POLYMORPHISM OF THE HPV-16 E6 GENE OF CERVICAL-CARCINOMA

  • Authors:
    • RA BURGER
    • LM ALVAREZ-SALAS
    • SP WILCZYNSKI
    • BJ MONK
    • JA DIPAOLO
  • View Affiliations

  • Published online on: August 1, 1995     https://doi.org/10.3892/ijo.7.2.261
  • Pages: 261-266
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Abstract

Polymorphism of the human papillomavirus type 16 (HPV-16) genome has been reported to occur within the noncoding regulatory long control region (LCR) and in the E7 and L1 genes. The current study focuses on the HPV-16 E6 oncogene which interacts with the antioncogenic regulator p53. Seventy-eight HPV-16-positive DNA samples derived from cervical carcinomas were screened for the presence of polymorphism in the HPV-16 E6 gene by polymerase chain reaction (PCR) linked single stranded conformational polymorphism (SSCP) analysis. Nine DNA samples had heterozygous mutations within the same region of the E6 gene 3' terminus; T to C transitions at HPV-16 position 511 (silent) and one of the nine also had a 513 mutation (Met to Thr). These mutations correlated with the clinical aggressiveness of the tumor, suggesting that the presence of these mutations may be due to genomic instability of advanced cervical carcinoma.

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August 1995
Volume 7 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
BURGER R, ALVAREZ-SALAS L, WILCZYNSKI S, MONK B and DIPAOLO J: POLYMORPHISM OF THE HPV-16 E6 GENE OF CERVICAL-CARCINOMA. Int J Oncol 7: 261-266, 1995
APA
BURGER, R., ALVAREZ-SALAS, L., WILCZYNSKI, S., MONK, B., & DIPAOLO, J. (1995). POLYMORPHISM OF THE HPV-16 E6 GENE OF CERVICAL-CARCINOMA. International Journal of Oncology, 7, 261-266. https://doi.org/10.3892/ijo.7.2.261
MLA
BURGER, R., ALVAREZ-SALAS, L., WILCZYNSKI, S., MONK, B., DIPAOLO, J."POLYMORPHISM OF THE HPV-16 E6 GENE OF CERVICAL-CARCINOMA". International Journal of Oncology 7.2 (1995): 261-266.
Chicago
BURGER, R., ALVAREZ-SALAS, L., WILCZYNSKI, S., MONK, B., DIPAOLO, J."POLYMORPHISM OF THE HPV-16 E6 GENE OF CERVICAL-CARCINOMA". International Journal of Oncology 7, no. 2 (1995): 261-266. https://doi.org/10.3892/ijo.7.2.261