ESTABLISHMENT OF A NEW HUMAN UTERINE CERVICAL ADENOCARCINOMA CELL-LINE, SISO, AND ITS REACTIVITY TO ANTICANCER REAGENTS
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- Published online on: May 1, 1995 https://doi.org/10.3892/ijo.6.5.1099
- Pages: 1099-1104
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Abstract
A human cell line, SiSo, was established from a patient afflicted with uterine cervical adenocarcinoma. The SiSo cell expresses MHC class I antigen, various kinds of adhesion molecules and tumor-associated antigens such as CA125, CEA and GA733. The secretion of CA125 antigen was markedly suppressed by anti-cancer reagents. However, their growth was not affected by any of the anti-cancer reagents tested, suggesting a discrepancy between inhibition of tumor growth and suppression of secretion of tumor-associated antigens after treatment with anti-cancer reagents. The SiSo cell line will provide a tool for investigation of uterine adenocarcinoma.
