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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 1995 Volume 7 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 1995 Volume 7 Issue 3

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Article

ADHESIVE FUNCTION OF NEWCASTLE-DISEASE VIRUS HEMAGGLUTININ IN TUMOR-HOST INTERACTION

  • Authors:
    • K JURIANZ
    • C HAAS
    • M HUBBE
    • C ERTEL
    • G BRUNNER
    • P ALTEVOGT
    • V SCHIRRMACHER
    • P VON HOEGEN

  • View Affiliations / Copyright

    Affiliations: SMITHKLINE BEECHAM BIOL SA,R&D IMMUNOL BIOL,B-1330 RIXENSART,BELGIUM. DEUTSCH KREBSFORSCHUNGSZENTRUM,DIV TUMOR IMMUNOL 0710,D-69120 HEIDELBERG,GERMANY.
  • Pages: 539-545
    |
    Published online on: September 1, 1995
       https://doi.org/10.3892/ijo.7.3.539
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Abstract

Infection of metastatic lymphoma cells (ESbL) by a low dose of a non-lytic strain of Newcastle disease virus (NDV) leads to viral replication followed by strong cell surface expression of viral antigens, especially hemagglutinin neuraminidase (HN). The expressed HN was functional and facilitated cell-cell interactions and cell attachment. This was shown for NDV infected tumor cells, lymphocytes, fibroblasts and endothelial cells. The interactions could be strongly inhibited by antibodies against the viral HN protein. Increased binding was also seen with HN c-DNA transfectants expressing the HN as the only viral protein. Viral infection did not influence proliferation and lysability of the infected tumor cells. Following intravenous injection of tumor cells, the number of hepatic metastases was significantly reduced when the cells had been pre-infected with NDV. This reduction of metastases correlated with an increased survival time of the animals. As potential mechanisms of these NDV effects we propose augmentation of cell-eel interactions and immune functions and reduction of invasive capacity of NDV infected, as compared to non-infected tumor cells.

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Copy and paste a formatted citation
Spandidos Publications style
JURIANZ K, HAAS C, HUBBE M, ERTEL C, BRUNNER G, ALTEVOGT P, SCHIRRMACHER V and VON HOEGEN P: ADHESIVE FUNCTION OF NEWCASTLE-DISEASE VIRUS HEMAGGLUTININ IN TUMOR-HOST INTERACTION. Int J Oncol 7: 539-545, 1995.
APA
JURIANZ, K., HAAS, C., HUBBE, M., ERTEL, C., BRUNNER, G., ALTEVOGT, P. ... VON HOEGEN, P. (1995). ADHESIVE FUNCTION OF NEWCASTLE-DISEASE VIRUS HEMAGGLUTININ IN TUMOR-HOST INTERACTION. International Journal of Oncology, 7, 539-545. https://doi.org/10.3892/ijo.7.3.539
MLA
JURIANZ, K., HAAS, C., HUBBE, M., ERTEL, C., BRUNNER, G., ALTEVOGT, P., SCHIRRMACHER, V., VON HOEGEN, P."ADHESIVE FUNCTION OF NEWCASTLE-DISEASE VIRUS HEMAGGLUTININ IN TUMOR-HOST INTERACTION". International Journal of Oncology 7.3 (1995): 539-545.
Chicago
JURIANZ, K., HAAS, C., HUBBE, M., ERTEL, C., BRUNNER, G., ALTEVOGT, P., SCHIRRMACHER, V., VON HOEGEN, P."ADHESIVE FUNCTION OF NEWCASTLE-DISEASE VIRUS HEMAGGLUTININ IN TUMOR-HOST INTERACTION". International Journal of Oncology 7, no. 3 (1995): 539-545. https://doi.org/10.3892/ijo.7.3.539
Copy and paste a formatted citation
x
Spandidos Publications style
JURIANZ K, HAAS C, HUBBE M, ERTEL C, BRUNNER G, ALTEVOGT P, SCHIRRMACHER V and VON HOEGEN P: ADHESIVE FUNCTION OF NEWCASTLE-DISEASE VIRUS HEMAGGLUTININ IN TUMOR-HOST INTERACTION. Int J Oncol 7: 539-545, 1995.
APA
JURIANZ, K., HAAS, C., HUBBE, M., ERTEL, C., BRUNNER, G., ALTEVOGT, P. ... VON HOEGEN, P. (1995). ADHESIVE FUNCTION OF NEWCASTLE-DISEASE VIRUS HEMAGGLUTININ IN TUMOR-HOST INTERACTION. International Journal of Oncology, 7, 539-545. https://doi.org/10.3892/ijo.7.3.539
MLA
JURIANZ, K., HAAS, C., HUBBE, M., ERTEL, C., BRUNNER, G., ALTEVOGT, P., SCHIRRMACHER, V., VON HOEGEN, P."ADHESIVE FUNCTION OF NEWCASTLE-DISEASE VIRUS HEMAGGLUTININ IN TUMOR-HOST INTERACTION". International Journal of Oncology 7.3 (1995): 539-545.
Chicago
JURIANZ, K., HAAS, C., HUBBE, M., ERTEL, C., BRUNNER, G., ALTEVOGT, P., SCHIRRMACHER, V., VON HOEGEN, P."ADHESIVE FUNCTION OF NEWCASTLE-DISEASE VIRUS HEMAGGLUTININ IN TUMOR-HOST INTERACTION". International Journal of Oncology 7, no. 3 (1995): 539-545. https://doi.org/10.3892/ijo.7.3.539
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