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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 1995 Volume 6 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January 1995 Volume 6 Issue 1

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THE V-ERBA ONCOGENE - A SUPERB TOOL FOR DISSECTING THE INVOLVEMENT OF NUCLEAR HORMONE RECEPTORS IN DIFFERENTIATION AND NEOPLASIA (REVIEW)

  • Authors:
    • O GANDRILLON
    • A RASCLE
    • J SAMARUT

  • View Affiliations / Copyright

    Affiliations: Affliations not specified
  • Pages: 215-231
    |
    Published online on: January 1, 1995
       https://doi.org/10.3892/ijo.6.1.215
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Abstract

The v-erbA oncogene has been discovered as one of the two viral oncogenes carried by the avian leukemia retrovirus AEV. It is derived from the c-erbA protooncogene which encodes the alpha form of the nuclear receptor for the thyroid hormone triiodothyronine (T3R). This receptor belongs to a large family of nuclear hormone receptors that function as ligand-regulated transcription factors and the v-erbA oncoprotein has been shown to function as an antagonist of normal T3R and related receptors in the control of transcription. It is thus the first dominant negative transcription factor acting as an oncogene described to date. Functional and biochemical dissections of this oncogene have brought many informations on the mechanisms of action of normal receptors and on the ways through which altered receptors can contribute to oncogenic transformation. The v-erbA model is widely used as a reference to investigate the involvement of nuclear hormone receptors in the development of human cancers.

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Copy and paste a formatted citation
Spandidos Publications style
GANDRILLON O, RASCLE A and SAMARUT J: THE V-ERBA ONCOGENE - A SUPERB TOOL FOR DISSECTING THE INVOLVEMENT OF NUCLEAR HORMONE RECEPTORS IN DIFFERENTIATION AND NEOPLASIA (REVIEW). Int J Oncol 6: 215-231, 1995.
APA
GANDRILLON, O., RASCLE, A., & SAMARUT, J. (1995). THE V-ERBA ONCOGENE - A SUPERB TOOL FOR DISSECTING THE INVOLVEMENT OF NUCLEAR HORMONE RECEPTORS IN DIFFERENTIATION AND NEOPLASIA (REVIEW). International Journal of Oncology, 6, 215-231. https://doi.org/10.3892/ijo.6.1.215
MLA
GANDRILLON, O., RASCLE, A., SAMARUT, J."THE V-ERBA ONCOGENE - A SUPERB TOOL FOR DISSECTING THE INVOLVEMENT OF NUCLEAR HORMONE RECEPTORS IN DIFFERENTIATION AND NEOPLASIA (REVIEW)". International Journal of Oncology 6.1 (1995): 215-231.
Chicago
GANDRILLON, O., RASCLE, A., SAMARUT, J."THE V-ERBA ONCOGENE - A SUPERB TOOL FOR DISSECTING THE INVOLVEMENT OF NUCLEAR HORMONE RECEPTORS IN DIFFERENTIATION AND NEOPLASIA (REVIEW)". International Journal of Oncology 6, no. 1 (1995): 215-231. https://doi.org/10.3892/ijo.6.1.215
Copy and paste a formatted citation
x
Spandidos Publications style
GANDRILLON O, RASCLE A and SAMARUT J: THE V-ERBA ONCOGENE - A SUPERB TOOL FOR DISSECTING THE INVOLVEMENT OF NUCLEAR HORMONE RECEPTORS IN DIFFERENTIATION AND NEOPLASIA (REVIEW). Int J Oncol 6: 215-231, 1995.
APA
GANDRILLON, O., RASCLE, A., & SAMARUT, J. (1995). THE V-ERBA ONCOGENE - A SUPERB TOOL FOR DISSECTING THE INVOLVEMENT OF NUCLEAR HORMONE RECEPTORS IN DIFFERENTIATION AND NEOPLASIA (REVIEW). International Journal of Oncology, 6, 215-231. https://doi.org/10.3892/ijo.6.1.215
MLA
GANDRILLON, O., RASCLE, A., SAMARUT, J."THE V-ERBA ONCOGENE - A SUPERB TOOL FOR DISSECTING THE INVOLVEMENT OF NUCLEAR HORMONE RECEPTORS IN DIFFERENTIATION AND NEOPLASIA (REVIEW)". International Journal of Oncology 6.1 (1995): 215-231.
Chicago
GANDRILLON, O., RASCLE, A., SAMARUT, J."THE V-ERBA ONCOGENE - A SUPERB TOOL FOR DISSECTING THE INVOLVEMENT OF NUCLEAR HORMONE RECEPTORS IN DIFFERENTIATION AND NEOPLASIA (REVIEW)". International Journal of Oncology 6, no. 1 (1995): 215-231. https://doi.org/10.3892/ijo.6.1.215
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