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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 1995 Volume 6 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 1995 Volume 6 Issue 1

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Article

EVALUATION OF PROGNOSTIC-SIGNIFICANCE OF P53 GENE ALTERATIONS IN PATIENTS WITH SURGICALLY RESECTED LUNG-CANCER

  • Authors:
    • T KASHII
    • Y MIZUSHIMA
    • CEQ LIMA
    • H NOTO
    • H SATO
    • H SAITO
    • Y KUSAJIMA
    • M KITAGAWA
    • S SUGIYAMA
    • M KOBAYASHI

  • View Affiliations / Copyright

    Affiliations: TOYAMA MED & PHARMACEUT UNIV,DEPT INTERNAL MED 1,TOYAMA 93001,JAPAN. TOYAMA MED & PHARMACEUT UNIV,DEPT PATHOL 1,TOYAMA 93001,JAPAN. TOYAMA MED & PHARMACEUT UNIV,DEPT SURG 1,TOYAMA 93001,JAPAN. TOYAMA PREFECTURAL CENT HOSP,DEPT CHEST & CARDIOVASC SURG,TOYAMA 930,JAPAN. ISHIKAWA PREFECTURAL CENT HOSP,DEPT THORAC SURG,KANAZAWA,ISHIKAWA 920,JAPAN. KOSEIREN TAKAOKA HOSP,DEPT SURG,TAKAOKA,TOYAMA 933,JAPAN. TOYAMA CITY HOSP,DEPT CHEST SURG,TOYAMA 939,JAPAN.
  • Pages: 123-128
    |
    Published online on: January 1, 1995
       https://doi.org/10.3892/ijo.6.1.123
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Abstract

Clinical significance of p53 gene alterations, as a prognostic factor, was assessed in 69 patients with surgically resected lung cancer. The p53 gene alterations (exon 5-9) were examined by the polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) method of genomic DNA. The p53 gene alterations were detected in all histological types of lung cancer, with a positive rate of 45% (31/69). In the alteration-positive group, patients in the advanced stages of III and IV were seen more frequently than in the negative group (58% vs. 21%, p<0.05). Such a difference was not observed in other parameters such as age, gender, histological type and smoking habit. The prognosis was, on a whole, poorer in the alteration-positive group than for the -negative one (5-year survival rate: 19.3% vs. 40.6%, MST: 17 months vs. 36 months), but the difference did not reach statistical significance. However, in the case of females (p<0.05), adenocarcinoma (p<0.01), early stages of I and II (p<0.05) and non-smokers (p<0.005), a significantly poorer prognosis was observed in the gene alteration-positive group than for the -negative one. These results suggest that the p53 gene alteration may be a useful prognostic factor in certain subgroups with lung resected for cancer.

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Copy and paste a formatted citation
Spandidos Publications style
KASHII T, MIZUSHIMA Y, LIMA C, NOTO H, SATO H, SAITO H, KUSAJIMA Y, KITAGAWA M, SUGIYAMA S, KOBAYASHI M, KOBAYASHI M, et al: EVALUATION OF PROGNOSTIC-SIGNIFICANCE OF P53 GENE ALTERATIONS IN PATIENTS WITH SURGICALLY RESECTED LUNG-CANCER. Int J Oncol 6: 123-128, 1995.
APA
KASHII, T., MIZUSHIMA, Y., LIMA, C., NOTO, H., SATO, H., SAITO, H. ... KOBAYASHI, M. (1995). EVALUATION OF PROGNOSTIC-SIGNIFICANCE OF P53 GENE ALTERATIONS IN PATIENTS WITH SURGICALLY RESECTED LUNG-CANCER. International Journal of Oncology, 6, 123-128. https://doi.org/10.3892/ijo.6.1.123
MLA
KASHII, T., MIZUSHIMA, Y., LIMA, C., NOTO, H., SATO, H., SAITO, H., KUSAJIMA, Y., KITAGAWA, M., SUGIYAMA, S., KOBAYASHI, M."EVALUATION OF PROGNOSTIC-SIGNIFICANCE OF P53 GENE ALTERATIONS IN PATIENTS WITH SURGICALLY RESECTED LUNG-CANCER". International Journal of Oncology 6.1 (1995): 123-128.
Chicago
KASHII, T., MIZUSHIMA, Y., LIMA, C., NOTO, H., SATO, H., SAITO, H., KUSAJIMA, Y., KITAGAWA, M., SUGIYAMA, S., KOBAYASHI, M."EVALUATION OF PROGNOSTIC-SIGNIFICANCE OF P53 GENE ALTERATIONS IN PATIENTS WITH SURGICALLY RESECTED LUNG-CANCER". International Journal of Oncology 6, no. 1 (1995): 123-128. https://doi.org/10.3892/ijo.6.1.123
Copy and paste a formatted citation
x
Spandidos Publications style
KASHII T, MIZUSHIMA Y, LIMA C, NOTO H, SATO H, SAITO H, KUSAJIMA Y, KITAGAWA M, SUGIYAMA S, KOBAYASHI M, KOBAYASHI M, et al: EVALUATION OF PROGNOSTIC-SIGNIFICANCE OF P53 GENE ALTERATIONS IN PATIENTS WITH SURGICALLY RESECTED LUNG-CANCER. Int J Oncol 6: 123-128, 1995.
APA
KASHII, T., MIZUSHIMA, Y., LIMA, C., NOTO, H., SATO, H., SAITO, H. ... KOBAYASHI, M. (1995). EVALUATION OF PROGNOSTIC-SIGNIFICANCE OF P53 GENE ALTERATIONS IN PATIENTS WITH SURGICALLY RESECTED LUNG-CANCER. International Journal of Oncology, 6, 123-128. https://doi.org/10.3892/ijo.6.1.123
MLA
KASHII, T., MIZUSHIMA, Y., LIMA, C., NOTO, H., SATO, H., SAITO, H., KUSAJIMA, Y., KITAGAWA, M., SUGIYAMA, S., KOBAYASHI, M."EVALUATION OF PROGNOSTIC-SIGNIFICANCE OF P53 GENE ALTERATIONS IN PATIENTS WITH SURGICALLY RESECTED LUNG-CANCER". International Journal of Oncology 6.1 (1995): 123-128.
Chicago
KASHII, T., MIZUSHIMA, Y., LIMA, C., NOTO, H., SATO, H., SAITO, H., KUSAJIMA, Y., KITAGAWA, M., SUGIYAMA, S., KOBAYASHI, M."EVALUATION OF PROGNOSTIC-SIGNIFICANCE OF P53 GENE ALTERATIONS IN PATIENTS WITH SURGICALLY RESECTED LUNG-CANCER". International Journal of Oncology 6, no. 1 (1995): 123-128. https://doi.org/10.3892/ijo.6.1.123
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