INFLUENCE OF RETROVIRALLY TRANSDUCED HUMAN TUMOR-NECROSIS-FACTOR-ALPHA ON THE EXPRESSION OF C-MYC, K-RAS, C-JUN, P53, TGF-ALPHA, AND CEA IN HUMAN COLON-CARCINOMA CELL-LINES
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- Published online on: May 1, 1995 https://doi.org/10.3892/ijo.6.5.1027
- Pages: 1027-1031
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Abstract
Northern slot blot hybridization and immunohistochemical staining were applied for the characterization of tumor necrosis factor alpha (TNF)-transduced human colon carcinoma cell lines. A significant decrease in the CEA-specific mRNA and protein was observed in TNF-transduced tumor cells LS174T and LoVo while other probes (c-myc, K-ras, c-jun, p53, TGF alpha) as well as anti-K-ras- and anti-p53-antibodies failed to detect differences between cytokine-transduced and parental tumor cells.