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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 1994 Volume 5 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 1994 Volume 5 Issue 6

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Article

INDUCTION OF RESISTANCE TO DAUNORUBICIN IN DRUG-SENSITIVE LEUKEMIA P388 CELLS - A ROLE OF PKC-BETA-I ISOZYME

  • Authors:
    • S GOLLAPUDI
    • J DENIEGA
    • V SONI
    • S GUPTA

  • View Affiliations / Copyright

    Affiliations: UNIV CALIF IRVINE,MED SCI 1,DIV BASIC & CLIN IMMUNOL,IRVINE,CA 92717.
  • Pages: 1227-1231
    |
    Published online on: December 1, 1994
       https://doi.org/10.3892/ijo.5.6.1227
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Abstract

A role of protein kinase C (PKC) has been suggested in multidrug resistance (MDR). Because of the molecular and biochemical heterogeneity of PKC, we examined a role of PKC beta isozyme in drug sensitive murine leukemia P388 cell line. Drug sensitive P388 and MDR P388/ADR cells were treated with various concentrations of 12-deoxyphorbol-13-O-phenylacetate 20 acetate (DPPA, an agonist of PKC beta I isozyme) and examined for its effect on daunorubicin (DNR) accumulation and sensitivity to DNR. dPPA increased DNR resistance and decreased DNR accumulation in P388 cells but had no effect in P388/ADR cells. The reduced dPPA-induced DNR accumulation was due to decreased uptake without any effect on DNR efflux. Furthermore, treatment of P388 cells with dPPA was associated with translocation of PKC beta isozyme from cytosol to plasma membrane. These data suggest that PKC beta I isozyme plays a role in acquired drug resistance.

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Copy and paste a formatted citation
Spandidos Publications style
GOLLAPUDI S, DENIEGA J, SONI V and GUPTA S: INDUCTION OF RESISTANCE TO DAUNORUBICIN IN DRUG-SENSITIVE LEUKEMIA P388 CELLS - A ROLE OF PKC-BETA-I ISOZYME. Int J Oncol 5: 1227-1231, 1994.
APA
GOLLAPUDI, S., DENIEGA, J., SONI, V., & GUPTA, S. (1994). INDUCTION OF RESISTANCE TO DAUNORUBICIN IN DRUG-SENSITIVE LEUKEMIA P388 CELLS - A ROLE OF PKC-BETA-I ISOZYME. International Journal of Oncology, 5, 1227-1231. https://doi.org/10.3892/ijo.5.6.1227
MLA
GOLLAPUDI, S., DENIEGA, J., SONI, V., GUPTA, S."INDUCTION OF RESISTANCE TO DAUNORUBICIN IN DRUG-SENSITIVE LEUKEMIA P388 CELLS - A ROLE OF PKC-BETA-I ISOZYME". International Journal of Oncology 5.6 (1994): 1227-1231.
Chicago
GOLLAPUDI, S., DENIEGA, J., SONI, V., GUPTA, S."INDUCTION OF RESISTANCE TO DAUNORUBICIN IN DRUG-SENSITIVE LEUKEMIA P388 CELLS - A ROLE OF PKC-BETA-I ISOZYME". International Journal of Oncology 5, no. 6 (1994): 1227-1231. https://doi.org/10.3892/ijo.5.6.1227
Copy and paste a formatted citation
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Spandidos Publications style
GOLLAPUDI S, DENIEGA J, SONI V and GUPTA S: INDUCTION OF RESISTANCE TO DAUNORUBICIN IN DRUG-SENSITIVE LEUKEMIA P388 CELLS - A ROLE OF PKC-BETA-I ISOZYME. Int J Oncol 5: 1227-1231, 1994.
APA
GOLLAPUDI, S., DENIEGA, J., SONI, V., & GUPTA, S. (1994). INDUCTION OF RESISTANCE TO DAUNORUBICIN IN DRUG-SENSITIVE LEUKEMIA P388 CELLS - A ROLE OF PKC-BETA-I ISOZYME. International Journal of Oncology, 5, 1227-1231. https://doi.org/10.3892/ijo.5.6.1227
MLA
GOLLAPUDI, S., DENIEGA, J., SONI, V., GUPTA, S."INDUCTION OF RESISTANCE TO DAUNORUBICIN IN DRUG-SENSITIVE LEUKEMIA P388 CELLS - A ROLE OF PKC-BETA-I ISOZYME". International Journal of Oncology 5.6 (1994): 1227-1231.
Chicago
GOLLAPUDI, S., DENIEGA, J., SONI, V., GUPTA, S."INDUCTION OF RESISTANCE TO DAUNORUBICIN IN DRUG-SENSITIVE LEUKEMIA P388 CELLS - A ROLE OF PKC-BETA-I ISOZYME". International Journal of Oncology 5, no. 6 (1994): 1227-1231. https://doi.org/10.3892/ijo.5.6.1227
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