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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 1995 Volume 7 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 1995 Volume 7 Issue 1

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Review

THE ANTIPROLIFERATIVE ASPECTS OF MORTALIN (REVIEW)

  • Authors:
    • R WADHWA
    • Y MITSUI
    • T IDE
    • SC KAUL

  • View Affiliations / Copyright

    Affiliations: NATL INST BIOSCI & HUMAN TECHNOL,AGCY IND SCI & TECHNOL,TSUKUBA,IBARAKI 305,JAPAN. HIROSHIMA UNIV,SCH MED,DEPT CELL & MOLEC BIOL,HIROSHIMA 734,JAPAN.
  • Pages: 69-74
    |
    Published online on: July 1, 1995
       https://doi.org/10.3892/ijo.7.1.69
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Abstract

Cellular mortal and immortal phenotypes as defined by the limited and the infinite capacity of cells to divide are the characteristics of normal and cancerous cells in culture. Numerous strategies that have been employed to understand the mechanism(s) of normal as well as tumor cell growth have revealed that these are genetically controlled, however, the genes and the synchronized regulations remain largely undefined so far. The present report reviews the identification of mortalin, a novel member of murine hsp70 family of proteins, as a gene involved in pathways that determine divisional phenotype of cells in vitro. In the present study, the anti-proliferative activity of mortalin is demonstrated also in human skin fibroblasts (TIG-73PD) by microinjection of anti-mortalin antibody. Furthermore, studies on the mortalin immunofluorescence patterns in SV40-immortalized pre-crisis and post-crisis human cells have revealed that the change in the intracellular distribution of mortalin is linked to the change in the divisional phenotype of cells. Thus, the studies to resolve the molecular basis of association of the cytosolically distributed form of mortalin with cellular mortal phenotype would be important in understanding of the mechanism(s) that determine replicative potential of cells in culture.

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Copy and paste a formatted citation
Spandidos Publications style
WADHWA R, MITSUI Y, IDE T and KAUL S: THE ANTIPROLIFERATIVE ASPECTS OF MORTALIN (REVIEW). Int J Oncol 7: 69-74, 1995.
APA
WADHWA, R., MITSUI, Y., IDE, T., & KAUL, S. (1995). THE ANTIPROLIFERATIVE ASPECTS OF MORTALIN (REVIEW). International Journal of Oncology, 7, 69-74. https://doi.org/10.3892/ijo.7.1.69
MLA
WADHWA, R., MITSUI, Y., IDE, T., KAUL, S."THE ANTIPROLIFERATIVE ASPECTS OF MORTALIN (REVIEW)". International Journal of Oncology 7.1 (1995): 69-74.
Chicago
WADHWA, R., MITSUI, Y., IDE, T., KAUL, S."THE ANTIPROLIFERATIVE ASPECTS OF MORTALIN (REVIEW)". International Journal of Oncology 7, no. 1 (1995): 69-74. https://doi.org/10.3892/ijo.7.1.69
Copy and paste a formatted citation
x
Spandidos Publications style
WADHWA R, MITSUI Y, IDE T and KAUL S: THE ANTIPROLIFERATIVE ASPECTS OF MORTALIN (REVIEW). Int J Oncol 7: 69-74, 1995.
APA
WADHWA, R., MITSUI, Y., IDE, T., & KAUL, S. (1995). THE ANTIPROLIFERATIVE ASPECTS OF MORTALIN (REVIEW). International Journal of Oncology, 7, 69-74. https://doi.org/10.3892/ijo.7.1.69
MLA
WADHWA, R., MITSUI, Y., IDE, T., KAUL, S."THE ANTIPROLIFERATIVE ASPECTS OF MORTALIN (REVIEW)". International Journal of Oncology 7.1 (1995): 69-74.
Chicago
WADHWA, R., MITSUI, Y., IDE, T., KAUL, S."THE ANTIPROLIFERATIVE ASPECTS OF MORTALIN (REVIEW)". International Journal of Oncology 7, no. 1 (1995): 69-74. https://doi.org/10.3892/ijo.7.1.69
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