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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 1995 Volume 6 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 1995 Volume 6 Issue 3

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Article

LINKAGE ANALYSES OF 3 FRENCH FAMILIES TO LOCI ON CHROMOSOME-2P AND CHROMOSOME-3P PREDISPOSING TO HEREDITARY NONPOLYPOSIS COLON-CANCER

  • Authors:
    • D BERNARD-GALLON
    • C RALLIERE
    • L ESSIOUX
    • S GOSSE
    • H CURE
    • JO BAY
    • S SCHRAUB
    • C BONAITI-PELLIE
    • H SOBOL
    • YJ BIGNON
  • View Affiliations / Copyright

    Affiliations: CTR JEAN PERRIN,UNITE PREVENT & DEPISTAGE CANC,ONCOL MOLEC LAB,F-63011 CLERMONT FERRAND,FRANCE. INSERM,U155,F-75016 PARIS,FRANCE. HOP JEAN MINJOZ,F-25030 BESANCON,FRANCE. INST J PAOLI I CALMETTES,F-13273 MARSEILLE 9,FRANCE. CTR LEON BERARD,UNITE ONCOL GENET,F-69373 LYON,FRANCE. LAB IMMUNOL,F-63170 CLERMONT FERRAND,FRANCE.
  • Pages: 699-703
    |
    Published online on: March 1, 1995
       https://doi.org/10.3892/ijo.6.3.699
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Abstract

Hereditary, non-polyposis colon cancer (HNPCC) is caused by mutations in different loci. One gene causing HNPCC was mapped to chromosome 2p and recently a tight linkage between a polymorphic marker on the chromosome 3p and the disease locus has been demonstrated and these families also manifest signs of a general DNA replicator disorder. We report detailed genetic studies of three French HNPCC families with D2S123 and D3S1029. In one of the families (F 230), the segregation pattern for markers on chromosomes 2 and 3 suggests absence of linkage. The two other families are not informative enough to conclude on linkage status with chromosomes 2 and 3. If confirmed, this result would mean that the inherited colon cancer in this family is linked to another HNPCC gene. Implication for genetic counselling is discussed. Even with cloned genes, linkage analysis with flanking microsatellite markers for informative families may help to avoid tedious work of seeking point mutations in HNPCC genes.

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Copy and paste a formatted citation
Spandidos Publications style
BERNARD-GALLON D, RALLIERE C, ESSIOUX L, GOSSE S, CURE H, BAY J, SCHRAUB S, BONAITI-PELLIE C, SOBOL H, BIGNON Y, BIGNON Y, et al: LINKAGE ANALYSES OF 3 FRENCH FAMILIES TO LOCI ON CHROMOSOME-2P AND CHROMOSOME-3P PREDISPOSING TO HEREDITARY NONPOLYPOSIS COLON-CANCER. Int J Oncol 6: 699-703, 1995.
APA
BERNARD-GALLON, D., RALLIERE, C., ESSIOUX, L., GOSSE, S., CURE, H., BAY, J. ... BIGNON, Y. (1995). LINKAGE ANALYSES OF 3 FRENCH FAMILIES TO LOCI ON CHROMOSOME-2P AND CHROMOSOME-3P PREDISPOSING TO HEREDITARY NONPOLYPOSIS COLON-CANCER. International Journal of Oncology, 6, 699-703. https://doi.org/10.3892/ijo.6.3.699
MLA
BERNARD-GALLON, D., RALLIERE, C., ESSIOUX, L., GOSSE, S., CURE, H., BAY, J., SCHRAUB, S., BONAITI-PELLIE, C., SOBOL, H., BIGNON, Y."LINKAGE ANALYSES OF 3 FRENCH FAMILIES TO LOCI ON CHROMOSOME-2P AND CHROMOSOME-3P PREDISPOSING TO HEREDITARY NONPOLYPOSIS COLON-CANCER". International Journal of Oncology 6.3 (1995): 699-703.
Chicago
BERNARD-GALLON, D., RALLIERE, C., ESSIOUX, L., GOSSE, S., CURE, H., BAY, J., SCHRAUB, S., BONAITI-PELLIE, C., SOBOL, H., BIGNON, Y."LINKAGE ANALYSES OF 3 FRENCH FAMILIES TO LOCI ON CHROMOSOME-2P AND CHROMOSOME-3P PREDISPOSING TO HEREDITARY NONPOLYPOSIS COLON-CANCER". International Journal of Oncology 6, no. 3 (1995): 699-703. https://doi.org/10.3892/ijo.6.3.699
Copy and paste a formatted citation
x
Spandidos Publications style
BERNARD-GALLON D, RALLIERE C, ESSIOUX L, GOSSE S, CURE H, BAY J, SCHRAUB S, BONAITI-PELLIE C, SOBOL H, BIGNON Y, BIGNON Y, et al: LINKAGE ANALYSES OF 3 FRENCH FAMILIES TO LOCI ON CHROMOSOME-2P AND CHROMOSOME-3P PREDISPOSING TO HEREDITARY NONPOLYPOSIS COLON-CANCER. Int J Oncol 6: 699-703, 1995.
APA
BERNARD-GALLON, D., RALLIERE, C., ESSIOUX, L., GOSSE, S., CURE, H., BAY, J. ... BIGNON, Y. (1995). LINKAGE ANALYSES OF 3 FRENCH FAMILIES TO LOCI ON CHROMOSOME-2P AND CHROMOSOME-3P PREDISPOSING TO HEREDITARY NONPOLYPOSIS COLON-CANCER. International Journal of Oncology, 6, 699-703. https://doi.org/10.3892/ijo.6.3.699
MLA
BERNARD-GALLON, D., RALLIERE, C., ESSIOUX, L., GOSSE, S., CURE, H., BAY, J., SCHRAUB, S., BONAITI-PELLIE, C., SOBOL, H., BIGNON, Y."LINKAGE ANALYSES OF 3 FRENCH FAMILIES TO LOCI ON CHROMOSOME-2P AND CHROMOSOME-3P PREDISPOSING TO HEREDITARY NONPOLYPOSIS COLON-CANCER". International Journal of Oncology 6.3 (1995): 699-703.
Chicago
BERNARD-GALLON, D., RALLIERE, C., ESSIOUX, L., GOSSE, S., CURE, H., BAY, J., SCHRAUB, S., BONAITI-PELLIE, C., SOBOL, H., BIGNON, Y."LINKAGE ANALYSES OF 3 FRENCH FAMILIES TO LOCI ON CHROMOSOME-2P AND CHROMOSOME-3P PREDISPOSING TO HEREDITARY NONPOLYPOSIS COLON-CANCER". International Journal of Oncology 6, no. 3 (1995): 699-703. https://doi.org/10.3892/ijo.6.3.699
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