HUMAN BREAST-CARCINOMA CELLS SHOW CORRELATION IN EXPRESSION OF C-MYC ONCOGENE AND THE C-MYC BINDING-PROTEIN (MBP-1)

  • Authors:
    • RB RAY
    • SM SHEIKH
    • JA FONTANA
    • DM MILLER
  • View Affiliations

  • Published online on: December 1, 1994     https://doi.org/10.3892/ijo.5.6.1433
  • Pages: 1433-1436
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Abstract

The c-myc proto-oncogene is an early response gene which plays an important role in regulation of cell proliferation, differentiation and cell cycle control. Amplification and/or overexpression of this gene occurs in human breast carcinoma eels. The human c-myc promoter binding protein (MBP-1) is a negative regulatory factor for c-myc transcription, which binds to the upstream region of the c-myc P2 promoter. It was cloned and characterized from human cervical carcinoma cells. Normal human tissues and human breast carcinoma cells showed an elevated level of both MBP-1 and c-myc gene expression. In estrogen receptor (ER)-negative cells, the level of MBP-1 expression was higher than that of ER-positive cells. These results suggested a correlation between estrogen receptor status and the MBP-1 mRNA level.

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December 1994
Volume 5 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
RAY R, SHEIKH S, FONTANA J and MILLER D: HUMAN BREAST-CARCINOMA CELLS SHOW CORRELATION IN EXPRESSION OF C-MYC ONCOGENE AND THE C-MYC BINDING-PROTEIN (MBP-1). Int J Oncol 5: 1433-1436, 1994.
APA
RAY, R., SHEIKH, S., FONTANA, J., & MILLER, D. (1994). HUMAN BREAST-CARCINOMA CELLS SHOW CORRELATION IN EXPRESSION OF C-MYC ONCOGENE AND THE C-MYC BINDING-PROTEIN (MBP-1). International Journal of Oncology, 5, 1433-1436. https://doi.org/10.3892/ijo.5.6.1433
MLA
RAY, R., SHEIKH, S., FONTANA, J., MILLER, D."HUMAN BREAST-CARCINOMA CELLS SHOW CORRELATION IN EXPRESSION OF C-MYC ONCOGENE AND THE C-MYC BINDING-PROTEIN (MBP-1)". International Journal of Oncology 5.6 (1994): 1433-1436.
Chicago
RAY, R., SHEIKH, S., FONTANA, J., MILLER, D."HUMAN BREAST-CARCINOMA CELLS SHOW CORRELATION IN EXPRESSION OF C-MYC ONCOGENE AND THE C-MYC BINDING-PROTEIN (MBP-1)". International Journal of Oncology 5, no. 6 (1994): 1433-1436. https://doi.org/10.3892/ijo.5.6.1433