EFFECT OF PROTEIN-INTAKE ON TUMOR-GROWTH AND HOST SURVIVAL IN TUMOR-BEARING ANIMALS

  • Authors:
    • MH TOROSIAN
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  • Published online on: January 1, 1995     https://doi.org/10.3892/ijo.6.1.261
  • Pages: 261-264
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Abstract

Nutritional repletion of the tumor-bearing host remains controversial. The present study was performed to determine the effect of protein intake on tumor growth and host survival in tumor-bearing animals. Forty-three female C2H mice with subcutaneous mammary tumor implants (MA 16/C) were randomized to receive standard protein diet or an isocaloric, protein-depleted diet ad libitum per os. Body weight and tumor volume were measured throughout the study and ail animals were maintained on these diets until death. Body weight was significantly greater in animals receiving standard protein intake compared to those given the protein-depleted diet. However, tumor growth was significantly stimulated and host survival reduced in animals given standard protein diet compared to animals maintained on protein-depleted diet. Thus, exogenous protein intake preferentially benefitted tumor versus host anabolism in this animal model with significant reduction in host survival.

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January 1995
Volume 6 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
TOROSIAN M: EFFECT OF PROTEIN-INTAKE ON TUMOR-GROWTH AND HOST SURVIVAL IN TUMOR-BEARING ANIMALS. Int J Oncol 6: 261-264, 1995
APA
TOROSIAN, M. (1995). EFFECT OF PROTEIN-INTAKE ON TUMOR-GROWTH AND HOST SURVIVAL IN TUMOR-BEARING ANIMALS. International Journal of Oncology, 6, 261-264. https://doi.org/10.3892/ijo.6.1.261
MLA
TOROSIAN, M."EFFECT OF PROTEIN-INTAKE ON TUMOR-GROWTH AND HOST SURVIVAL IN TUMOR-BEARING ANIMALS". International Journal of Oncology 6.1 (1995): 261-264.
Chicago
TOROSIAN, M."EFFECT OF PROTEIN-INTAKE ON TUMOR-GROWTH AND HOST SURVIVAL IN TUMOR-BEARING ANIMALS". International Journal of Oncology 6, no. 1 (1995): 261-264. https://doi.org/10.3892/ijo.6.1.261