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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 1995 Volume 6 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 1995 Volume 6 Issue 3

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Article

ANALYSIS OF C-MYC MESSENGER-RNA EXPRESSION IN PRIMARY BREAST CARCINOMAS WITH CLINICAL FOLLOW-UP

  • Authors:
    • CTF OSHIMA
    • MA NAGAI
    • LA MARQUES
    • MM BRENTANI

  • View Affiliations / Copyright

    Affiliations: UNIV SAO PAULO,FAC MED,DEPT RADIOL,DISCIPLINA ONCOL,BR-01246000 SAO PAULO,BRAZIL. FUNDACAO ONCOCENTRO SAO PAULO,SAO PAULO,BRAZIL. HOSP AC CARMARGO FUNDACAO ANTONIO PRUDENTE,SAO PAULO,BRAZIL.
  • Pages: 719-723
    |
    Published online on: March 1, 1995
       https://doi.org/10.3892/ijo.6.3.719
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Abstract

The level of c-myc messenger RNA was measured in 105 primary breast carcinoma samples and matched normal breast tissue from the same patients. Only tumors showing a greater than 2-fold increase in c-myc levels were considered to be overexpressed. Overexpression of c-myc mRNA was identified in 27.6% of tumor samples analysed and was significantly correlated with mitotic grade (p=0.05) and intense lymphocytic infiltrate (p=0.026) but not with other clinical and pathological variables such as size, necrosis, lymph node involvement, estrogen or progesterone receptor status, menopausal status, age or staging of the patients and increased risk of relapse or overall survival. Approximately 25% of the tumors contained overexpression of c-erbB-2 mRNA and simultaneous overexpression of the two oncogenes was seen in only five samples. Disease-free survival was significantly shorter in these patients (p=0.02) and this reduction remained significant after adjustment for nodal status. However, simultaneous overexpression of c-myc and c-erbB-2 did not improve significantly the prediction of risk of death.

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Copy and paste a formatted citation
Spandidos Publications style
OSHIMA C, NAGAI M, MARQUES L and BRENTANI M: ANALYSIS OF C-MYC MESSENGER-RNA EXPRESSION IN PRIMARY BREAST CARCINOMAS WITH CLINICAL FOLLOW-UP. Int J Oncol 6: 719-723, 1995.
APA
OSHIMA, C., NAGAI, M., MARQUES, L., & BRENTANI, M. (1995). ANALYSIS OF C-MYC MESSENGER-RNA EXPRESSION IN PRIMARY BREAST CARCINOMAS WITH CLINICAL FOLLOW-UP. International Journal of Oncology, 6, 719-723. https://doi.org/10.3892/ijo.6.3.719
MLA
OSHIMA, C., NAGAI, M., MARQUES, L., BRENTANI, M."ANALYSIS OF C-MYC MESSENGER-RNA EXPRESSION IN PRIMARY BREAST CARCINOMAS WITH CLINICAL FOLLOW-UP". International Journal of Oncology 6.3 (1995): 719-723.
Chicago
OSHIMA, C., NAGAI, M., MARQUES, L., BRENTANI, M."ANALYSIS OF C-MYC MESSENGER-RNA EXPRESSION IN PRIMARY BREAST CARCINOMAS WITH CLINICAL FOLLOW-UP". International Journal of Oncology 6, no. 3 (1995): 719-723. https://doi.org/10.3892/ijo.6.3.719
Copy and paste a formatted citation
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Spandidos Publications style
OSHIMA C, NAGAI M, MARQUES L and BRENTANI M: ANALYSIS OF C-MYC MESSENGER-RNA EXPRESSION IN PRIMARY BREAST CARCINOMAS WITH CLINICAL FOLLOW-UP. Int J Oncol 6: 719-723, 1995.
APA
OSHIMA, C., NAGAI, M., MARQUES, L., & BRENTANI, M. (1995). ANALYSIS OF C-MYC MESSENGER-RNA EXPRESSION IN PRIMARY BREAST CARCINOMAS WITH CLINICAL FOLLOW-UP. International Journal of Oncology, 6, 719-723. https://doi.org/10.3892/ijo.6.3.719
MLA
OSHIMA, C., NAGAI, M., MARQUES, L., BRENTANI, M."ANALYSIS OF C-MYC MESSENGER-RNA EXPRESSION IN PRIMARY BREAST CARCINOMAS WITH CLINICAL FOLLOW-UP". International Journal of Oncology 6.3 (1995): 719-723.
Chicago
OSHIMA, C., NAGAI, M., MARQUES, L., BRENTANI, M."ANALYSIS OF C-MYC MESSENGER-RNA EXPRESSION IN PRIMARY BREAST CARCINOMAS WITH CLINICAL FOLLOW-UP". International Journal of Oncology 6, no. 3 (1995): 719-723. https://doi.org/10.3892/ijo.6.3.719
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