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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 1995 Volume 7 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 1995 Volume 7 Issue 3

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Article

ALTERATIONS OF THE APC GENE IN CARCINOMA CELL-LINES AND PRECANCEROUS LESIONS OF THE STOMACH

  • Authors:
    • K NISHIMURA
    • H YOKOZAKI
    • K HARUMA
    • G KAJIYAMA
    • E TAHARA

  • View Affiliations / Copyright

    Affiliations: HIROSHIMA UNIV,SCH MED,DEPT PATHOL 1,MINAMI KU,HIROSHIMA 734,JAPAN. HIROSHIMA UNIV,SCH MED,DEPT INTERNAL MED 1,MINAMI KU,HIROSHIMA 734,JAPAN.
  • Pages: 587-592
    |
    Published online on: September 1, 1995
       https://doi.org/10.3892/ijo.7.3.587
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Abstract

Somatic mutations of the APC gene in eight cancer cell lines, twelve adenomas and sixteen intestinal metaplasias of the stomach were examined. The expression of the APC mRNA and protein in eight cancer cell lines was also investigated. PCR-SSCP analysis detected mutations of the APC gene in 25% (2 out of 8) of cancer cell lines, 42% (5 out of 12) of gastric adenomas, 6% (1 out of 16) of intestinal metaplasia mucosae. Direct sequencing analysis confirmed nonsense mutations in one cancer cell line, one adenoma and one intestinal metaplasia mucosa resulted in truncation of the product, frameshift mutations in one adenoma and silent mutations in one cancer cell line and three adenomas. In addition, the KATO-III cell line, which was established from signet ring cell carcinoma, expressed very low level of APC mRNA and its APC protein could not be detected. On the other hand, the expression level of variant APC mRNA transcript which lacks exon 7 was relatively high in KATO-III. It is supposed that the variant APC mRNA transcript might contribute to the inactivation of the APC gene. These data overall provide strong evidence that changes in the APC gene play an important role in the early event of stomach carcinogenesis, especially in intestinal type gastric cancer.

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Copy and paste a formatted citation
Spandidos Publications style
NISHIMURA K, YOKOZAKI H, HARUMA K, KAJIYAMA G and TAHARA E: ALTERATIONS OF THE APC GENE IN CARCINOMA CELL-LINES AND PRECANCEROUS LESIONS OF THE STOMACH. Int J Oncol 7: 587-592, 1995.
APA
NISHIMURA, K., YOKOZAKI, H., HARUMA, K., KAJIYAMA, G., & TAHARA, E. (1995). ALTERATIONS OF THE APC GENE IN CARCINOMA CELL-LINES AND PRECANCEROUS LESIONS OF THE STOMACH. International Journal of Oncology, 7, 587-592. https://doi.org/10.3892/ijo.7.3.587
MLA
NISHIMURA, K., YOKOZAKI, H., HARUMA, K., KAJIYAMA, G., TAHARA, E."ALTERATIONS OF THE APC GENE IN CARCINOMA CELL-LINES AND PRECANCEROUS LESIONS OF THE STOMACH". International Journal of Oncology 7.3 (1995): 587-592.
Chicago
NISHIMURA, K., YOKOZAKI, H., HARUMA, K., KAJIYAMA, G., TAHARA, E."ALTERATIONS OF THE APC GENE IN CARCINOMA CELL-LINES AND PRECANCEROUS LESIONS OF THE STOMACH". International Journal of Oncology 7, no. 3 (1995): 587-592. https://doi.org/10.3892/ijo.7.3.587
Copy and paste a formatted citation
x
Spandidos Publications style
NISHIMURA K, YOKOZAKI H, HARUMA K, KAJIYAMA G and TAHARA E: ALTERATIONS OF THE APC GENE IN CARCINOMA CELL-LINES AND PRECANCEROUS LESIONS OF THE STOMACH. Int J Oncol 7: 587-592, 1995.
APA
NISHIMURA, K., YOKOZAKI, H., HARUMA, K., KAJIYAMA, G., & TAHARA, E. (1995). ALTERATIONS OF THE APC GENE IN CARCINOMA CELL-LINES AND PRECANCEROUS LESIONS OF THE STOMACH. International Journal of Oncology, 7, 587-592. https://doi.org/10.3892/ijo.7.3.587
MLA
NISHIMURA, K., YOKOZAKI, H., HARUMA, K., KAJIYAMA, G., TAHARA, E."ALTERATIONS OF THE APC GENE IN CARCINOMA CELL-LINES AND PRECANCEROUS LESIONS OF THE STOMACH". International Journal of Oncology 7.3 (1995): 587-592.
Chicago
NISHIMURA, K., YOKOZAKI, H., HARUMA, K., KAJIYAMA, G., TAHARA, E."ALTERATIONS OF THE APC GENE IN CARCINOMA CELL-LINES AND PRECANCEROUS LESIONS OF THE STOMACH". International Journal of Oncology 7, no. 3 (1995): 587-592. https://doi.org/10.3892/ijo.7.3.587
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