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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 1994 Volume 5 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 1994 Volume 5 Issue 5

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Article

IN-VITRO ANTITUMOR-ACTIVITY OF THE PLANT RIBOSOME-INACTIVATING PROTEINS MAP-30 AND GAP-31

  • Authors:
    • SM RYBAK
    • JJ LIN
    • DL NEWTON
    • HF KUNG
    • A MONKS
    • HC CHEN
    • PL HUANG
    • S LEEHUANG

  • View Affiliations / Copyright

    Affiliations: PROGRAM RESOURCES INC,DYNCORP,BIOL CARCINOGENESIS & DEV PROGRAM,FREDERICK,MD 21702. NICHHD,ENDOCRINOL & REPROD RES BRANCH,BETHESDA,MD 20892. NYU,SCH MED,DEPT BIOCHEM,NEW YORK,NY 10016. AMER BIOSCI,NEW YORK,NY 10021.
  • Pages: 1171-1176
    |
    Published online on: November 1, 1994
       https://doi.org/10.3892/ijo.5.5.1171
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Abstract

MAP 30 and GAP 31 are plant proteins isolated from Momordica charantia and Gelonium multiflorum, respectively. They have recently been shown to inhibit HIV-1 infection and replication. These proteins also possess a novel DNA topoisomerase-poison-like activity as well as ribosome inactivation. They were submitted to the Anti-Cancer Drug Screening Program of the National Cancer Institute and found to have potent anti-tumor activity against certain human tumor cell lines. The most sensitive cell lines responded to MAP 30 and GAP 31 with GI(50) that ranged from 0.01 to 10 mu g/ml and were unrelated to tumor type. These included cell lines from renal, non-small cell lung, and breast cancer. Targeted immunofusions made with MAP 30 or GAP 31 may be most effective toward these types of tumors.

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Copy and paste a formatted citation
Spandidos Publications style
RYBAK S, LIN J, NEWTON D, KUNG H, MONKS A, CHEN H, HUANG P and LEEHUANG S: IN-VITRO ANTITUMOR-ACTIVITY OF THE PLANT RIBOSOME-INACTIVATING PROTEINS MAP-30 AND GAP-31. Int J Oncol 5: 1171-1176, 1994.
APA
RYBAK, S., LIN, J., NEWTON, D., KUNG, H., MONKS, A., CHEN, H. ... LEEHUANG, S. (1994). IN-VITRO ANTITUMOR-ACTIVITY OF THE PLANT RIBOSOME-INACTIVATING PROTEINS MAP-30 AND GAP-31. International Journal of Oncology, 5, 1171-1176. https://doi.org/10.3892/ijo.5.5.1171
MLA
RYBAK, S., LIN, J., NEWTON, D., KUNG, H., MONKS, A., CHEN, H., HUANG, P., LEEHUANG, S."IN-VITRO ANTITUMOR-ACTIVITY OF THE PLANT RIBOSOME-INACTIVATING PROTEINS MAP-30 AND GAP-31". International Journal of Oncology 5.5 (1994): 1171-1176.
Chicago
RYBAK, S., LIN, J., NEWTON, D., KUNG, H., MONKS, A., CHEN, H., HUANG, P., LEEHUANG, S."IN-VITRO ANTITUMOR-ACTIVITY OF THE PLANT RIBOSOME-INACTIVATING PROTEINS MAP-30 AND GAP-31". International Journal of Oncology 5, no. 5 (1994): 1171-1176. https://doi.org/10.3892/ijo.5.5.1171
Copy and paste a formatted citation
x
Spandidos Publications style
RYBAK S, LIN J, NEWTON D, KUNG H, MONKS A, CHEN H, HUANG P and LEEHUANG S: IN-VITRO ANTITUMOR-ACTIVITY OF THE PLANT RIBOSOME-INACTIVATING PROTEINS MAP-30 AND GAP-31. Int J Oncol 5: 1171-1176, 1994.
APA
RYBAK, S., LIN, J., NEWTON, D., KUNG, H., MONKS, A., CHEN, H. ... LEEHUANG, S. (1994). IN-VITRO ANTITUMOR-ACTIVITY OF THE PLANT RIBOSOME-INACTIVATING PROTEINS MAP-30 AND GAP-31. International Journal of Oncology, 5, 1171-1176. https://doi.org/10.3892/ijo.5.5.1171
MLA
RYBAK, S., LIN, J., NEWTON, D., KUNG, H., MONKS, A., CHEN, H., HUANG, P., LEEHUANG, S."IN-VITRO ANTITUMOR-ACTIVITY OF THE PLANT RIBOSOME-INACTIVATING PROTEINS MAP-30 AND GAP-31". International Journal of Oncology 5.5 (1994): 1171-1176.
Chicago
RYBAK, S., LIN, J., NEWTON, D., KUNG, H., MONKS, A., CHEN, H., HUANG, P., LEEHUANG, S."IN-VITRO ANTITUMOR-ACTIVITY OF THE PLANT RIBOSOME-INACTIVATING PROTEINS MAP-30 AND GAP-31". International Journal of Oncology 5, no. 5 (1994): 1171-1176. https://doi.org/10.3892/ijo.5.5.1171
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