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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 1995 Volume 7 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 1995 Volume 7 Issue 3

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Article

ON THE USE OF SYRIAN-HAMSTER CELL-CULTURES AS TARGETS FOR CARCINOGEN-SCREENING

  • Authors:
    • PT IYPE
    • HL KUMARI
    • ME KAIGHN
    • B HUKKU

  • View Affiliations / Copyright

    Affiliations: WAYNE STATE UNIV,CHILDRENS HOSP MICHIGAN,SCH MED,DEPT PEDIAT,CELL CULTURE LAB,DETROIT,MI 48201.
  • Pages: 603-609
    |
    Published online on: September 1, 1995
       https://doi.org/10.3892/ijo.7.3.603
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Abstract

Syrian hamster embryo (SHE) cells have a reported culture lifespan limited to 30 to 40 population doublings (PDs). In contrast, we have observed continuous growth of two SHE cell lines without the hallmarks of cellular senescence. Two independent primary isolates (SHE-3, and SHE-15) have been grown for more than 160 PDs (SHE-3) and 50 PDs (SHE-15), respectively, with weekly subcultures and with no sign of senescence. During this study, we observed that SHE-3 cells ceased to multiply after about 30 PDs when grown in a nutritionally-inadequate serum-free medium, but resumed growth when switched to an adequate medium. The chromosomal profiles of both SHE cultures revealed a near diploid karyotype but not a completely normal karyotype, even at early passages with increasing chromosomal changes with continued culture. In addition, Syrian hamster chondrocytes were isolated, partially characterized, and their sensitivity to chemically-induced morphological transformation was compared to that of the standard Syrian hamster embryo (SHE) mixed cell culture. It appears that chondrocytes may be a suitable and more sensitive target for carcinogen-screening in vitro.

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Copy and paste a formatted citation
Spandidos Publications style
IYPE P, KUMARI H, KAIGHN M and HUKKU B: ON THE USE OF SYRIAN-HAMSTER CELL-CULTURES AS TARGETS FOR CARCINOGEN-SCREENING. Int J Oncol 7: 603-609, 1995.
APA
IYPE, P., KUMARI, H., KAIGHN, M., & HUKKU, B. (1995). ON THE USE OF SYRIAN-HAMSTER CELL-CULTURES AS TARGETS FOR CARCINOGEN-SCREENING. International Journal of Oncology, 7, 603-609. https://doi.org/10.3892/ijo.7.3.603
MLA
IYPE, P., KUMARI, H., KAIGHN, M., HUKKU, B."ON THE USE OF SYRIAN-HAMSTER CELL-CULTURES AS TARGETS FOR CARCINOGEN-SCREENING". International Journal of Oncology 7.3 (1995): 603-609.
Chicago
IYPE, P., KUMARI, H., KAIGHN, M., HUKKU, B."ON THE USE OF SYRIAN-HAMSTER CELL-CULTURES AS TARGETS FOR CARCINOGEN-SCREENING". International Journal of Oncology 7, no. 3 (1995): 603-609. https://doi.org/10.3892/ijo.7.3.603
Copy and paste a formatted citation
x
Spandidos Publications style
IYPE P, KUMARI H, KAIGHN M and HUKKU B: ON THE USE OF SYRIAN-HAMSTER CELL-CULTURES AS TARGETS FOR CARCINOGEN-SCREENING. Int J Oncol 7: 603-609, 1995.
APA
IYPE, P., KUMARI, H., KAIGHN, M., & HUKKU, B. (1995). ON THE USE OF SYRIAN-HAMSTER CELL-CULTURES AS TARGETS FOR CARCINOGEN-SCREENING. International Journal of Oncology, 7, 603-609. https://doi.org/10.3892/ijo.7.3.603
MLA
IYPE, P., KUMARI, H., KAIGHN, M., HUKKU, B."ON THE USE OF SYRIAN-HAMSTER CELL-CULTURES AS TARGETS FOR CARCINOGEN-SCREENING". International Journal of Oncology 7.3 (1995): 603-609.
Chicago
IYPE, P., KUMARI, H., KAIGHN, M., HUKKU, B."ON THE USE OF SYRIAN-HAMSTER CELL-CULTURES AS TARGETS FOR CARCINOGEN-SCREENING". International Journal of Oncology 7, no. 3 (1995): 603-609. https://doi.org/10.3892/ijo.7.3.603
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