INHIBIN ACTIVIN SUBUNITS AND ACTIVIN RECEPTORS IN HUMAN BREAST CELL-LINES AND LACTATING RAT MAMMARY-GLANDS

  • Authors:
    • SY YING
    • Z ZHANG
    • G HUANG
    • FC HSIEH
  • View Affiliations

  • Published online on: September 1, 1995     https://doi.org/10.3892/ijo.7.3.481
  • Pages: 481-485
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Abstract

We have reported previously that a human breast cancer cell line, MCF-7, transcribes messenger RNAs coding inhibin/activin alpha-, beta A-, and beta B-subunits and activin receptor II as well as produces inhibin and/or activin proteins, using immunocytochemistry, in situ hybridization, and the reverse transcription-polymerase chain reaction (RT-PCR) analysis. In the present study, we report that four additional cell lines derived from human breast cancers, T47D, HS-578, ZR-75-1, and MDA-MB 321 express mRNAs for alpha- and beta-subunits of inhibin/activin and activin receptors as well as stain positive with antisera specific for inhibin alpha- and inhibin/activin beta-subunits, respectively. We have also localized immunocytochemically inhibin and activin-A in rat lactating mammary glands and found mRNAs for activin receptors I, II, and IIB as well as follistatin, a binding protein for activin, in lactating rat mammary glands by RT-PCR. These findings provide additional evidence that inhibin and activin may be involved in regulating the normal and abnormal cell growth of mammary glands.

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September 1995
Volume 7 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
YING S, ZHANG Z, HUANG G and HSIEH F: INHIBIN ACTIVIN SUBUNITS AND ACTIVIN RECEPTORS IN HUMAN BREAST CELL-LINES AND LACTATING RAT MAMMARY-GLANDS. Int J Oncol 7: 481-485, 1995
APA
YING, S., ZHANG, Z., HUANG, G., & HSIEH, F. (1995). INHIBIN ACTIVIN SUBUNITS AND ACTIVIN RECEPTORS IN HUMAN BREAST CELL-LINES AND LACTATING RAT MAMMARY-GLANDS. International Journal of Oncology, 7, 481-485. https://doi.org/10.3892/ijo.7.3.481
MLA
YING, S., ZHANG, Z., HUANG, G., HSIEH, F."INHIBIN ACTIVIN SUBUNITS AND ACTIVIN RECEPTORS IN HUMAN BREAST CELL-LINES AND LACTATING RAT MAMMARY-GLANDS". International Journal of Oncology 7.3 (1995): 481-485.
Chicago
YING, S., ZHANG, Z., HUANG, G., HSIEH, F."INHIBIN ACTIVIN SUBUNITS AND ACTIVIN RECEPTORS IN HUMAN BREAST CELL-LINES AND LACTATING RAT MAMMARY-GLANDS". International Journal of Oncology 7, no. 3 (1995): 481-485. https://doi.org/10.3892/ijo.7.3.481