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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 1995 Volume 6 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 1995 Volume 6 Issue 2

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Article

CLINICAL MODULATION OF EPIRUBICIN RESISTANCE BY LONIDAMINE IN PATIENTS WITH ADVANCED SOFT-TISSUE SARCOMAS

  • Authors:
    • M LOPEZ
    • S CARPANO
    • L DILAURO
    • L CHIATTI
    • P VICI
    • F CAVALIERE
    • P GENTILE
    • G CITRO

  • View Affiliations / Copyright

    Affiliations: Affliations not specified
  • Pages: 363-367
    |
    Published online on: February 1, 1995
       https://doi.org/10.3892/ijo.6.2.363
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Abstract

To determine if lonidamine (LND) could reverse anthracycline resistance In patients with advanced, soft-tissue sarcomas, thirty-six patients were treated with epirubicin (EPI) 120 mg/m(2) i.v. every 3 weeks. Progressive patients were given the same chemotherapy regimen on day 4 in combination with oral LND, 150 mg on day 1, 300 mg on day 2, and 450 mg on days 3 to 5. Among 35 evaluable patients there were 2 complete responses and 3 partial responses (PR) for an overall response rate of 14%. In the group treated with EPI+LND (24 evaluable patients) 2 PR were observed, lasting 3 and 10 months respectively. The overall survivall was 11.5 months. The most common side-effects were myelotoxicity, nausea and vomiting. Clinical cardiotoxicity was. not observed. Only in one patient a >20% decrease in LVEF from baseline was recorded. LND related toxicities were mild to moderate myalgia and photophobia. In a pharmacokinetic study performed parallel to the clinical study, no difference was observed between the parameters derived from EPI and EPI+LND curves except for Vapp. This study indicates that LND may circumvent clinical resistance in some cases without altering chemotherapy related toxicity.

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Copy and paste a formatted citation
Spandidos Publications style
LOPEZ M, CARPANO S, DILAURO L, CHIATTI L, VICI P, CAVALIERE F, GENTILE P and CITRO G: CLINICAL MODULATION OF EPIRUBICIN RESISTANCE BY LONIDAMINE IN PATIENTS WITH ADVANCED SOFT-TISSUE SARCOMAS. Int J Oncol 6: 363-367, 1995.
APA
LOPEZ, M., CARPANO, S., DILAURO, L., CHIATTI, L., VICI, P., CAVALIERE, F. ... CITRO, G. (1995). CLINICAL MODULATION OF EPIRUBICIN RESISTANCE BY LONIDAMINE IN PATIENTS WITH ADVANCED SOFT-TISSUE SARCOMAS. International Journal of Oncology, 6, 363-367. https://doi.org/10.3892/ijo.6.2.363
MLA
LOPEZ, M., CARPANO, S., DILAURO, L., CHIATTI, L., VICI, P., CAVALIERE, F., GENTILE, P., CITRO, G."CLINICAL MODULATION OF EPIRUBICIN RESISTANCE BY LONIDAMINE IN PATIENTS WITH ADVANCED SOFT-TISSUE SARCOMAS". International Journal of Oncology 6.2 (1995): 363-367.
Chicago
LOPEZ, M., CARPANO, S., DILAURO, L., CHIATTI, L., VICI, P., CAVALIERE, F., GENTILE, P., CITRO, G."CLINICAL MODULATION OF EPIRUBICIN RESISTANCE BY LONIDAMINE IN PATIENTS WITH ADVANCED SOFT-TISSUE SARCOMAS". International Journal of Oncology 6, no. 2 (1995): 363-367. https://doi.org/10.3892/ijo.6.2.363
Copy and paste a formatted citation
x
Spandidos Publications style
LOPEZ M, CARPANO S, DILAURO L, CHIATTI L, VICI P, CAVALIERE F, GENTILE P and CITRO G: CLINICAL MODULATION OF EPIRUBICIN RESISTANCE BY LONIDAMINE IN PATIENTS WITH ADVANCED SOFT-TISSUE SARCOMAS. Int J Oncol 6: 363-367, 1995.
APA
LOPEZ, M., CARPANO, S., DILAURO, L., CHIATTI, L., VICI, P., CAVALIERE, F. ... CITRO, G. (1995). CLINICAL MODULATION OF EPIRUBICIN RESISTANCE BY LONIDAMINE IN PATIENTS WITH ADVANCED SOFT-TISSUE SARCOMAS. International Journal of Oncology, 6, 363-367. https://doi.org/10.3892/ijo.6.2.363
MLA
LOPEZ, M., CARPANO, S., DILAURO, L., CHIATTI, L., VICI, P., CAVALIERE, F., GENTILE, P., CITRO, G."CLINICAL MODULATION OF EPIRUBICIN RESISTANCE BY LONIDAMINE IN PATIENTS WITH ADVANCED SOFT-TISSUE SARCOMAS". International Journal of Oncology 6.2 (1995): 363-367.
Chicago
LOPEZ, M., CARPANO, S., DILAURO, L., CHIATTI, L., VICI, P., CAVALIERE, F., GENTILE, P., CITRO, G."CLINICAL MODULATION OF EPIRUBICIN RESISTANCE BY LONIDAMINE IN PATIENTS WITH ADVANCED SOFT-TISSUE SARCOMAS". International Journal of Oncology 6, no. 2 (1995): 363-367. https://doi.org/10.3892/ijo.6.2.363
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