UP-REGULATION OF A TUMOR-ASSOCIATED ANTIGEN (TAG-72) BY INTERFERON-ALPHA AND INTERFERON-GAMMA IN PATIENTS WITH CUTANEOUS BREAST-CANCER RECURRENCES

  • Authors:
    • L OZZELLO
    • CM DEROSA
    • DV HABIF
    • K CANTELL
    • S PESTKA
  • View Affiliations

  • Published online on: May 1, 1995     https://doi.org/10.3892/ijo.6.5.985
  • Pages: 985-991
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Abstract

Up-regulation of a tumor-associated antigen (TAA) TAG-72 was investigated immunohistochemically in skin recurrences of 10 breast cancer patients treated with intralesional injections of natural interferons (nIFNs) alpha and gamma. Up-regulation was assessed by comparing the immunoreactivity of pre-IFN and post-IFN specimens stained with monoclonal antibodies (MoAbs) B72.3 and CC49 at near end-point dilutions. Varying degrees of enhanced immunoreactivity were detected in IFN-injected and non-IFN-injected lesions except in 1 patient with high constitutive expression of TAG-72 and another patient not expressing TAG-72. Thus, IFN-mediated up-regulation of TAG-72 can occur in patients whose breast cancer cells express this TAA, independently of the initial levels of antigenic expression.

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May 1995
Volume 6 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
OZZELLO L, DEROSA C, HABIF D, CANTELL K and PESTKA S: UP-REGULATION OF A TUMOR-ASSOCIATED ANTIGEN (TAG-72) BY INTERFERON-ALPHA AND INTERFERON-GAMMA IN PATIENTS WITH CUTANEOUS BREAST-CANCER RECURRENCES. Int J Oncol 6: 985-991, 1995.
APA
OZZELLO, L., DEROSA, C., HABIF, D., CANTELL, K., & PESTKA, S. (1995). UP-REGULATION OF A TUMOR-ASSOCIATED ANTIGEN (TAG-72) BY INTERFERON-ALPHA AND INTERFERON-GAMMA IN PATIENTS WITH CUTANEOUS BREAST-CANCER RECURRENCES. International Journal of Oncology, 6, 985-991. https://doi.org/10.3892/ijo.6.5.985
MLA
OZZELLO, L., DEROSA, C., HABIF, D., CANTELL, K., PESTKA, S."UP-REGULATION OF A TUMOR-ASSOCIATED ANTIGEN (TAG-72) BY INTERFERON-ALPHA AND INTERFERON-GAMMA IN PATIENTS WITH CUTANEOUS BREAST-CANCER RECURRENCES". International Journal of Oncology 6.5 (1995): 985-991.
Chicago
OZZELLO, L., DEROSA, C., HABIF, D., CANTELL, K., PESTKA, S."UP-REGULATION OF A TUMOR-ASSOCIATED ANTIGEN (TAG-72) BY INTERFERON-ALPHA AND INTERFERON-GAMMA IN PATIENTS WITH CUTANEOUS BREAST-CANCER RECURRENCES". International Journal of Oncology 6, no. 5 (1995): 985-991. https://doi.org/10.3892/ijo.6.5.985