SERUM CYTOKERATIN-19 MEASURED BY CYFRA21-1 ASSAY IN PATIENTS WITH GASTROINTESTINAL AND GYNECOLOGIC MALIGNANCY

  • Authors:
    • H SAKAHARA
    • T KOUSAKA
    • H KOBAYASHI
    • ZS YAO
    • M IMAMURA
    • T MORI
    • J KONISHI
  • View Affiliations

  • Published online on: November 1, 1994     https://doi.org/10.3892/ijo.5.5.1137
  • Pages: 1137-1140
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Abstract

The serum fragment of cytokeratin 19 was measured in 130 patients with gastrointestinal, breast and gynecologic cancer and 62 patients with benign disease using CYFRA21-1 immunoradiometric assay. Patients with advanced cancer showed the highest level of serum CYFRA21-1. When the cut-off level was set at 2 ng/ml, 7 of 61 patients with earlier stage cancer were positive whereas 45 of 69 patients with advanced cancer had serum CYFRA21-1 levels over 2 ng/ml. In benign gastrointestinal and gynecologic diseases, 4 of 66 patients were positive. Retrospective evaluation revealed a good correlation between the serum CYFRA21-1 concentration and clinical course. CYFRA21-1 may be a useful tumor marker for monitoring of gastrointestinal and gynecologic malignancies.

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November 1994
Volume 5 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
SAKAHARA H, KOUSAKA T, KOBAYASHI H, YAO Z, IMAMURA M, MORI T and KONISHI J: SERUM CYTOKERATIN-19 MEASURED BY CYFRA21-1 ASSAY IN PATIENTS WITH GASTROINTESTINAL AND GYNECOLOGIC MALIGNANCY. Int J Oncol 5: 1137-1140, 1994
APA
SAKAHARA, H., KOUSAKA, T., KOBAYASHI, H., YAO, Z., IMAMURA, M., MORI, T., & KONISHI, J. (1994). SERUM CYTOKERATIN-19 MEASURED BY CYFRA21-1 ASSAY IN PATIENTS WITH GASTROINTESTINAL AND GYNECOLOGIC MALIGNANCY. International Journal of Oncology, 5, 1137-1140. https://doi.org/10.3892/ijo.5.5.1137
MLA
SAKAHARA, H., KOUSAKA, T., KOBAYASHI, H., YAO, Z., IMAMURA, M., MORI, T., KONISHI, J."SERUM CYTOKERATIN-19 MEASURED BY CYFRA21-1 ASSAY IN PATIENTS WITH GASTROINTESTINAL AND GYNECOLOGIC MALIGNANCY". International Journal of Oncology 5.5 (1994): 1137-1140.
Chicago
SAKAHARA, H., KOUSAKA, T., KOBAYASHI, H., YAO, Z., IMAMURA, M., MORI, T., KONISHI, J."SERUM CYTOKERATIN-19 MEASURED BY CYFRA21-1 ASSAY IN PATIENTS WITH GASTROINTESTINAL AND GYNECOLOGIC MALIGNANCY". International Journal of Oncology 5, no. 5 (1994): 1137-1140. https://doi.org/10.3892/ijo.5.5.1137