MULTIDRUG-RESISTANCE GENE (MDR1) EXPRESSION IN HUMAN TUMOR XENOGRAFTS

ABE,Y; NAKAMURA,M; OHNISHI,Y; INABA,M; UEYAMA,Y; TAMAOKA,N

doi:10.3892/ijo.5.6.1285

MULTIDRUG-RESISTANCE GENE (MDR1) EXPRESSION IN HUMAN TUMOR XENOGRAFTS

Authors:
- Y ABE
- M NAKAMURA
- Y OHNISHI
- M INABA
- Y UEYAMA
- N TAMAOKA
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Affiliations: TOKAI UNIV,SCH MED,DEPT PATHOL,ISEHARA,KANAGAWA 25911,JAPAN. CENT INST EXPTL ANIM,KAWASAKI,KANAGAWA 213,JAPAN. JAPANESE FDN CANC RES,CTR CANC CHEMOTHERAPY,TOSHIMA KU,TOKYO 170,JAPAN. KANAGAWA ACAD SCI & TECHNOL,KAWASAKI,KANAGAWA 213,JAPAN.
Published online on: December 1, 1994 https://doi.org/10.3892/ijo.5.6.1285
Pages: 1285-1292

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Abstract

We examined the expression of human multidrug resistance gene (MDR1); 13 of 34 xenografts showed various MDR1 gene transcript levels by reverse transcriptase-polymerase chain reaction. MDR1 was detected in 3 of 10 lung, 5 of 8 gastric, 3 of 3 colon and 2 of 3 pancreatic cancers, but not in 4 breast cancers, or 6 gliomas. We evaluated drug-sensitivity of xenografts in vivo; 28 of 34 xenografts showed drug resistance to vincristine and/or doxorubicin, whereas 13 of 28 drug-resistant xenografts expressed MDR1. The expression of MDR1 may explain the intrinsic drug resistance in certain xenografts.