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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 1995 Volume 6 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 1995 Volume 6 Issue 1

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Article

HUMAN ONCOPROTEIN MDM2 INTERACTS WITH THE TATA-BINDING PROTEIN IN-VITRO AND IN-VIVO

  • Authors:
    • P LENG
    • DR BROWN
    • S DEB
    • SP DEB

  • View Affiliations / Copyright

    Affiliations: UNIV TEXAS,HLTH SCI CTR,DEPT MICROBIOL,SAN ANTONIO,TX 78284.
  • Pages: 251-259
    |
    Published online on: January 1, 1995
       https://doi.org/10.3892/ijo.6.1.251
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Abstract

Human oncoprotein MDM2 inhibits p53-induced transcriptional activation of promoters containing p53-binding sites. In this report we show that MDM2 interacts with the human TATA binding protein (TBP), in vivo and in. vitro, in the absence of p53. The C-terminal boundary of the TBP-binding domain on MDM2 resides between amino acids 221 and 276, whereas the N-terminal boundary is beyond amino acid 120. Thus, the acidic domain of MDM2 overlaps with the TBP binding domain and is needed for the interaction. The C-terminal conserved domain of TBP is required for MDM2 binding. MDM2-TBP interaction suggests a p53-independent, transcription regulatory role of MDM2.

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Copy and paste a formatted citation
Spandidos Publications style
LENG P, BROWN D, DEB S and DEB S: HUMAN ONCOPROTEIN MDM2 INTERACTS WITH THE TATA-BINDING PROTEIN IN-VITRO AND IN-VIVO. Int J Oncol 6: 251-259, 1995.
APA
LENG, P., BROWN, D., DEB, S., & DEB, S. (1995). HUMAN ONCOPROTEIN MDM2 INTERACTS WITH THE TATA-BINDING PROTEIN IN-VITRO AND IN-VIVO. International Journal of Oncology, 6, 251-259. https://doi.org/10.3892/ijo.6.1.251
MLA
LENG, P., BROWN, D., DEB, S., DEB, S."HUMAN ONCOPROTEIN MDM2 INTERACTS WITH THE TATA-BINDING PROTEIN IN-VITRO AND IN-VIVO". International Journal of Oncology 6.1 (1995): 251-259.
Chicago
LENG, P., BROWN, D., DEB, S., DEB, S."HUMAN ONCOPROTEIN MDM2 INTERACTS WITH THE TATA-BINDING PROTEIN IN-VITRO AND IN-VIVO". International Journal of Oncology 6, no. 1 (1995): 251-259. https://doi.org/10.3892/ijo.6.1.251
Copy and paste a formatted citation
x
Spandidos Publications style
LENG P, BROWN D, DEB S and DEB S: HUMAN ONCOPROTEIN MDM2 INTERACTS WITH THE TATA-BINDING PROTEIN IN-VITRO AND IN-VIVO. Int J Oncol 6: 251-259, 1995.
APA
LENG, P., BROWN, D., DEB, S., & DEB, S. (1995). HUMAN ONCOPROTEIN MDM2 INTERACTS WITH THE TATA-BINDING PROTEIN IN-VITRO AND IN-VIVO. International Journal of Oncology, 6, 251-259. https://doi.org/10.3892/ijo.6.1.251
MLA
LENG, P., BROWN, D., DEB, S., DEB, S."HUMAN ONCOPROTEIN MDM2 INTERACTS WITH THE TATA-BINDING PROTEIN IN-VITRO AND IN-VIVO". International Journal of Oncology 6.1 (1995): 251-259.
Chicago
LENG, P., BROWN, D., DEB, S., DEB, S."HUMAN ONCOPROTEIN MDM2 INTERACTS WITH THE TATA-BINDING PROTEIN IN-VITRO AND IN-VIVO". International Journal of Oncology 6, no. 1 (1995): 251-259. https://doi.org/10.3892/ijo.6.1.251
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