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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 1994 Volume 5 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 1994 Volume 5 Issue 6

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Article

INCREASED MDM2 EXPRESSION AND IMMUNOREACTIVITY IN HUMAN PANCREATIC DUCTAL ADENOCARCINOMA

  • Authors:
    • M EBERT
    • M YOKOYAMA
    • MS KOBRIN
    • H FRIESS
    • MW BUCHLER
    • M KORC

  • View Affiliations / Copyright

    Affiliations: UNIV CALIF IRVINE,DEPT MED,DIV ENDOCRINOL & METAB,IRVINE,CA 92717. UNIV CALIF IRVINE,DEPT BIOL CHEM,IRVINE,CA 92717. UNIV BERN,INSELSPITAL,DEPT VISCERAL & TRANSPLANTAT SURG,CH-3010 BERN,SWITZERLAND.
  • Pages: 1279-1284
    |
    Published online on: December 1, 1994
       https://doi.org/10.3892/ijo.5.6.1279
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Abstract

The murine double minute-2 (MDM2) gene encodes a 90 kDa protein which binds and inactivates the protein product of the p53 tumor suppressor gene. To elucidate the potential role of MDM2 in benign and malignant hyperproliferative conditions in the pancreas, we studied MDM2 expression in cultured human pancreatic cancer cells and in pancreatic tissues from normal donors, patients with pancreatic ductal adenocarcinoma and patients with chronic pancreatitis (CP). All the tested cell lines (PANC-1, COLO-357, HPAF and T3M4) expressed a 5.5 kilobase MDM2 mRNA transcript and exhibited nuclear MDM2 immunostaining. MDM2 mRNA levels were comparable in all 18 normal and 14 CP tissues for which RNA samples were available for analysis. By comparison with the normal samples, MDM2 mRNA levels were increased 6.4-fold in 8 of 12 human pancreatic cancer samples (p < 0.0001). All 8 samples exhibited nuclear MDM2 immunostaining, which was also present in 24 of 37 additional pancreatic cancers. Mild MDM2 immunoreactivity was seen in only 1 of 20 CP samples and in none of the 18 normal samples. These findings indicate that MDM2 is overexpressed in a majority of pancreatic adenocarcinomas, but not in CP samples. This selective overexpression raises the possibility that MDM2 may contribute to pancreatic neoplastic transformation by interfering with the growth-suppressing activity of wild-type p53.

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Copy and paste a formatted citation
Spandidos Publications style
EBERT M, YOKOYAMA M, KOBRIN M, FRIESS H, BUCHLER M and KORC M: INCREASED MDM2 EXPRESSION AND IMMUNOREACTIVITY IN HUMAN PANCREATIC DUCTAL ADENOCARCINOMA. Int J Oncol 5: 1279-1284, 1994.
APA
EBERT, M., YOKOYAMA, M., KOBRIN, M., FRIESS, H., BUCHLER, M., & KORC, M. (1994). INCREASED MDM2 EXPRESSION AND IMMUNOREACTIVITY IN HUMAN PANCREATIC DUCTAL ADENOCARCINOMA. International Journal of Oncology, 5, 1279-1284. https://doi.org/10.3892/ijo.5.6.1279
MLA
EBERT, M., YOKOYAMA, M., KOBRIN, M., FRIESS, H., BUCHLER, M., KORC, M."INCREASED MDM2 EXPRESSION AND IMMUNOREACTIVITY IN HUMAN PANCREATIC DUCTAL ADENOCARCINOMA". International Journal of Oncology 5.6 (1994): 1279-1284.
Chicago
EBERT, M., YOKOYAMA, M., KOBRIN, M., FRIESS, H., BUCHLER, M., KORC, M."INCREASED MDM2 EXPRESSION AND IMMUNOREACTIVITY IN HUMAN PANCREATIC DUCTAL ADENOCARCINOMA". International Journal of Oncology 5, no. 6 (1994): 1279-1284. https://doi.org/10.3892/ijo.5.6.1279
Copy and paste a formatted citation
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Spandidos Publications style
EBERT M, YOKOYAMA M, KOBRIN M, FRIESS H, BUCHLER M and KORC M: INCREASED MDM2 EXPRESSION AND IMMUNOREACTIVITY IN HUMAN PANCREATIC DUCTAL ADENOCARCINOMA. Int J Oncol 5: 1279-1284, 1994.
APA
EBERT, M., YOKOYAMA, M., KOBRIN, M., FRIESS, H., BUCHLER, M., & KORC, M. (1994). INCREASED MDM2 EXPRESSION AND IMMUNOREACTIVITY IN HUMAN PANCREATIC DUCTAL ADENOCARCINOMA. International Journal of Oncology, 5, 1279-1284. https://doi.org/10.3892/ijo.5.6.1279
MLA
EBERT, M., YOKOYAMA, M., KOBRIN, M., FRIESS, H., BUCHLER, M., KORC, M."INCREASED MDM2 EXPRESSION AND IMMUNOREACTIVITY IN HUMAN PANCREATIC DUCTAL ADENOCARCINOMA". International Journal of Oncology 5.6 (1994): 1279-1284.
Chicago
EBERT, M., YOKOYAMA, M., KOBRIN, M., FRIESS, H., BUCHLER, M., KORC, M."INCREASED MDM2 EXPRESSION AND IMMUNOREACTIVITY IN HUMAN PANCREATIC DUCTAL ADENOCARCINOMA". International Journal of Oncology 5, no. 6 (1994): 1279-1284. https://doi.org/10.3892/ijo.5.6.1279
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