ZAHN, Z., & HELSON, L. (1994). REVERSION OF P-GLYCOPROTEIN MEDIATED MULTIDRUG-RESISTANCE TO VINCRISTINE AND ADRIAMYCIN BY PSC-833, A CYCLOSPORINE DERIVATIVE IN HUMAN NEUROBLASTOMA CELL-LINES. International Journal of Oncology, 5, 1037-1042. https://doi.org/10.3892/ijo.5.5.1037
MLA
HELSON, C., ZAHN, Z., HELSON, L."REVERSION OF P-GLYCOPROTEIN MEDIATED MULTIDRUG-RESISTANCE TO VINCRISTINE AND ADRIAMYCIN BY PSC-833, A CYCLOSPORINE DERIVATIVE IN HUMAN NEUROBLASTOMA CELL-LINES". International Journal of Oncology 5.5 (1994): 1037-1042.
Chicago
HELSON, C., ZAHN, Z., HELSON, L."REVERSION OF P-GLYCOPROTEIN MEDIATED MULTIDRUG-RESISTANCE TO VINCRISTINE AND ADRIAMYCIN BY PSC-833, A CYCLOSPORINE DERIVATIVE IN HUMAN NEUROBLASTOMA CELL-LINES". International Journal of Oncology 5, no. 5 (1994): 1037-1042. https://doi.org/10.3892/ijo.5.5.1037
Copy and paste a formatted citation
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Spandidos Publications style
HELSON C, ZAHN Z and HELSON L: REVERSION OF P-GLYCOPROTEIN MEDIATED MULTIDRUG-RESISTANCE TO VINCRISTINE AND ADRIAMYCIN BY PSC-833, A CYCLOSPORINE DERIVATIVE IN HUMAN NEUROBLASTOMA CELL-LINES. Int J Oncol 5: 1037-1042, 1994.
APA
HELSON, C., ZAHN, Z., & HELSON, L. (1994). REVERSION OF P-GLYCOPROTEIN MEDIATED MULTIDRUG-RESISTANCE TO VINCRISTINE AND ADRIAMYCIN BY PSC-833, A CYCLOSPORINE DERIVATIVE IN HUMAN NEUROBLASTOMA CELL-LINES. International Journal of Oncology, 5, 1037-1042. https://doi.org/10.3892/ijo.5.5.1037
MLA
HELSON, C., ZAHN, Z., HELSON, L."REVERSION OF P-GLYCOPROTEIN MEDIATED MULTIDRUG-RESISTANCE TO VINCRISTINE AND ADRIAMYCIN BY PSC-833, A CYCLOSPORINE DERIVATIVE IN HUMAN NEUROBLASTOMA CELL-LINES". International Journal of Oncology 5.5 (1994): 1037-1042.
Chicago
HELSON, C., ZAHN, Z., HELSON, L."REVERSION OF P-GLYCOPROTEIN MEDIATED MULTIDRUG-RESISTANCE TO VINCRISTINE AND ADRIAMYCIN BY PSC-833, A CYCLOSPORINE DERIVATIVE IN HUMAN NEUROBLASTOMA CELL-LINES". International Journal of Oncology 5, no. 5 (1994): 1037-1042. https://doi.org/10.3892/ijo.5.5.1037
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