EFFECTS OF ANTISENSE OLIGONUCLEOTIDES TARGETING K-RAS EXPRESSION IN PANCREATIC-CANCER CELL-LINES

  • Authors:
    • G CARTER
    • C GILBERT
    • NR LEMOINE
  • View Affiliations

  • Published online on: May 1, 1995     https://doi.org/10.3892/ijo.6.5.1105
  • Pages: 1105-1112
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Abstract

The K-ras oncogene is activated in more than 75% of pancreatic cancers and represents a compelling target for therapeutic intervention. We have examined the potential of K-ras antisense oligonucleotides in human pancreatic cancer cell lines. Dose-dependent antiproliferative effects are seen, but these do not correlate with reduced K-ras levels in the treated cells. Although patterns of uptake can be altered by treatment with cationic lipids, this does not enhance antiproliferative effects nor reduce K-ras expression. The antisense approach requires considerable development before useful anti-cancer agents can emerge and alternative approaches are needed for K-ras to be a target for genetic intervention therapy for human cancer.

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May 1995
Volume 6 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
CARTER G, GILBERT C and LEMOINE N: EFFECTS OF ANTISENSE OLIGONUCLEOTIDES TARGETING K-RAS EXPRESSION IN PANCREATIC-CANCER CELL-LINES. Int J Oncol 6: 1105-1112, 1995
APA
CARTER, G., GILBERT, C., & LEMOINE, N. (1995). EFFECTS OF ANTISENSE OLIGONUCLEOTIDES TARGETING K-RAS EXPRESSION IN PANCREATIC-CANCER CELL-LINES. International Journal of Oncology, 6, 1105-1112. https://doi.org/10.3892/ijo.6.5.1105
MLA
CARTER, G., GILBERT, C., LEMOINE, N."EFFECTS OF ANTISENSE OLIGONUCLEOTIDES TARGETING K-RAS EXPRESSION IN PANCREATIC-CANCER CELL-LINES". International Journal of Oncology 6.5 (1995): 1105-1112.
Chicago
CARTER, G., GILBERT, C., LEMOINE, N."EFFECTS OF ANTISENSE OLIGONUCLEOTIDES TARGETING K-RAS EXPRESSION IN PANCREATIC-CANCER CELL-LINES". International Journal of Oncology 6, no. 5 (1995): 1105-1112. https://doi.org/10.3892/ijo.6.5.1105