ANTITUMORAL ACTIVITY OF FLAVONE L-86-8275

  • Authors:
    • J CZECH
    • D HOFFMANN
    • R NAIK
    • HH SEDLACEK
  • View Affiliations

  • Published online on: January 1, 1995     https://doi.org/10.3892/ijo.6.1.31
  • Pages: 31-36
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

L 86-8275, a flavone of novel structure, was shown to be a kinase inhibitor and to possess surprising potent antiproliferative potency (IC50=0.1-0.15 mu M) on various tumor cell lines after long period of incubation. Short period of incubation was significantly less effective (IC50=133 mu M). In vitro L 86-8275 showed almost no cross-resistance on L 1210 mouse leukemia tumor cell line 110-fold resistant to doxorubicin. In vivo significant antitumoral effects were seen with xenografted lung, colon, mammary and ovarian tumors as well as glioblastoma. T/C values ranged from 29 to 86% and were comparable to standard chemotherapeutic treatment. Optimal schedule required daily oral application of L 86-8275.

Related Articles

Journal Cover

January 1995
Volume 6 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
CZECH J, HOFFMANN D, NAIK R and SEDLACEK H: ANTITUMORAL ACTIVITY OF FLAVONE L-86-8275. Int J Oncol 6: 31-36, 1995.
APA
CZECH, J., HOFFMANN, D., NAIK, R., & SEDLACEK, H. (1995). ANTITUMORAL ACTIVITY OF FLAVONE L-86-8275. International Journal of Oncology, 6, 31-36. https://doi.org/10.3892/ijo.6.1.31
MLA
CZECH, J., HOFFMANN, D., NAIK, R., SEDLACEK, H."ANTITUMORAL ACTIVITY OF FLAVONE L-86-8275". International Journal of Oncology 6.1 (1995): 31-36.
Chicago
CZECH, J., HOFFMANN, D., NAIK, R., SEDLACEK, H."ANTITUMORAL ACTIVITY OF FLAVONE L-86-8275". International Journal of Oncology 6, no. 1 (1995): 31-36. https://doi.org/10.3892/ijo.6.1.31