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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 1994 Volume 5 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December 1994 Volume 5 Issue 6

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Article

THE ADENOVIRUS E1A-ASSOCIATED P300 PROTEIN IS DIFFERENTIALLY PHOSPHORYLATED IN AD12 E1A-COMPARED TO AD5 E1A-TRANSFORMED RAT-CELLS

  • Authors:
    • DS PEREIRA
    • T JELINEK
    • FL GRAHAM

  • View Affiliations / Copyright

    Affiliations: MCMASTER UNIV,DEPT BIOL,HAMILTON L8S 4K1,ON,CANADA. MCMASTER UNIV,DEPT PATHOL,HAMILTON L8S 4K1,ON,CANADA.
  • Pages: 1197-1205
    |
    Published online on: December 1, 1994
       https://doi.org/10.3892/ijo.5.6.1197
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Abstract

Recently, using hybrid Ad5/12 E1A-transformed rat cells, we identified at least two regions of Ad12 E1A which influence tumorigenicity. In this report, again using the hybrid Ad5/12 E1A-transformants, we show that expression of these same two Ad12 E1A regions not only correlates with down-regulation of cell surface MHC class I expression, but coincides with the presence of an altered form of the E1A-associated cellular protein, p300, detected as a more slowly migrating species in SDS-polyacrylamide gels. The decreased electrophoretic mobility of p300 from hybrid Ad5/12 E1A- and Ad12 E1A-transformants can be abolished by protein phosphatase treatment suggesting that the change in mobility results from differential phosphorylation of p300. We suggest that differential phosphorylation of p300 may be functionally significant in the context of phenotypic differences between Ad5 E1- and Ad12 E1-transformed cells.

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Copy and paste a formatted citation
Spandidos Publications style
PEREIRA D, JELINEK T and GRAHAM F: THE ADENOVIRUS E1A-ASSOCIATED P300 PROTEIN IS DIFFERENTIALLY PHOSPHORYLATED IN AD12 E1A-COMPARED TO AD5 E1A-TRANSFORMED RAT-CELLS. Int J Oncol 5: 1197-1205, 1994.
APA
PEREIRA, D., JELINEK, T., & GRAHAM, F. (1994). THE ADENOVIRUS E1A-ASSOCIATED P300 PROTEIN IS DIFFERENTIALLY PHOSPHORYLATED IN AD12 E1A-COMPARED TO AD5 E1A-TRANSFORMED RAT-CELLS. International Journal of Oncology, 5, 1197-1205. https://doi.org/10.3892/ijo.5.6.1197
MLA
PEREIRA, D., JELINEK, T., GRAHAM, F."THE ADENOVIRUS E1A-ASSOCIATED P300 PROTEIN IS DIFFERENTIALLY PHOSPHORYLATED IN AD12 E1A-COMPARED TO AD5 E1A-TRANSFORMED RAT-CELLS". International Journal of Oncology 5.6 (1994): 1197-1205.
Chicago
PEREIRA, D., JELINEK, T., GRAHAM, F."THE ADENOVIRUS E1A-ASSOCIATED P300 PROTEIN IS DIFFERENTIALLY PHOSPHORYLATED IN AD12 E1A-COMPARED TO AD5 E1A-TRANSFORMED RAT-CELLS". International Journal of Oncology 5, no. 6 (1994): 1197-1205. https://doi.org/10.3892/ijo.5.6.1197
Copy and paste a formatted citation
x
Spandidos Publications style
PEREIRA D, JELINEK T and GRAHAM F: THE ADENOVIRUS E1A-ASSOCIATED P300 PROTEIN IS DIFFERENTIALLY PHOSPHORYLATED IN AD12 E1A-COMPARED TO AD5 E1A-TRANSFORMED RAT-CELLS. Int J Oncol 5: 1197-1205, 1994.
APA
PEREIRA, D., JELINEK, T., & GRAHAM, F. (1994). THE ADENOVIRUS E1A-ASSOCIATED P300 PROTEIN IS DIFFERENTIALLY PHOSPHORYLATED IN AD12 E1A-COMPARED TO AD5 E1A-TRANSFORMED RAT-CELLS. International Journal of Oncology, 5, 1197-1205. https://doi.org/10.3892/ijo.5.6.1197
MLA
PEREIRA, D., JELINEK, T., GRAHAM, F."THE ADENOVIRUS E1A-ASSOCIATED P300 PROTEIN IS DIFFERENTIALLY PHOSPHORYLATED IN AD12 E1A-COMPARED TO AD5 E1A-TRANSFORMED RAT-CELLS". International Journal of Oncology 5.6 (1994): 1197-1205.
Chicago
PEREIRA, D., JELINEK, T., GRAHAM, F."THE ADENOVIRUS E1A-ASSOCIATED P300 PROTEIN IS DIFFERENTIALLY PHOSPHORYLATED IN AD12 E1A-COMPARED TO AD5 E1A-TRANSFORMED RAT-CELLS". International Journal of Oncology 5, no. 6 (1994): 1197-1205. https://doi.org/10.3892/ijo.5.6.1197
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