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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 1995 Volume 6 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 1995 Volume 6 Issue 3

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Article

EFFECTIVE IMMUNE REJECTION OF ADVANCED METASTASIZED CANCER

  • Authors:
    • V SCHIRRMACHER
    • P BECKHOVE
    • A KRUGER
    • M ROCHA
    • V UMANSKY
    • KP FICHTNER
    • WE HULL
    • U ZANGEMEISTERWITTKE
    • A GRIESBACH
    • K JURIANZ
    • P VONHOEGEN

  • View Affiliations / Copyright

    Affiliations: DEUTSCH KREBSFORSCHUNGSZENTRUM,ZENT SPEKT,HEIDELBERG,GERMANY.
  • Pages: 505-521
    |
    Published online on: March 1, 1995
       https://doi.org/10.3892/ijo.6.3.505
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Abstract

A cellular cancer therapy is described with unique efficiency even in late-stage disease. in situ activated tumor-immune T cells, induced in allogeneic, tumor-resistant, MHC identical but superantigen different donor mice (B10.D2) could transfer strong graft-versus-leukemia (GvL) effects accompanied by only mild graft-versus-host (GvH) reactivity. Systemic immune cell transfer into 5 Gy irradiated DBA/2 mice bearing up to 4 week established syngeneic tumors and macrometastases led to massive infiltration of tumor tissues by CD4 and CD8 donor T lymphocytes. Upon interaction of immune CD4 donor T cells with host antigen presenting cells in synergy with immune CD8 donor T cells attacking the tumor cells directly, primary tumors (1.5 cm diameter) were encapsulated and rejected from the skin and liver metastases eradicated. For the first time, such adoptive cellular immunotherapy (ADI) was followed in individual live animals by P-31-NMR spectroscopy of primary tumors. An approximately 25,000 fold excess of metastatic tumor cells could be rejected as revealed quantitatively by FACScan analysis of lacZ gene transfected tumor cells.

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Copy and paste a formatted citation
Spandidos Publications style
SCHIRRMACHER V, BECKHOVE P, KRUGER A, ROCHA M, UMANSKY V, FICHTNER K, HULL W, ZANGEMEISTERWITTKE U, GRIESBACH A, JURIANZ K, JURIANZ K, et al: EFFECTIVE IMMUNE REJECTION OF ADVANCED METASTASIZED CANCER. Int J Oncol 6: 505-521, 1995.
APA
SCHIRRMACHER, V., BECKHOVE, P., KRUGER, A., ROCHA, M., UMANSKY, V., FICHTNER, K. ... VONHOEGEN, P. (1995). EFFECTIVE IMMUNE REJECTION OF ADVANCED METASTASIZED CANCER. International Journal of Oncology, 6, 505-521. https://doi.org/10.3892/ijo.6.3.505
MLA
SCHIRRMACHER, V., BECKHOVE, P., KRUGER, A., ROCHA, M., UMANSKY, V., FICHTNER, K., HULL, W., ZANGEMEISTERWITTKE, U., GRIESBACH, A., JURIANZ, K., VONHOEGEN, P."EFFECTIVE IMMUNE REJECTION OF ADVANCED METASTASIZED CANCER". International Journal of Oncology 6.3 (1995): 505-521.
Chicago
SCHIRRMACHER, V., BECKHOVE, P., KRUGER, A., ROCHA, M., UMANSKY, V., FICHTNER, K., HULL, W., ZANGEMEISTERWITTKE, U., GRIESBACH, A., JURIANZ, K., VONHOEGEN, P."EFFECTIVE IMMUNE REJECTION OF ADVANCED METASTASIZED CANCER". International Journal of Oncology 6, no. 3 (1995): 505-521. https://doi.org/10.3892/ijo.6.3.505
Copy and paste a formatted citation
x
Spandidos Publications style
SCHIRRMACHER V, BECKHOVE P, KRUGER A, ROCHA M, UMANSKY V, FICHTNER K, HULL W, ZANGEMEISTERWITTKE U, GRIESBACH A, JURIANZ K, JURIANZ K, et al: EFFECTIVE IMMUNE REJECTION OF ADVANCED METASTASIZED CANCER. Int J Oncol 6: 505-521, 1995.
APA
SCHIRRMACHER, V., BECKHOVE, P., KRUGER, A., ROCHA, M., UMANSKY, V., FICHTNER, K. ... VONHOEGEN, P. (1995). EFFECTIVE IMMUNE REJECTION OF ADVANCED METASTASIZED CANCER. International Journal of Oncology, 6, 505-521. https://doi.org/10.3892/ijo.6.3.505
MLA
SCHIRRMACHER, V., BECKHOVE, P., KRUGER, A., ROCHA, M., UMANSKY, V., FICHTNER, K., HULL, W., ZANGEMEISTERWITTKE, U., GRIESBACH, A., JURIANZ, K., VONHOEGEN, P."EFFECTIVE IMMUNE REJECTION OF ADVANCED METASTASIZED CANCER". International Journal of Oncology 6.3 (1995): 505-521.
Chicago
SCHIRRMACHER, V., BECKHOVE, P., KRUGER, A., ROCHA, M., UMANSKY, V., FICHTNER, K., HULL, W., ZANGEMEISTERWITTKE, U., GRIESBACH, A., JURIANZ, K., VONHOEGEN, P."EFFECTIVE IMMUNE REJECTION OF ADVANCED METASTASIZED CANCER". International Journal of Oncology 6, no. 3 (1995): 505-521. https://doi.org/10.3892/ijo.6.3.505
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