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PRECLINICAL STUDIES OF GOSSYPOL IN PROSTATE CARCINOMA

  • Authors:
    • HR NAIK
    • D PETRYLAK
    • A YAGODA
    • JE LEHR
    • A AKHTAR
    • KJ PIENTA

  • View Affiliations

  • Published online on: January 1, 1995     https://doi.org/10.3892/ijo.6.1.209
  • Pages: 209-213
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Hormone refractory prostate cancer remains an incurable disease and the discovery of newer agents with higher cytotoxic activity is required. Gossypol is a phenolic compound isolated from cottonseed oil which has been shown to have anti-spermatogenic effects. In in vitro studies, gossypol appears to inhibit the growth of rat prostate cancer cell line MAT-LyLu and human prostate adenocarcinoma cell lines PC-3, LNCaP and DU-145. In vive, gossypol appeared to inhibit tumor growth of subcutaneously implanted MAT-LyLu cells in Copenhagen rats. Gossypol may be an active agent for the treatment of hormone refractory metastatic prostate cancer.

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Journal Cover

January 1995
Volume 6 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 5.2
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 11.4
  • CiteScore Rank: Q1: #40/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 1.125
  • SCImago Journal Rank (SJR): 1.105
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Spandidos Publications style
NAIK H, PETRYLAK D, YAGODA A, LEHR J, AKHTAR A and PIENTA K: PRECLINICAL STUDIES OF GOSSYPOL IN PROSTATE CARCINOMA. Int J Oncol 6: 209-213, 1995
APA
NAIK, H., PETRYLAK, D., YAGODA, A., LEHR, J., AKHTAR, A., & PIENTA, K. (1995). PRECLINICAL STUDIES OF GOSSYPOL IN PROSTATE CARCINOMA. International Journal of Oncology, 6, 209-213. https://doi.org/10.3892/ijo.6.1.209
MLA
NAIK, H., PETRYLAK, D., YAGODA, A., LEHR, J., AKHTAR, A., PIENTA, K."PRECLINICAL STUDIES OF GOSSYPOL IN PROSTATE CARCINOMA". International Journal of Oncology 6.1 (1995): 209-213.
Chicago
NAIK, H., PETRYLAK, D., YAGODA, A., LEHR, J., AKHTAR, A., PIENTA, K."PRECLINICAL STUDIES OF GOSSYPOL IN PROSTATE CARCINOMA". International Journal of Oncology 6, no. 1 (1995): 209-213. https://doi.org/10.3892/ijo.6.1.209