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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 1994 Volume 5 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December 1994 Volume 5 Issue 6

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Article

MULTIDRUG-RESISTANCE GENE (MDR1) EXPRESSION IN HUMAN TUMOR XENOGRAFTS

  • Authors:
    • Y ABE
    • M NAKAMURA
    • Y OHNISHI
    • M INABA
    • Y UEYAMA
    • N TAMAOKA
  • View Affiliations / Copyright

    Affiliations: TOKAI UNIV,SCH MED,DEPT PATHOL,ISEHARA,KANAGAWA 25911,JAPAN. CENT INST EXPTL ANIM,KAWASAKI,KANAGAWA 213,JAPAN. JAPANESE FDN CANC RES,CTR CANC CHEMOTHERAPY,TOSHIMA KU,TOKYO 170,JAPAN. KANAGAWA ACAD SCI & TECHNOL,KAWASAKI,KANAGAWA 213,JAPAN.
  • Pages: 1285-1292
    |
    Published online on: December 1, 1994
       https://doi.org/10.3892/ijo.5.6.1285
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Abstract

We examined the expression of human multidrug resistance gene (MDR1); 13 of 34 xenografts showed various MDR1 gene transcript levels by reverse transcriptase-polymerase chain reaction. MDR1 was detected in 3 of 10 lung, 5 of 8 gastric, 3 of 3 colon and 2 of 3 pancreatic cancers, but not in 4 breast cancers, or 6 gliomas. We evaluated drug-sensitivity of xenografts in vivo; 28 of 34 xenografts showed drug resistance to vincristine and/or doxorubicin, whereas 13 of 28 drug-resistant xenografts expressed MDR1. The expression of MDR1 may explain the intrinsic drug resistance in certain xenografts.

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Copy and paste a formatted citation
Spandidos Publications style
ABE Y, NAKAMURA M, OHNISHI Y, INABA M, UEYAMA Y and TAMAOKA N: MULTIDRUG-RESISTANCE GENE (MDR1) EXPRESSION IN HUMAN TUMOR XENOGRAFTS. Int J Oncol 5: 1285-1292, 1994.
APA
ABE, Y., NAKAMURA, M., OHNISHI, Y., INABA, M., UEYAMA, Y., & TAMAOKA, N. (1994). MULTIDRUG-RESISTANCE GENE (MDR1) EXPRESSION IN HUMAN TUMOR XENOGRAFTS. International Journal of Oncology, 5, 1285-1292. https://doi.org/10.3892/ijo.5.6.1285
MLA
ABE, Y., NAKAMURA, M., OHNISHI, Y., INABA, M., UEYAMA, Y., TAMAOKA, N."MULTIDRUG-RESISTANCE GENE (MDR1) EXPRESSION IN HUMAN TUMOR XENOGRAFTS". International Journal of Oncology 5.6 (1994): 1285-1292.
Chicago
ABE, Y., NAKAMURA, M., OHNISHI, Y., INABA, M., UEYAMA, Y., TAMAOKA, N."MULTIDRUG-RESISTANCE GENE (MDR1) EXPRESSION IN HUMAN TUMOR XENOGRAFTS". International Journal of Oncology 5, no. 6 (1994): 1285-1292. https://doi.org/10.3892/ijo.5.6.1285
Copy and paste a formatted citation
x
Spandidos Publications style
ABE Y, NAKAMURA M, OHNISHI Y, INABA M, UEYAMA Y and TAMAOKA N: MULTIDRUG-RESISTANCE GENE (MDR1) EXPRESSION IN HUMAN TUMOR XENOGRAFTS. Int J Oncol 5: 1285-1292, 1994.
APA
ABE, Y., NAKAMURA, M., OHNISHI, Y., INABA, M., UEYAMA, Y., & TAMAOKA, N. (1994). MULTIDRUG-RESISTANCE GENE (MDR1) EXPRESSION IN HUMAN TUMOR XENOGRAFTS. International Journal of Oncology, 5, 1285-1292. https://doi.org/10.3892/ijo.5.6.1285
MLA
ABE, Y., NAKAMURA, M., OHNISHI, Y., INABA, M., UEYAMA, Y., TAMAOKA, N."MULTIDRUG-RESISTANCE GENE (MDR1) EXPRESSION IN HUMAN TUMOR XENOGRAFTS". International Journal of Oncology 5.6 (1994): 1285-1292.
Chicago
ABE, Y., NAKAMURA, M., OHNISHI, Y., INABA, M., UEYAMA, Y., TAMAOKA, N."MULTIDRUG-RESISTANCE GENE (MDR1) EXPRESSION IN HUMAN TUMOR XENOGRAFTS". International Journal of Oncology 5, no. 6 (1994): 1285-1292. https://doi.org/10.3892/ijo.5.6.1285
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