DIPYRIDAMOLE AS A MODULATOR OF MULTIDRUG-RESISTANCE IN TUMOR-CELLS IN-VITRO

  • Authors:
    • E RAGAZZI
    • E BERTI
    • R CHIODO
    • S DANCONA
    • T BERTI
  • View Affiliations

  • Published online on: March 1, 1995     https://doi.org/10.3892/ijo.6.3.659
  • Pages: 659-662
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Abstract

The aim of the present study was to investigate in vitro the effect on LoVo cells (LoVo-S, doxorubicin-sensitive, and LoVo-R, doxorubicin-resistant) on the association of dipyridamole and certain antiblastic drugs (doxorubicin, idarubicin, mitoxantrone, teniposide) with different mechanisms of action. The cells were treated for 48 hours with the drugs, or were left for 24 hours without treatment (recovery period). The results demonstrate that dipyridamole possesses an inhibitory effect on cell growth, and that it potentiates the cytotoxic effect of the tested antiblastic drugs, particularly on LoVo-R cells. In the recovery period the inhibitory effect of dipyridamole on LoVo-S and LoVo-R cells was reversible, while the effect of the antitumour drugs, either alone or in association with dipyridamole, persisted. We suggest that dipyridamole has a synergistic effect on LoVo cell growth when associated with antiblastics; the increased effect produced on LoVo-R cells is indicative for a reversion of multidrug resistance, probably via a mechanism related to transmembrane transport system.

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March 1995
Volume 6 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
RAGAZZI E, BERTI E, CHIODO R, DANCONA S and BERTI T: DIPYRIDAMOLE AS A MODULATOR OF MULTIDRUG-RESISTANCE IN TUMOR-CELLS IN-VITRO. Int J Oncol 6: 659-662, 1995
APA
RAGAZZI, E., BERTI, E., CHIODO, R., DANCONA, S., & BERTI, T. (1995). DIPYRIDAMOLE AS A MODULATOR OF MULTIDRUG-RESISTANCE IN TUMOR-CELLS IN-VITRO. International Journal of Oncology, 6, 659-662. https://doi.org/10.3892/ijo.6.3.659
MLA
RAGAZZI, E., BERTI, E., CHIODO, R., DANCONA, S., BERTI, T."DIPYRIDAMOLE AS A MODULATOR OF MULTIDRUG-RESISTANCE IN TUMOR-CELLS IN-VITRO". International Journal of Oncology 6.3 (1995): 659-662.
Chicago
RAGAZZI, E., BERTI, E., CHIODO, R., DANCONA, S., BERTI, T."DIPYRIDAMOLE AS A MODULATOR OF MULTIDRUG-RESISTANCE IN TUMOR-CELLS IN-VITRO". International Journal of Oncology 6, no. 3 (1995): 659-662. https://doi.org/10.3892/ijo.6.3.659