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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 1995 Volume 7 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 1995 Volume 7 Issue 3

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Article

PROGNOSTIC-SIGNIFICANCE OF CHROMOSOME 5Q AND 17P ALLELIC DELETION IN COLORECTAL ADENOCARCINOMAS

  • Authors:
    • K KHINE
    • HS GOH
    • DR SMITH

  • View Affiliations / Copyright

    Affiliations: SINGAPORE GEN HOSP,DEPT COLORECTAL SURG,SINGAPORE 0315,SINGAPORE.
  • Pages: 631-635
    |
    Published online on: September 1, 1995
       https://doi.org/10.3892/ijo.7.3.631
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Abstract

Patient survival was analysed for 75 patients after surgery for primary colorectal adenocarcinoma with regards to allelic loss of chromosome 17p and chromosome 5q. Allelic loss of chromosome 17p occurred in 69% of patients and was not significantly associated with a poorer patient prognosis as assessed by log rank analysis of Kaplan-Meier survival plots (p = 0.161). Allelic loss of chromosome 5q occurred in 32% of patients and was significantly associated with a poorer patient prognosis as assessed by log rank analysis of Kaplan-Meier survival plots (p = 0.014). Analysis of the two variables by Cox regression analysis indicated that allelic loss of chromosome 5q was an independent variable for patient prognosis. Entry of Dukes' stage into the model resulted in a final model with Dukes' stage and allelic loss of chromosome 5q as independent significant variables in assessing patient survival. These results show that allelic loss of chromosome 5q, but not chromosome 17p provides additional prognostic information for assessing patient survival, over and above Dukes' stage.

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Copy and paste a formatted citation
Spandidos Publications style
KHINE K, GOH H and SMITH D: PROGNOSTIC-SIGNIFICANCE OF CHROMOSOME 5Q AND 17P ALLELIC DELETION IN COLORECTAL ADENOCARCINOMAS. Int J Oncol 7: 631-635, 1995.
APA
KHINE, K., GOH, H., & SMITH, D. (1995). PROGNOSTIC-SIGNIFICANCE OF CHROMOSOME 5Q AND 17P ALLELIC DELETION IN COLORECTAL ADENOCARCINOMAS. International Journal of Oncology, 7, 631-635. https://doi.org/10.3892/ijo.7.3.631
MLA
KHINE, K., GOH, H., SMITH, D."PROGNOSTIC-SIGNIFICANCE OF CHROMOSOME 5Q AND 17P ALLELIC DELETION IN COLORECTAL ADENOCARCINOMAS". International Journal of Oncology 7.3 (1995): 631-635.
Chicago
KHINE, K., GOH, H., SMITH, D."PROGNOSTIC-SIGNIFICANCE OF CHROMOSOME 5Q AND 17P ALLELIC DELETION IN COLORECTAL ADENOCARCINOMAS". International Journal of Oncology 7, no. 3 (1995): 631-635. https://doi.org/10.3892/ijo.7.3.631
Copy and paste a formatted citation
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Spandidos Publications style
KHINE K, GOH H and SMITH D: PROGNOSTIC-SIGNIFICANCE OF CHROMOSOME 5Q AND 17P ALLELIC DELETION IN COLORECTAL ADENOCARCINOMAS. Int J Oncol 7: 631-635, 1995.
APA
KHINE, K., GOH, H., & SMITH, D. (1995). PROGNOSTIC-SIGNIFICANCE OF CHROMOSOME 5Q AND 17P ALLELIC DELETION IN COLORECTAL ADENOCARCINOMAS. International Journal of Oncology, 7, 631-635. https://doi.org/10.3892/ijo.7.3.631
MLA
KHINE, K., GOH, H., SMITH, D."PROGNOSTIC-SIGNIFICANCE OF CHROMOSOME 5Q AND 17P ALLELIC DELETION IN COLORECTAL ADENOCARCINOMAS". International Journal of Oncology 7.3 (1995): 631-635.
Chicago
KHINE, K., GOH, H., SMITH, D."PROGNOSTIC-SIGNIFICANCE OF CHROMOSOME 5Q AND 17P ALLELIC DELETION IN COLORECTAL ADENOCARCINOMAS". International Journal of Oncology 7, no. 3 (1995): 631-635. https://doi.org/10.3892/ijo.7.3.631
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