INCREASED EXPRESSION OF GELATINASE-A AND TIMP-2 IN PRIMARY HUMAN GLIOBLASTOMAS

  • Authors:
    • A SAXENA
    • JT ROBERTSON
    • C KUFTA
    • WG STETLERSTEVENSON
    • IU ALI
  • View Affiliations

  • Published online on: September 1, 1995     https://doi.org/10.3892/ijo.7.3.469
  • Pages: 469-473
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Abstract

The highly invasive growth of glioblastomas may be a consequence of an abnormal profile of proteinases and proteinase inhibitors involved in remodeling of the basement membrane and normal vasculature. We have detected a 1.5-3-fold increase in the transcription of gelatinase A and TIMP-2 (Tissue Inhibitor of Metalloproteinase) in glioblastomas as compared to the normal brain tissue. Increased expression of gelatinase A and TIMP-2 in these tumors was also evident by immunohistochemical analysis. Our data suggest that increased expression and perturbation of the balance between metalloproteinases and their inhibitors that are involved in extracellular matrix remodeling and angiogenesis may contribute to the invasive phenotype of glioblastomas.

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September 1995
Volume 7 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
SAXENA A, ROBERTSON J, KUFTA C, STETLERSTEVENSON W and ALI I: INCREASED EXPRESSION OF GELATINASE-A AND TIMP-2 IN PRIMARY HUMAN GLIOBLASTOMAS. Int J Oncol 7: 469-473, 1995
APA
SAXENA, A., ROBERTSON, J., KUFTA, C., STETLERSTEVENSON, W., & ALI, I. (1995). INCREASED EXPRESSION OF GELATINASE-A AND TIMP-2 IN PRIMARY HUMAN GLIOBLASTOMAS. International Journal of Oncology, 7, 469-473. https://doi.org/10.3892/ijo.7.3.469
MLA
SAXENA, A., ROBERTSON, J., KUFTA, C., STETLERSTEVENSON, W., ALI, I."INCREASED EXPRESSION OF GELATINASE-A AND TIMP-2 IN PRIMARY HUMAN GLIOBLASTOMAS". International Journal of Oncology 7.3 (1995): 469-473.
Chicago
SAXENA, A., ROBERTSON, J., KUFTA, C., STETLERSTEVENSON, W., ALI, I."INCREASED EXPRESSION OF GELATINASE-A AND TIMP-2 IN PRIMARY HUMAN GLIOBLASTOMAS". International Journal of Oncology 7, no. 3 (1995): 469-473. https://doi.org/10.3892/ijo.7.3.469