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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 1995 Volume 6 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 1995 Volume 6 Issue 1

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Article

RFLP ANALYSIS OF THE L-MYC ONCOGENE IN HEAD AND NECK-CANCER - RELATIONSHIP STUDY WITH SUSCEPTIBILITY AND DISEASE PROGRESSION

  • Authors:
    • R MILLON
    • D MULLER
    • M VELTEN
    • S DOFFOEL
    • M EBER
    • A ENGELMANN
    • G BRONNER
    • H FLESCH
    • G METHLIN
    • J ABECASSIS

  • View Affiliations / Copyright

    Affiliations: MGEN,CTR MED NATL DIAGNOST & SOINS,F-67000 STRASBOURG,FRANCE. CLIN ST BARBE,F-67000 STRASBOURG,FRANCE. LAB ANAT PATHOL & NEUROPATHOL,F-67000 STRASBOURG,FRANCE.
  • Pages: 237-242
    |
    Published online on: January 1, 1995
       https://doi.org/10.3892/ijo.6.1.237
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Abstract

The L-myc DNA restriction fragment length polymorphism (RFLF), revealed by EcoRI digestion, has been evaluated in a case-control study including 161 head and neck cancer (HNSCC) patients and 160 normal healthy individuals with similar smoking and alcohol habits. No significant difference in the distribution of L-myc genotypes (LL, LS or SS) was found between the two populations implying thus no predisposition to head and neck tumour by either allele. There was no significant association between L-myc genotypes and the usual clinicopathological features such as T staging, differentiation status and lymph node involvement. Moreover, follow-up data from 154 patients was obtained and correlated with the L-myc pattern. No significant difference was observed in metastasis occurrence, multiple cancer incidence and survival data in the patients classified according to the L-myc genotypes; only a trend to preferentially develop metastasis in lung for patients with S allele was noted. In conclusion, our data shows that the L-myc typing does not contribute to HNSCC risk or prognosis assessment. A review of L-myc RFLP published studies shows contradictory results even on the same type of tumour and emphasizes the lacunae in understanding the biological role of L-myc for valid interpretation of L-myc allelic associations with cancer susceptibility or prognosis.

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Copy and paste a formatted citation
Spandidos Publications style
MILLON R, MULLER D, VELTEN M, DOFFOEL S, EBER M, ENGELMANN A, BRONNER G, FLESCH H, METHLIN G, ABECASSIS J, ABECASSIS J, et al: RFLP ANALYSIS OF THE L-MYC ONCOGENE IN HEAD AND NECK-CANCER - RELATIONSHIP STUDY WITH SUSCEPTIBILITY AND DISEASE PROGRESSION. Int J Oncol 6: 237-242, 1995.
APA
MILLON, R., MULLER, D., VELTEN, M., DOFFOEL, S., EBER, M., ENGELMANN, A. ... ABECASSIS, J. (1995). RFLP ANALYSIS OF THE L-MYC ONCOGENE IN HEAD AND NECK-CANCER - RELATIONSHIP STUDY WITH SUSCEPTIBILITY AND DISEASE PROGRESSION. International Journal of Oncology, 6, 237-242. https://doi.org/10.3892/ijo.6.1.237
MLA
MILLON, R., MULLER, D., VELTEN, M., DOFFOEL, S., EBER, M., ENGELMANN, A., BRONNER, G., FLESCH, H., METHLIN, G., ABECASSIS, J."RFLP ANALYSIS OF THE L-MYC ONCOGENE IN HEAD AND NECK-CANCER - RELATIONSHIP STUDY WITH SUSCEPTIBILITY AND DISEASE PROGRESSION". International Journal of Oncology 6.1 (1995): 237-242.
Chicago
MILLON, R., MULLER, D., VELTEN, M., DOFFOEL, S., EBER, M., ENGELMANN, A., BRONNER, G., FLESCH, H., METHLIN, G., ABECASSIS, J."RFLP ANALYSIS OF THE L-MYC ONCOGENE IN HEAD AND NECK-CANCER - RELATIONSHIP STUDY WITH SUSCEPTIBILITY AND DISEASE PROGRESSION". International Journal of Oncology 6, no. 1 (1995): 237-242. https://doi.org/10.3892/ijo.6.1.237
Copy and paste a formatted citation
x
Spandidos Publications style
MILLON R, MULLER D, VELTEN M, DOFFOEL S, EBER M, ENGELMANN A, BRONNER G, FLESCH H, METHLIN G, ABECASSIS J, ABECASSIS J, et al: RFLP ANALYSIS OF THE L-MYC ONCOGENE IN HEAD AND NECK-CANCER - RELATIONSHIP STUDY WITH SUSCEPTIBILITY AND DISEASE PROGRESSION. Int J Oncol 6: 237-242, 1995.
APA
MILLON, R., MULLER, D., VELTEN, M., DOFFOEL, S., EBER, M., ENGELMANN, A. ... ABECASSIS, J. (1995). RFLP ANALYSIS OF THE L-MYC ONCOGENE IN HEAD AND NECK-CANCER - RELATIONSHIP STUDY WITH SUSCEPTIBILITY AND DISEASE PROGRESSION. International Journal of Oncology, 6, 237-242. https://doi.org/10.3892/ijo.6.1.237
MLA
MILLON, R., MULLER, D., VELTEN, M., DOFFOEL, S., EBER, M., ENGELMANN, A., BRONNER, G., FLESCH, H., METHLIN, G., ABECASSIS, J."RFLP ANALYSIS OF THE L-MYC ONCOGENE IN HEAD AND NECK-CANCER - RELATIONSHIP STUDY WITH SUSCEPTIBILITY AND DISEASE PROGRESSION". International Journal of Oncology 6.1 (1995): 237-242.
Chicago
MILLON, R., MULLER, D., VELTEN, M., DOFFOEL, S., EBER, M., ENGELMANN, A., BRONNER, G., FLESCH, H., METHLIN, G., ABECASSIS, J."RFLP ANALYSIS OF THE L-MYC ONCOGENE IN HEAD AND NECK-CANCER - RELATIONSHIP STUDY WITH SUSCEPTIBILITY AND DISEASE PROGRESSION". International Journal of Oncology 6, no. 1 (1995): 237-242. https://doi.org/10.3892/ijo.6.1.237
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