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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 1994 Volume 5 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 1994 Volume 5 Issue 6

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Article

FILTERED, TAR-FREE AND AEROSOL-FREE CIGARETTE-SMOKE CAUSES ACCUMULATION OF THE TUMOR-SUPPRESSOR PROTEIN P53 IN RODENT CELLS

  • Authors:
    • A SCHULZE-LUTUM
    • J SIEGEL
    • RJ SCHMIDT
    • B PLAUMANN
    • C BRAUN
    • C HAESSLER
    • G BRANDNER
    • RD HESS

  • View Affiliations / Copyright

    Affiliations: UNIV FREIBURG, INST MED MIKROBIOL & HYG, VIROL ABT, W-7900 FREIBURG, GERMANY.
  • Pages: 1405-1409
    |
    Published online on: December 1, 1994
       https://doi.org/10.3892/ijo.5.6.1405
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Abstract

Cigarette smoke was filtered with a Cambridge glass fiber filter retaining 99.9% of the tar and aerosol fraction and diluted 1:5 with air. The murine cell line L929 was exposed to this smoke preparation for periods of up to 10 min. Thereafter the following parameters were determined at different times: Nuclear accumulation of the tumor suppressor protein p53 indicating chromatin injury (by immunostaining); apoptotic DNA fragmentation (by DNA end labelling with biotin-16-dUTP in the presence of terminal deoxyribonucleotidyl transferase); the intracellular level of reactive oxygen intermediates (ROI) (by cytofluorimetry with the fluorigenic stain 2',7'-dichlorofluorescin diacetate). After 1 min exposure to 1:5 air-diluted filtered cigarette smoke maximal p53 accumulation occured about 20 h later, whereas maximal DNA fragmentation and apoptosis and maximal ROI levels were found after 10 min of exposure. Obviously, even the diluted, tar- and aerosol-free fraction of cigarette smoke has the potency, after 1 min of exposure only, to exert severe DNA damage, a potential transformation risk for the surviving cell fraction, in murine cell cultures as indicated by stabilization and accumulation of the tumor suppressor protein p53.

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Copy and paste a formatted citation
Spandidos Publications style
SCHULZE-LUTUM A, SIEGEL J, SCHMIDT R, PLAUMANN B, BRAUN C, HAESSLER C, BRANDNER G and HESS R: FILTERED, TAR-FREE AND AEROSOL-FREE CIGARETTE-SMOKE CAUSES ACCUMULATION OF THE TUMOR-SUPPRESSOR PROTEIN P53 IN RODENT CELLS. Int J Oncol 5: 1405-1409, 1994.
APA
SCHULZE-LUTUM, A., SIEGEL, J., SCHMIDT, R., PLAUMANN, B., BRAUN, C., HAESSLER, C. ... HESS, R. (1994). FILTERED, TAR-FREE AND AEROSOL-FREE CIGARETTE-SMOKE CAUSES ACCUMULATION OF THE TUMOR-SUPPRESSOR PROTEIN P53 IN RODENT CELLS. International Journal of Oncology, 5, 1405-1409. https://doi.org/10.3892/ijo.5.6.1405
MLA
SCHULZE-LUTUM, A., SIEGEL, J., SCHMIDT, R., PLAUMANN, B., BRAUN, C., HAESSLER, C., BRANDNER, G., HESS, R."FILTERED, TAR-FREE AND AEROSOL-FREE CIGARETTE-SMOKE CAUSES ACCUMULATION OF THE TUMOR-SUPPRESSOR PROTEIN P53 IN RODENT CELLS". International Journal of Oncology 5.6 (1994): 1405-1409.
Chicago
SCHULZE-LUTUM, A., SIEGEL, J., SCHMIDT, R., PLAUMANN, B., BRAUN, C., HAESSLER, C., BRANDNER, G., HESS, R."FILTERED, TAR-FREE AND AEROSOL-FREE CIGARETTE-SMOKE CAUSES ACCUMULATION OF THE TUMOR-SUPPRESSOR PROTEIN P53 IN RODENT CELLS". International Journal of Oncology 5, no. 6 (1994): 1405-1409. https://doi.org/10.3892/ijo.5.6.1405
Copy and paste a formatted citation
x
Spandidos Publications style
SCHULZE-LUTUM A, SIEGEL J, SCHMIDT R, PLAUMANN B, BRAUN C, HAESSLER C, BRANDNER G and HESS R: FILTERED, TAR-FREE AND AEROSOL-FREE CIGARETTE-SMOKE CAUSES ACCUMULATION OF THE TUMOR-SUPPRESSOR PROTEIN P53 IN RODENT CELLS. Int J Oncol 5: 1405-1409, 1994.
APA
SCHULZE-LUTUM, A., SIEGEL, J., SCHMIDT, R., PLAUMANN, B., BRAUN, C., HAESSLER, C. ... HESS, R. (1994). FILTERED, TAR-FREE AND AEROSOL-FREE CIGARETTE-SMOKE CAUSES ACCUMULATION OF THE TUMOR-SUPPRESSOR PROTEIN P53 IN RODENT CELLS. International Journal of Oncology, 5, 1405-1409. https://doi.org/10.3892/ijo.5.6.1405
MLA
SCHULZE-LUTUM, A., SIEGEL, J., SCHMIDT, R., PLAUMANN, B., BRAUN, C., HAESSLER, C., BRANDNER, G., HESS, R."FILTERED, TAR-FREE AND AEROSOL-FREE CIGARETTE-SMOKE CAUSES ACCUMULATION OF THE TUMOR-SUPPRESSOR PROTEIN P53 IN RODENT CELLS". International Journal of Oncology 5.6 (1994): 1405-1409.
Chicago
SCHULZE-LUTUM, A., SIEGEL, J., SCHMIDT, R., PLAUMANN, B., BRAUN, C., HAESSLER, C., BRANDNER, G., HESS, R."FILTERED, TAR-FREE AND AEROSOL-FREE CIGARETTE-SMOKE CAUSES ACCUMULATION OF THE TUMOR-SUPPRESSOR PROTEIN P53 IN RODENT CELLS". International Journal of Oncology 5, no. 6 (1994): 1405-1409. https://doi.org/10.3892/ijo.5.6.1405
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