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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 1995 Volume 7 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 1995 Volume 7 Issue 3

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Article

INCREASED EXPRESSION OF GELATINASE-A AND TIMP-2 IN PRIMARY HUMAN GLIOBLASTOMAS

  • Authors:
    • A SAXENA
    • JT ROBERTSON
    • C KUFTA
    • WG STETLERSTEVENSON
    • IU ALI

  • View Affiliations / Copyright

    Affiliations: NCI,EXPTL IMMUNOL BRANCH,BETHESDA,MD 20892. UNIV TENNESSEE,DEPT NEUROSURG,MEMPHIS,TN 38119. NINCDS,SURG NEUROL BRANCH,BALTIMORE,MD. NCI,PATHOL LAB,BETHESDA,MD 20892.
  • Pages: 469-473
    |
    Published online on: September 1, 1995
       https://doi.org/10.3892/ijo.7.3.469
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Abstract

The highly invasive growth of glioblastomas may be a consequence of an abnormal profile of proteinases and proteinase inhibitors involved in remodeling of the basement membrane and normal vasculature. We have detected a 1.5-3-fold increase in the transcription of gelatinase A and TIMP-2 (Tissue Inhibitor of Metalloproteinase) in glioblastomas as compared to the normal brain tissue. Increased expression of gelatinase A and TIMP-2 in these tumors was also evident by immunohistochemical analysis. Our data suggest that increased expression and perturbation of the balance between metalloproteinases and their inhibitors that are involved in extracellular matrix remodeling and angiogenesis may contribute to the invasive phenotype of glioblastomas.

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Copy and paste a formatted citation
Spandidos Publications style
SAXENA A, ROBERTSON J, KUFTA C, STETLERSTEVENSON W and ALI I: INCREASED EXPRESSION OF GELATINASE-A AND TIMP-2 IN PRIMARY HUMAN GLIOBLASTOMAS. Int J Oncol 7: 469-473, 1995.
APA
SAXENA, A., ROBERTSON, J., KUFTA, C., STETLERSTEVENSON, W., & ALI, I. (1995). INCREASED EXPRESSION OF GELATINASE-A AND TIMP-2 IN PRIMARY HUMAN GLIOBLASTOMAS. International Journal of Oncology, 7, 469-473. https://doi.org/10.3892/ijo.7.3.469
MLA
SAXENA, A., ROBERTSON, J., KUFTA, C., STETLERSTEVENSON, W., ALI, I."INCREASED EXPRESSION OF GELATINASE-A AND TIMP-2 IN PRIMARY HUMAN GLIOBLASTOMAS". International Journal of Oncology 7.3 (1995): 469-473.
Chicago
SAXENA, A., ROBERTSON, J., KUFTA, C., STETLERSTEVENSON, W., ALI, I."INCREASED EXPRESSION OF GELATINASE-A AND TIMP-2 IN PRIMARY HUMAN GLIOBLASTOMAS". International Journal of Oncology 7, no. 3 (1995): 469-473. https://doi.org/10.3892/ijo.7.3.469
Copy and paste a formatted citation
x
Spandidos Publications style
SAXENA A, ROBERTSON J, KUFTA C, STETLERSTEVENSON W and ALI I: INCREASED EXPRESSION OF GELATINASE-A AND TIMP-2 IN PRIMARY HUMAN GLIOBLASTOMAS. Int J Oncol 7: 469-473, 1995.
APA
SAXENA, A., ROBERTSON, J., KUFTA, C., STETLERSTEVENSON, W., & ALI, I. (1995). INCREASED EXPRESSION OF GELATINASE-A AND TIMP-2 IN PRIMARY HUMAN GLIOBLASTOMAS. International Journal of Oncology, 7, 469-473. https://doi.org/10.3892/ijo.7.3.469
MLA
SAXENA, A., ROBERTSON, J., KUFTA, C., STETLERSTEVENSON, W., ALI, I."INCREASED EXPRESSION OF GELATINASE-A AND TIMP-2 IN PRIMARY HUMAN GLIOBLASTOMAS". International Journal of Oncology 7.3 (1995): 469-473.
Chicago
SAXENA, A., ROBERTSON, J., KUFTA, C., STETLERSTEVENSON, W., ALI, I."INCREASED EXPRESSION OF GELATINASE-A AND TIMP-2 IN PRIMARY HUMAN GLIOBLASTOMAS". International Journal of Oncology 7, no. 3 (1995): 469-473. https://doi.org/10.3892/ijo.7.3.469
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